Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors

Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation

(2019) Lingling Xu et al.   Oxidative Medicine and Cellular Longevity

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease

(2019) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine

(2019) Mengyang Feng et al.   NEUROSCIENCE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis

(2019) Juan Suárez et al.   PSYCHONEUROENDOCRINOLOGY

Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice

(2018) Ding Yuan et al.   Archives of Medical Science

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice

(2018) Jie Feng et al.   CNS Neuroscience & Therapeutics

Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat

(2018) Fatemeh Mirzaei et al.   FOOD AND CHEMICAL TOXICOLOGY

Eating as a motivated behavior: modulatory effect of high fat diets on energy homeostasis, reward processing, and neuroinflammation

(2018) Michael J. Butler et al.   Integrative Zoology

Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment

(2018) Zhi Wang et al.   Journal of Neuroinflammation

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation

(2018) Ruth A. Wood et al.   NATURE

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

(2018) Francesca Romana Rizzo et al.   NEURAL PLASTICITY

Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet

(2018) Lorena Gimenez da Silva-Santi et al.   Nutrients

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation

(2018) Chan Hee Lee et al.   Cell Reports

The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity

(2018) Joanne M. Gladding et al.   Frontiers in Endocrinology

Ketamine may exert antidepressant effects via suppressing NLRP3 inflammasome to upregulate AMPA receptors

(2018) Jia-Mei Li et al.   NEUROPHARMACOLOGY

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac

(2017) Fernando J. Bustos et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

(2017) M-X Li et al.   MOLECULAR PSYCHIATRY

The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning

(2017) Zikai Zhou et al.   NATURE NEUROSCIENCE

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

(2017) Sarah J. Spencer et al.   NEUROBIOLOGY OF AGING

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

(2017) Camila P. Almeida-Suhett et al.   PHYSIOLOGY & BEHAVIOR

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuromodulatory Effect of G s- or G q-Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca2+/Calcineurin/cAMP Response Element-Binding Protein-Regulated Transcriptional Coactivator 1 Pathway to Effectively Induce Brain-Derived Neurotrophic Factor Expression in Neurons

(2015) M. Fukuchi et al.   JOURNAL OF NEUROSCIENCE

Protective effect of saponins extract fromPanax japonicuson myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation

(2014) Na Wei et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Obesity and cognitive decline: role of inflammation and vascular changes

(2014) Jason C. D. Nguyen et al.   Frontiers in Neuroscience

Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes

(2014) Nathalie Castanon et al.   Frontiers in Endocrinology

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

(2012) Haibo He et al.   JOURNAL OF ETHNOPHARMACOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

(2011) Anders S Kristensen et al.   NATURE NEUROSCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY