Article
Infectious Diseases
Alexandra L. Hernandez, Rajiv Karthik, Murugesan Sivasubramanian, Anantharam Raghavendran, Shelly Lensing, Jeannette Y. Lee, Priya Abraham, Dilip Mathai, Joel M. Palefsky
Summary: This study found a high prevalence of oral HPV infection among HIV-positive Indian MSM, but oncogenic anogenital HPV types were relatively uncommon in this population. It is unknown what the impact of this distribution of oral HPV will be on oropharyngeal cancers.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Wojciech Pinkas, Mateusz Jankowski, Waldemar Wierzba
Summary: This study assessed the attitudes towards HPV vaccination among adults in Poland and found a low level of public awareness of HPV vaccination as a cancer prevention method.
Article
Biotechnology & Applied Microbiology
Emeline Brosset, Lisa Fressard, Chloe Cogordan, Aurelie Bocquier, Margot Annequin, Michel Bourrelly, Jean Constance, David Michels, Marion Mora, Stephane Morel, Camilla Oliveri, Gwenaelle Maradan, Cyril Berenger, Bruno Spire, Pierre Verger
Summary: Vaccine hesitancy is prevalent among French MSM for hepatitis B, hepatitis A, and human papillomavirus vaccines, with variations based on education, financial situation, and age. Addressing their concerns, improving their knowledge, and motivating them to get vaccinated are important public health priorities.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Medicine, General & Internal
Ayane Cristine Alves Sarmento, Fabiola S. Fernandes, Ana Paula Ferreira Costa, Kleyton Santos Medeiros, Janaina Cristina Crispim, Ana Katherine Goncalves
Summary: Menopause is a physiological phenomenon secondary to decreased ovarian follicular reserve, leading to vaginal symptoms. Topical hormone therapy is commonly used for postmenopausal vaginal symptoms, but not suitable for women with a history of breast cancer, oestrogen-sensitive tumors, and thromboembolism. Physical methods like laser and RF have been used for vaginal mucosa treatment.
Article
Medicine, General & Internal
Bridget Steele, Michelle Degli Esposti, Pete Mandeville, Gillian Hamnett, Elizabeth Nye, David K. Humphreys
Summary: This study aims to investigate the prevalence of sexual harassment and violence among undergraduate and graduate students at the University of Oxford in the UK, and examine the association with ethnicity, gender identity, and sexual orientation. Ethical approval has been obtained for the research, and findings will be disseminated through peer-reviewed journals and conference presentations, as well as a report shared with Oxford University students.
Article
Immunology
Alpamys Issanov, Mohammad Ehsanul Karim, Gulzhanat Aimagambetova, Trevor J. B. Dummer
Summary: This study aimed to evaluate the association between HPV vaccination and HPV-related cancers among US adults. While no statistically significant association was found, the results suggest that vaccinated adults may have lower odds of developing HPV-related cancers.
Article
Medicine, General & Internal
Tiffany R. Phillips, Christopher K. Fairley, Catriona S. Bradshaw, Marjan Tabesh, Kate Maddaford, Jane S. Hocking, Eric P. F. Chow
Summary: The study showed that the frequency of mouthwash use increases with age, with individuals over 35 years old more likely to be frequent users. However, there was no significant association found between sexual behavior and mouthwash use among heterosexual individuals in the study.
Article
Oncology
Marjorie M. A. de Souza, Gunter Hartel, Catherine M. Olsen, David C. Whiteman, Annika Antonsson
Summary: This Australian-based study assessed the prevalence of oral HPV infection in Australian residents and found that the prevalence was 7.2%. The study also found a strong association between oral HPV infection and sexual behaviors, and suggested that HPV vaccination may result in a lower risk of infection with nonavalent HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao, Wen Chen
Summary: This study developed a more accurate model for cervical cancer screening, utilizing multiple predictors and conducting external validations in different cohorts. The results showed that the model had better clinical performance compared to routine screening methods, leading to reduced referral rates.
Article
Oncology
Hunter Hinton, Spencer Coleman, J. R. Salem, Karl Kingsley
Summary: This study conducted one of the first oral prevalence studies of high-risk HPV strains among a multi-ethnic patient population at a public dental school in Nevada. The results revealed that a significant percentage of children and adults harbored high-risk HPV strains, mostly within the recommended vaccination age range.
Article
Oncology
Annika Antonsson, Marjorie de Souza, Zoe C. Wood, Angela Carroll, Kim Van, Lachlan Paterson, Nirmala Pandeya, David C. Whiteman
Summary: Oral infection with HPV is likely to contribute to the increasing incidence of oropharyngeal squamous cell carcinoma, and is associated with sexual behaviors. New oral infections with HPV in the sample were not rare, with most infections being cleared but not universally, suggesting a reservoir of infection may predispose to oropharyngeal carcinogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Virology
Sadhbh O'Rourke, Niamh O'Flaherty, Dermot Coyne, Almida Lynam, Susan Clarke, Siobhan O'Dea, Sarah Fitzpatrick, Jeff Connell, Brendan Crowley
Summary: This study found that the seroprevalence of Human herpesvirus 8 (HHV-8) in the Irish population is low, but higher among men who have sex with men (MSM), especially those who are HIV-positive.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Mary Katherine Sammons, Matthew Gaskins, Frank Kutscha, Alexander Nast, Ricardo Niklas Werner
Summary: The study found that HIV-specialists had greater self-assessed knowledge, more positive attitudes towards PrEP, and provided more proactive PrEP advice to at-risk populations than non-HIV-specialists. These findings suggest that targeted training and patient-centered information materials could improve PrEP implementation, especially in rural areas.
Article
Immunology
Gulzhanat Aimagambetova, Aisha Babi, Torgyn Issa, Alpamys Issanov
Summary: The study found that Kazakhstani women have contrasting attitudes towards the HPV vaccine, with approximately half having positive attitudes and almost half having negative or neutral attitudes. Women with low education levels, high number of children, belief in alternative medicine, and impacted by the failed vaccination program in 2013 are less likely to have a positive attitude towards the vaccine.
Article
Virology
Yusha Chen, Suyu Li, Jinwen Zheng, Huifeng Xue, Jiancui Chen, Xiangqin Zheng
Summary: Multiple human papillomavirus (HPV) infections are common and controversial in their impact on cervical lesions. This study investigated the association between multiple HPV infections and cervical lesions, and found that single HR-HPV coinfected with LR-HPV may reduce the risk of high-grade cervical lesions.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Abraham M. Getaneh, Xiao Li, Zhuxin Mao, Caroline K. Johannesen, Elisa Barbieri, Jojanneke van Summeren, Xin Wang, Sabine Tong, Eugenio Baraldi, Emily Phijffer, Caterina Rizzo, Maarten van Wijhe, Terho Heikkinen, Louis Bont, Lander Willem, Mark Jit, Philippe Beutels, Joke Bilcke
Summary: This study evaluates the cost-effectiveness of potential mAb and MI interventions against RSV in infants in six European countries. The results show that the choice between MI or mAb depends on factors such as protection level, price, and feasibility for different countries and scenarios.
Article
Economics
Xiao Li, David Hodgson, Julien Flaig, Alexia Kieffer, William L. Herring, Hadi Beyhaghi, Lander Willem, Mark Jit, Joke Bilcke, Philippe Beutels
Summary: This study compared static and dynamic models to analyze the cost-effectiveness of maternal vaccine (MV) and monoclonal antibody (mAb) interventions against respiratory syncytial virus (RSV). The static models estimated fewer medically attended cases averted, but showed significant cost savings and quality-adjusted life years (QALYs) gained. On the other hand, the dynamic models estimated more cases averted, especially non-medically attended cases. These differences can be explained by the model types and assumptions on non-medical burden and intervention effectiveness over time.
Article
Medicine, General & Internal
Tingting You, Xuelian Zhao, Shangying Hu, Meng Gao, Yang Liu, Yong Zhang, Youlin Qiao, Mark Jit, Fanghui Zhao
Summary: The key barrier to cervical cancer elimination in China is low HPV vaccine uptake due to supply constraints, high prices, and dose restrictions. This study explores optimal vaccination strategies for maximizing health and economic benefits under different supply and dose schedules.
Article
Infectious Diseases
Yumeng Du, Chenqi Jin, Mark Jit, Tracey Chantler, Leesa Lin, Heidi J. Larson, Jing Li, Wenfeng Gong, Fan Yang, Nina Ren, Weibin Cheng, Yi Zhou, Weiming Tang, Joseph D. Tucker, Dan Wu
Summary: This study aimed to understand the factors associated with influenza vaccine uptake among children and older people in China. The results showed that the vaccination rate was higher in the subsidized group compared to the self-paid group. In the self-paid group, prior vaccination experiences and trust in providers' advice were associated with higher vaccine uptake, while in the subsidized group, marital status, perception of vaccine effectiveness, and previous experience of influenza-like illnesses in the family were associated with vaccine uptake.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Horace C. W. Choi, Kathy Leung, Karen K. L. Chan, Yuan Bai, Mark Jit, Joseph T. T. Wu
Summary: This study aimed to evaluate the cost-effectiveness of determining the optimal screening strategies for vaccinated and unvaccinated cohorts. It found that HPV testing is a cost-effective alternative to cytology for vaccinated cohorts, and the optimal screening frequency depends on vaccine uptake.
Article
Medicine, General & Internal
Mihaly Koltai, Jocelyn Moyes, Bryan Nyawanda, Joyce Nyiro, Patrick K. Munywoki, Stefano Tempia, Xiao Li, Marina Antillon, Joke Bilcke, Stefan Flasche, Philippe Beutels, D. James Nokes, Cheryl Cohen, Mark Jit
Summary: Respiratory syncytial virus (RSV) causes a significant burden of acute lower respiratory infection in children under 5 years, especially in low- and middle-income countries. Maternal vaccine (MV) and next-generation monoclonal antibody (mAb) candidates have shown effectiveness in reducing RSV disease. Original hospital-based data from South Africa and Kenya suggest that interventions against RSV disease may be more cost-effective than previously estimated.
Article
Medicine, General & Internal
Emily Herrett, Keith Tomlin, Liang-Yu Lin, Laurie A. Tomlinson, Mark Jit, Andrew Briggs, Michael Marks, Frank Sandmann, John Parry, Christopher Bates, Jessica Morley, Seb Bacon, Benjamin Butler-Cole, Viyaasan Mahalingasivam, Alan Dennison, Deb Smith, Ethan Gabriel, Amir Mehrkar, Ben Goldacre, Liam Smeeth, Rosalind M. M. Eggo
Summary: This study aims to understand the impact of long COVID on health-related quality of life and productivity in English primary care patients. Participants will be asked to complete questionnaires through a smartphone app, covering aspects such as HRQoL, productivity, and symptoms of long COVID. Analysis will be conducted using the OpenSAFELY data platform to estimate the impact on HRQoL, productivity, and cost to the NHS.
Article
Medicine, General & Internal
Simon Procter, Bronner P. Goncalves, Proma Paul, Jaya Chandna, Farah Seedat, Artemis Koukounari, Raymond Hutubessy, Caroline Trotter, Joy E. Lawn, Mark Jit
Summary: This study assessed the health impact and cost-effectiveness of GBS maternal vaccination globally. The results showed that a GBS maternal vaccination program could significantly reduce the burden of infant mortality and disability, and it is a cost-effective intervention.
Article
Medicine, General & Internal
Naomi R. Waterlow, Simon R. Procter, Rosalind M. Eggo, Mark Jit
Summary: In a recent study, we examined the potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya. A commentary on our study highlights the broader benefits of vaccination on cost-effectiveness. While we agree with many points raised in the commentary, it raises interesting discussion points on model complexity, assumptions, and data availability, which have implications beyond this specific study.
Article
Medicine, General & Internal
Kiesha Prem, Yoon Hong Choi, Elodie Benard, Emily A. Burger, Liza Hadley, Jean-Francois Laprise, Mary Caroline Regan, Melanie Drolet, Stephen Sy, Kaja Abbas, Allison Portnoy, Jane J. Kim, Marc Brisson, Mark Jit
Summary: Using three independent HPV transmission models, the study estimated the long-term health benefits and cost-effectiveness of one-dose versus two-dose HPV vaccination. Results showed that one-dose vaccination had similar health benefits to a two-dose programme and could prevent millions of cervical cancer cases. The cost of the second dose was relatively low across all income groups.
Article
Medicine, General & Internal
Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow, Siobhan Botwright
Summary: The Full Value of Vaccines Assessments (FVVA) framework provides guidance for assessing and communicating the value of vaccines, addressing economic obstacles and promoting investment in vaccines. It aims to enhance decision-making and coordination among stakeholders, leading to more sustainable and equitable impacts of vaccines.
Article
Immunology
Meagan C. Fitzpatrick, Rachel S. Laufer, Ranju Baral, Amanda J. Driscoll, Daniel R. Feikin, Jessica A. Fleming, Mark Jit, Sonnie Kim, Mihaly Koltai, You Li, Xiao Li, Harish Nair, Kathleen M. Neuzil, Clint Pecenka, Erin Sparrow, Padmini Srikantiah, Justin R. Ortiz
Summary: Policymakers often rely on impact and cost-effectiveness evaluations to inform decisions about the introduction of health interventions in LMICs; however, cost-effectiveness results for the same health intervention can differ by the choice of parameter inputs, modelling assumptions, and geography. This report summarizes a two-day virtual consultation convened by WHO to review and discuss existing cost-effectiveness analyses for RSV prevention in LMICs, in order to identify influential inputs and data limitations, and recommend future research priorities to improve RSV prevention impact estimates in LMICs.
Article
Medicine, General & Internal
Allison Portnoy, Jean-Louis Arcand, Rebecca A. A. Clark, Chathika K. K. Weerasuriya, Christinah Mukandavire, Roel Bakker, Edith Patouillard, Nebiat Gebreselassie, Matteo Zignol, Mark Jit, Richard G. G. White, Nicolas A. A. Menzies
Summary: This study aimed to estimate the impact of introducing novel TB vaccines on GDP growth in 105 LMICs. The results showed that introducing new TB vaccines could increase economic growth in these countries, with a more significant effect in countries with higher current TB incidence.
Article
Medicine, General & Internal
Marina Antillon, Xiao Li, Lander Willem, Joke C. Bilcke, - C. RESCEU investigators, Mark Jit, Philippe Beutels
Summary: This study aimed to assess the burden of respiratory syncytial virus (RSV) on children under 5 years old. The findings showed that infants under 6 months old, especially in low-income and middle-income countries, are at higher risk of infection, hospitalization, and death. Therefore, the study suggests implementing multiple measures to reduce the burden on this population.
Article
Medicine, Research & Experimental
Zhiyuan Hou, Xiaozhen Lai, Yang Liu, Mark Jit, Heidi J. Larson, Hai Fang
Summary: This study assessed the impact of the 2018 Changchun Changsheng vaccine incident on childhood vaccination in China, finding that the vaccine involved in the incident was delayed in its administration, but there was minimal effect on other vaccines.
COMMUNICATIONS MEDICINE
(2023)
