Review
Behavioral Sciences
Zoe B. Taylor, Richard J. Stevenson, Lauren Ehrenfeld, Heather M. Francis
Summary: Research suggests that a Western-style diet has a negative impact on human hippocampal functioning, particularly affecting hippocampal volume and function, with no significant effects found for individual macronutrients. The high level of study heterogeneity suggests a need for further investigation into the underlying reasons.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Nutrition & Dietetics
Mrudhula Komanduri, Karen Savage, Ana Lea, Grace McPhee, Karen Nolidin, Saurenne Deleuil, Con Stough, Shakuntla Gondalia
Summary: This study examined the relationship between the gut microbiome and cognition. The results showed that specific bacterial families were associated with different cognitive domains, such as episodic secondary memory, working memory, and concentration.
Article
Nutrition & Dietetics
Sohvi Lommi, Muhammed Manzoor, Elina Engberg, Nitin Agrawal, Timo A. Lakka, Jukka Leinonen, Kaija-Leena Kolho, Heli Viljakainen
Summary: Excessive sugar consumption in youth is associated with poor health. However, evidence on the relationship between sugar consumption and the oral microbiome is limited. This study found that children who consume high levels of sugary treats have different compositions and metabolic pathways in their saliva microbiota compared to children with low levels of consumption.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Carina Carbia, Thomaz F. S. Bastiaanssen, Luigi Francesco Iannone, Ruben Garcia-Cabrerizo, Serena Boscaini, Kirsten Berding, Conall R. Strain, Gerard Clarke, Catherine Stanton, Timothy G. Dinan, John F. Cryan
Summary: This study investigated the effects of alcohol consumption on the gut microbiome and its association with social cognition, impulsivity, and craving. The results showed that binge drinking was associated with changes in the microbiome and difficulties in emotional recognition. Craving was strongly linked to alterations in the microbiome over time. These findings highlight the role of the gut microbiome as a regulator of social cognition and its relevance for addressing early alcohol-related issues during adolescence.
Article
Neurosciences
Sarah Nicolas, Ciaran S. O. Leime, Alan E. Hoban, Cara M. Hueston, John F. Cryan, Yvonne M. Nolan
Summary: Adolescent consumption of a cafeteria diet affects metabolic and inflammatory states in rats, but does not have lasting effects on behavior in adulthood.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Nutrition & Dietetics
Carlijn A. Wagenaar, Marieke van de Put, Michelle Bisschops, Wendy Walrabenstein, Catharina S. de Jonge, Hilde Herrema, Dirkjan van Schaardenburg
Summary: The study shows that high-fiber plant-based dietary interventions are more effective at reducing disease-specific outcomes and increasing microbiome diversity compared to other diets and fiber supplements, especially in patients with T2DM.
Review
Cell Biology
Sabrina Donati Zeppa, Deborah Agostini, Fabio Ferrini, Marco Gervasi, Elena Barbieri, Alessia Bartolacci, Giovanni Piccoli, Roberta Saltarelli, Piero Sestili, Vilberto Stocchi
Summary: In recent years, improvements in health and social conditions have resulted in increased average lifespan. Aging is the most significant risk factor for chronic diseases, making it crucial to develop therapies and interventions to improve the quality of life of the elderly by targeting age-related illnesses.
Article
Endocrinology & Metabolism
Pawel Karpinski, Paulina Zebrowska-Rozanska, Dorota Kujawa, Lukasz Laczmanski, Jerzy Samochowiec, Marcin Jablonski, Piotr Plichta, Patryk Piotrowski, Tomasz Bielawski, Blazej Misiak
Summary: This study aimed to compare gut microbiota between patients with schizophrenia and controls, taking into consideration factors such as exposure stress, dietary habits, metabolic parameters, and clinical manifestation. The results showed increased abundance of Lactobacillus and Limosilactobacillus and decreased abundance of Faecalibacterium and Paraprevotella in patients with schizophrenia. Machine learning analysis revealed that these gut microbiota differences were associated with factors such as psychosocial stress, poor nutrition, lipid profile alterations, and cognitive impairment.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luka Culig, Burcin Duan Sahbaz, Vilhelm A. Bohr
Summary: Ageing is a primary risk factor for neurodegenerative diseases. This review examines interventions that have the potential to extend lifespan in animals and how they might affect the brain to prevent or delay cognitive dysfunction and neurodegeneration.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Ecology
Hamza Anwer, Dominic Mason, Susanne Zajitschek, Daniel Hesselson, Daniel W. A. Noble, Margaret J. Morris, Malgorzata Lagisz, Shinichi Nakagawa
Summary: The obesity epidemic and its impact on cognition and behavior is a cause for concern. This study investigates the intergenerational effects of obesogenic diets on zebrafish cognition and anxiety. Results suggest that the negative effects of obesity on aversive learning can be carried across generations, with offspring from both obese parents performing poorly. However, offspring with only one obese parent performed the best. There were no significant differences in anxiety behaviors between groups. This study highlights the importance of investigating the effects of obesity on cognitive function and provides insights into intergenerational effects.
ECOLOGY AND EVOLUTION
(2022)
Article
Clinical Neurology
Vitor Breda, Raphael O. Cerqueira, Gilciane Ceolin, Elena Koning, Jennifer Fabe, Alexandra McDonald, Fabiano A. Gomes, Elisa Brietzke
Summary: Current treatments for adult ADHD are limited, but changes in lifestyle could have a positive impact. The most promising diets are healthy diets and the Few-Foods Diet. Studies should consider confounders, biases, and search for mechanisms of action.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Miriam Longo, Daniel Jerico, Karol M. Cordoba, Jose Ignacio Riezu-Boj, Raquel Urtasun, Isabel Solares, Ana Sampedro, Maria Collantes, Ivan Penuelas, Maria Jesus Moreno-Aliaga, Matias A. avila, Elena Di Pierro, Miguel Barajas, Fermin I. Milagro, Paola Dongiovanni, Antonio Fontanellas
Summary: This study aimed to evaluate the impact of nutritional interventions on carbohydrate dysfunctions in a mouse model of AIP. The addition of Bacillus coagulans spores in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, improving glucose tolerance and hyperinsulinemia, and promoting fat disposal in adipose tissue. Probiotic supplementation also improved muscle glucose uptake. In conclusion, probiotics provide a safe and efficient option to manage insulin resistance associated with AIP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Luisa Lampignano, Nicola Quaranta, Ilaria Bortone, Sarah Tirelli, Roberta Zupo, Fabio Castellana, Rossella Donghia, Vito Guerra, Chiara Griseta, Pasqua Letizia Pesole, Marcello Chieppa, Giancarlo Logroscino, Madia Lozupone, Anna Maria Cisternino, Giovanni De Pergola, Francesco Panza, Gianluigi Giannelli, Heiner Boeing, Rodolfo Sardone
Summary: This study investigated the relationship between dietary habits and age-related CAPD in a population over 65 years old. Findings showed that subjects with age-related CAPD consumed more dairy and olive oil, and less fruits. Additionally, dietary fiber was found to be inversely related to age-related CAPD. Further research from large and prospective population-based studies is needed to confirm these findings.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Marise B. Parent, Suzanne Higgs, Lucy G. Cheke, Scott E. Kanoski
Summary: The review highlights a bidirectional relationship between memory and eating in both humans and rodents. In humans, amnesia is linked to impaired processing of hunger cues and disrupted meal-related memory, while obesity is associated with hippocampal disturbances. Evidence from rodent studies suggests that hippocampal neural activity and endocrine/neuropeptide systems play roles in controlling meal-related memory and energy status cues. Furthermore, consumption of hypercaloric diets and obesity can disrupt these processes, leading to a potential vicious cycle contributing to diet-induced obesity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Justine Fam, Kelly J. Clemens, R. Fred Westbrook, Margaret J. Morris, Michael D. Kendig
Summary: This study found that diet-induced obesity significantly impacts rats' preference for sweet taste, but this is not due to differences in liking for the food.
Review
Biochemistry & Molecular Biology
Sarah-Jane Leigh, Caoimhe M. K. Lynch, Brian R. Healey Bird, Brendan T. Griffin, John F. Cryan, Gerard Clarke
Summary: The gut microbiota plays a crucial role in cancer therapy efficacy and adverse events. Baseline microbiota composition, microbiota modification, and antibiotics exposure are associated with cancer treatment response. Microbes can interact with cancer drugs through direct metabolism and modulation of liver metabolism and immune function.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthias Klugmann, Elizabeth Kalotay, Fabien Delerue, Lars M. Ittner, Andre Bongers, Josephine Yu, Margaret J. Morris, Gary D. Housley, Dominik Frohlich
Summary: This study identifies the phenotypes of the DARS1(M256L) mutation genotype associated with HBSL in mice, providing an important model for further study of HBSL.
NEUROCHEMICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Md Jakir Hossain, Michael D. Kendig, Meg E. Letton, Margaret J. Morris, Ria Arnold
Summary: This review examines the phenotyping of DPN in rat models of T2DM against the 'Neurodiab' criteria and discusses how DPN phenotypes differ between models, diabetes duration, and sex. Despite the introduction of Neurodiab guidelines, the use of diet and chemically induced T2DM models has surpassed that of transgenic models in recent years, with no substantial increase in the number of studies assessing all key DPN endpoints. The recommendation is to adhere to Neurodiab guidelines for creating better animal models of DPN to accelerate translation and drug development.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Nutrition & Dietetics
Md Mustahsan Billah, Saroj Khatiwada, Virginie Lecomte, Margaret J. Morris, Christopher A. Maloney
Summary: This study investigated the effects of an antioxidant-based micronutrient supplement on sperm and testicular oxidative damage in male rats fed a high-fat diet. The results suggest that the supplement may reduce oxidative damage in sperm and testis and improve testicular antioxidant capacity.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Samuel G. Towarnicki, Neil A. Youngson, Susan M. Corley, Jus C. St John, Richard G. Melvin, Nigel Turner, Margaret J. Morris, J. William O. Ballard
Summary: Studies have shown that ancestral life experiences, particularly stress and diet, can influence the growth, metabolism, and behavior of future generations. This research focuses on the non-genetic inheritance between fertilization and adulthood, revealing that ancestral dietary macronutrient composition and quantity can impact the developmental timing of descendants through changes in specific signaling pathways.
Article
Genetics & Heredity
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Summary: The research demonstrates that metabolically driven histone hyperacetylation in steatotic hepatocytes can increase DNA damage, thus initiating the development of HCC.
Article
Food Science & Technology
Michael D. Kendig, Kyoko Hasebe, Aynaz Tajaddini, Nadeem O. Kaakoush, R. Frederick Westbrook, Margaret J. Morris
Summary: This study examines the effects of a diet switch intervention in a rat model of maternal obesity. The results show that the intervention leads to reductions in body weight and adiposity, improvements in place recognition memory, and changes in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Bruna Panizzutti, David Skvarc, Sylvia Lin, Sarah Croce, Alcy Meehan, Chiara Cristina Bortolasci, Wolfgang Marx, Adam J. Walker, Kyoko Hasebe, Bianca E. Kavanagh, Margaret J. Morris, Mohammadreza Mohebbi, Alyna Turner, Laura Gray, Lesley Berk, Ken Walder, Michael Berk, Olivia M. Dean
Summary: Minocycline has been found to have anti-inflammatory, antioxidant, and anti-apoptotic properties, which has led to a renewed interest in using it as an adjunctive treatment for psychiatric and neurological conditions. A systematic review and meta-analysis of the available data from clinical trials using minocycline was conducted, showing limited and difficult to interpret results for most conditions, but suggesting an overall benefit for using minocycline as an adjunctive treatment for schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Michael D. Kendig, Sarah-Jane Leigh, Kyoko Hasebe, Nadeem O. Kaakoush, R. Fred Westbrook, Margaret J. Morris
Summary: This study aimed to investigate the effects of diet cycling on cognition and fecal microbiota. The results showed that switching to a regular diet for at least 11 days could reduce the impairment in place recognition memory caused by a high-fat, high-sugar cafeteria diet. Moreover, longer cycles of unhealthy diet exposure worsened cognitive deficits and led to larger shifts in gut microbiota composition. The results suggest that at least a week of healthy diet is necessary for recovery of cognitive deficits.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Correction
Genetics & Heredity
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Review
Biochemistry & Molecular Biology
Yue Huang, Jun Wei, Antony Cooper, Margaret J. Morris
Summary: Parkinson's disease (PD) is a common neurodegenerative movement disorder in the elderly. The pathogenesis of PD is not fully understood, and there are currently no medications available to halt disease progression. Identification of causative genes and those associated with susceptibility to PD is crucial for the development of new therapeutic approaches. By reviewing relevant data, this study explores the roles of different genes and molecular pathways in the pathogenesis of PD, with the aim of improving consultation and personalized medicine for PD patients in the future.
Meeting Abstract
Endocrinology & Metabolism
M. J. Hossain, M. D. Kendig, M. J. Morris, R. Arnold
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Microbiology
Kyoko Hasebe, Michael D. Kendig, Nadeem O. Kaakoush, Aynaz Tajaddini, R. Frederick Westbrook, Margaret J. Morris
Summary: This study investigates the effects of maternal diet quality on the longitudinal maturation of gut microbiota in offspring. The results show that introducing solid food at weaning triggers the maturation of gut microbiota in rats, and a western-style, high-choice cafeteria diet has a significant impact on offspring gut microbiota. However, this impact is modulated by maternal diet history.
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)