Editorial Material
Multidisciplinary Sciences
Laurence C. Chen, Yvonne Y. Chen
Summary: Key nutrients for immune cells are lacking in tumors, but engineered cancer-invasive bacteria can convert tumor waste into metabolic fuel to enhance anti-cancer immune responses in mice.
Review
Clinical Neurology
Ruichong Ma, Martin J. B. Taphoorn, Puneet Plaha
Summary: Glioblastoma is the most common and malignant primary brain tumor in adults, with poor prognosis despite current standard therapy. However, advancements in surgical technology and understanding of the biology of GB have led to increased rates of safe maximal resection and identified potential targets for new treatments like immunotherapy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Reza Naghavian, Wolfgang Faigle, Pietro Oldrati, Jian Wang, Nora C. Toussaint, Yuhan Qiu, Gioele Medici, Marcel Wacker, Lena K. Freudenmann, Pierre-Emmanuel Bonte, Michael Weller, Luca Regli, Sebastian Amigorena, Hans-Georg Rammensee, Juliane S. Walz, Silvio D. Brugger, Malte Mohme, Yingdong Zhao, Mireia Sospedra, Marian C. Neidert, Roland Martin
Summary: Microbial organisms play important roles in physiological processes in the human body and can affect the response to immune checkpoint inhibitors. This study investigates the role of microbial organisms in immune reactivity against glioblastoma. The findings suggest that bacterial pathogens and gut microbiota may be involved in specific immune recognition of tumor antigens, revealing potential for personalized tumor vaccination approaches.
Review
Medicine, General & Internal
Shufei Yu, Shuyang Zhang, Haiyan Xu, Guangjian Yang, Fei Xu, Liang Yang, Duo Chen, Guangyu An, Yan Wang
Summary: This meta-analysis investigates the efficacy of immune checkpoint inhibitors (ICIs) compared to chemotherapy in lung cancer patients with liver or brain metastases. The results show that ICIs are more effective than chemotherapy in these patients, with less benefit observed in patients with liver metastases and greater benefit observed in patients with brain metastases, specifically in non-small cell lung cancer patients.
Review
Immunology
Mengtian Wan, Yuzhu Ding, Zheng Li, Xu Wang, Min Xu
Summary: This paper discusses metabolic reprogramming in tumor cells and the influence of metabolite by-products on the immune microenvironment, providing novel insights into tumor immunotherapy.
Article
Oncology
Anna M. Bielecka-Wajdman, Tomasz Ludyga, Daria Smyk, Wojciech Smyk, Magdalena Mularska, Patrycja Swiderek, Wojciech Majewski, Christina Susanne Mullins, Michael Linnebacher, Ewa Obuchowicz
Summary: The weakness of glucose metabolism is found to be related to the invasiveness and growth of GBM. DXM may support GBM energy metabolism and contribute to its recurrence. Under low oxygen and high glucose conditions, the study shows that DXM attenuates the cytotoxic effect of TMZ and intensifies malignancy features in GBM cell lines. A preliminary retrospective analysis indicates a correlation between serum glucose levels and Ki-67 expression in GBM patients.
Review
Oncology
Amir R. Afshari, Mehdi Sanati, Samaneh Aminyavari, Farzaneh Shakeri, Bahram Bibak, Zakieh Keshavarzi, Mohammad Soukhtanloo, Mohammad Jalili-Nik, Mohammad Montazami Sadeghi, Hamid Mollazadeh, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Dexamethasone is a drug used to treat glioblastoma multiforme, with both anti-tumoral effects and undesirable side effects which may impact patient survival.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi Jiang, Yuejie Xu, Chang Zheng, Lei Ye, Ping Jiang, Sara Malik, Guifang Xu, Qian Zhou, Mingming Zhang
Summary: This study reveals that the gut bacterium A. muciniphila is involved in the post-translational modification of proteins in colorectal cancer (CRC). A specific enzyme, Amuc_2172, is capable of acetylating histone H3 and promoting the expression and secretion of HSP70 in cancer cells, leading to enhanced immune activity of CTLs. Furthermore, bioengineered nanoparticles provide a potential drug delivery strategy for the treatment of CRC.
Article
Oncology
Xu Guan, Pu Cheng, Ran Wei, Jiangtao Li, Shuai Jiao, Zhixun Zhao, Haipeng Chen, Zheng Liu, Zheng Jiang, Zhaoxu Zheng, Shuangmei Zou, Xishan Wang
Summary: Enlarged TDLN in non-metastatic CRC exhibits an activated anti-tumour immune profile and is associated with favorable survival outcomes. The presence of numerous immune-activating pathways and higher numbers of CD3+ and CD8+ T cells in L-TDLN suggests its potential as a prognostic indicator.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Artur Mezheyeuski, Max Backman, Johanna Mattsson, Alfonso Martin-Bernabe, Chatarina Larsson, Ina Hrynchyk, Klara Hammarstrom, Simon Strom, Joakim Ekstrom, Siarhei Mauchanski, Salome Khelashvili, Amanda Lindberg, Margret Agnarsdottir, Per-Henrik Edqvist, Jutta Huvila, Ulrika Segersten, Per-Uno Malmstrom, Johan Botling, Bjoern Nodin, Charlotta Hedner, David Borg, Jenny Brandstedt, Hanna Sartor, Karin Leandersson, Bengt Glimelius, Anna Portyanko, Fredrik Ponten, Karin Jirstrom, Patrick Micke, Tobias Sjoblom
Summary: We evaluated 15 immune cell classes in 1481 tumor samples and generated an immune activation signature (SIA) based on the prognostic information of CD8+ lymphocytes and CD68+CD163+ macrophages in various cancer types. The SIA was associated with patient survival and had predictive value for response to checkpoint inhibitor therapy.
Article
Ophthalmology
Lata Singh, Mithalesh Kumar Singh, Moshahid Alam Rizvi, Neelam Pushker, Sameer Bakhshi, Seema Sen, Seema Kashyap
Summary: This study investigated the expression of PD-1 and PD-L1 proteins in the tumor microenvironment of SGC and found that PD-L1 expression was higher in tumor cells than in stromal cells, while the expression of tPD-1 was associated with poor survival. These results suggest that the PD-1/PD-L1 pathway plays important roles in the tumor microenvironment of SGC.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Clinical Neurology
Rita Perelroizen, Bar Philosof, Noga Budick-Harmelin, Tom Chernobylsky, Ariel Ron, Rotem Katzir, Dor Shimon, Adi Tessler, Orit Adir, Anat Gaoni-Yogev, Tom Meyer, Avivit Krivitsky, Nuphar Shidlovsky, Asaf Madi, Eytan Ruppin, Lior Mayo
Summary: This study reveals that depletion of reactive astrocytes can lead to regression of glioblastoma and prolonged survival. It also demonstrates that glioma cells depend on astrocyte-derived cholesterol for survival. The findings highlight the important role of astrocytes in controlling the pathogenicity of glioblastoma.
Review
Biochemistry & Molecular Biology
Laura Benecke, Mali Coray, Sandra Umbricht, Dapi Chiang, Fabricio Figueiro, Laurent Muller
Summary: Glioblastomas, highly aggressive tumors with low survival rates, create an immunosuppressive microenvironment through the transportation of biomolecules by exosomes. Recent studies have shown the significant impact of tumor-derived exosomes on immune cells, highlighting their potential as diagnostic tools and therapeutic targets for aggressive tumor cells like glioblastomas. Exosomes serve as important instruments for molecular understanding of tumors given their structural and functional properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
J. Bryan Iorgulescu, Prafulla C. Gokhale, Maria C. Speranza, Benjamin K. Eschle, Michael J. Poitras, Margaret K. Wilkens, Kara M. Soroko, Chhayheng Chhoeu, Aine Knott, Yan Gao, Mary Jane Lim-Fat, Gregory J. Baker, Dennis M. Bonal, Quang-De Nguyen, Gareth R. L. Grant, Keith L. Ligon, Peter K. Sorger, E. Antonio Chiocca, Ana C. Anderson, Paul T. Kirschmeier, Arlene H. Sharpe, Gordon J. Freeman, David A. Reardon
Summary: The study indicates that concurrent dexamethasone therapy may have detrimental effects on immunotherapeutic approaches in patients with glioblastoma, by reducing T-lymphocyte numbers and functionality, as well as decreasing myeloid and natural killer cell populations.
CLINICAL CANCER RESEARCH
(2021)
Review
Immunology
Angela Fernandes, Catarina M. Azevedo, Mariana C. Silva, Guilherme Faria, Carolina S. Dantas, Manuel M. Vicente, Salome S. Pinho
Summary: Cells are covered with sugar chains called glycocalyx. Changes in cellular glycosylation are associated with cancer and affect tumor immune responses. Glycans play a crucial role in T-cell development, differentiation, activation, and signaling. The diverse glycans on the surface of T cells regulate the interactions between T cells and cancer cells, fine-tuning the anti-tumor immune response.
Review
Oncology
Eric T. Wong, Edwin Lok, Kenneth D. Swanson
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2015)
Review
Engineering, Biomedical
Edwin Lok, Kenneth D. Swanson, Eric T. Wong
EXPERT REVIEW OF MEDICAL DEVICES
(2015)
Article
Oncology
Edwin Lok, Van Hua, Eric T. Wong
Article
Oncology
Eric T. Wong, Edwin Lok, Kenneth D. Swanson
Article
Clinical Neurology
Ekokobe Fonkem, Samantha Dayawansa, Edana Stroberg, Edwin Lok, Paul C. Bricker, Batool Kirmani, Eric T. Wong, Jason H. Huang
Review
Clinical Neurology
Kenneth D. Swanson, Edwin Lok, Eric T. Wong
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2016)
Article
Oncology
Edwin Lok, Pyay San, Van Hua, Melissa Phung, Eric T. Wong
Review
Oncology
Joshua J. Timmons, Kisa Zhang, Johnson Fong, Edwin Lok, Kenneth D. Swanson, Shiva Gautam, Eric T. Wong
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2018)
Article
Oncology
Edwin Lok, Amy S. Chung, Kenneth D. Swanson, Eric T. Wong
Article
Oncology
Eric T. Wong, Edwin Lok, Kenneth D. Swanson, Shiva Gautam, Herbert H. Engelhard, Frank Lieberman, Sophie Taillibert, Zvi Ram, John L. Villano
Article
Multidisciplinary Sciences
Mercedes M. Riley, Pyay San, Edwin Lok, Kenneth D. Swanson, Eric T. Wong
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Oncology
Edwin Lok, Pyay San, Olivia Liang, Victoria White, Eric T. Wong
JOURNAL OF NEURO-ONCOLOGY
(2020)
Article
Oncology
Edwin Lok, Pyay San, Victoria White, Olivia Liang, Page C. Widick, Sindhu Pisati Reddy, Eric T. Wong
Summary: Modeling studies have been conducted to better understand the distribution of TTFields therapy in the human body, revealing that the intensity of the electric field is influenced by surrounding anatomical structures, as well as the conductivity of the specific area and the placement of arrays.
ADVANCES IN RADIATION ONCOLOGY
(2021)
Article
Engineering, Biomedical
Joshua J. Timmons, Edwin Lok, Pyay San, Kevin Bui, Eric T. Wong
PHYSICS IN MEDICINE AND BIOLOGY
(2017)