Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

(2020) Saara Hämälistö et al.   Nature Communications

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy

(2020) Francesco Di Matteo et al.   EMBO Molecular Medicine

The phenomenal epigenome in neurodevelopmental disorders

(2020) Ummi Ciptasari et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Clipped histone H3 is integrated into nucleosomes of DNA replication genes in the human malaria parasite Plasmodium falciparum

(2019) Abril Marcela Herrera‐Solorio et al.   EMBO REPORTS

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility

(2019) Boaz Styr et al.   NEURON

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

(2019) Eduardo Penna et al.   Frontiers in Molecular Neuroscience

Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells

(2018) Martine Uittenbogaard et al.   Cell Death & Disease

Development and disease in a dish: the epigenetics of neurodevelopmental disorders

(2018) Emily MA Lewis et al.   Epigenomics

Modifying Chromatin by Histone Tail Clipping

(2018) Gajendra Kumar Azad et al.   JOURNAL OF MOLECULAR BIOLOGY

Corrigendum to: Contribution of histone N-terminal tails to the structure and stability of nucleosomes

(2018) Wakana Iwasaki et al.   FEBS Open Bio

Severe neurodegeneration, progressive cerebral volume loss and diffuse hypomyelination associated with a homozygous frameshift mutation in CSTB

(2017) Alan O'Brien et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

(2017) Fabio R. Melo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

CSTBnull mutation associated with microcephaly, early developmental delay, and severe dyskinesia

(2016) Grazia M.S. Mancini et al.   NEUROLOGY

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Histone proteolysis: A proposal for categorization into ‘clipping’ and ‘degradation’

(2014) Maarten Dhaenens et al.   BIOESSAYS

Abnormal microglial activation in theCstb−/−mouse, a model for progressive myoclonus epilepsy, EPM1

(2014) Olesya Okuneva et al.   GLIA

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

(2014) Ema F. Torrado et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia

(2014) Katarina Maher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Alterations in the Cerebellum and Granule Neurons of Cstb−/− Mouse Are Associated with Early Synaptic Changes and Inflammation

(2014) Tarja Joensuu et al.   PLoS One

Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study

(2014) Otto Manninen et al.   PLoS One

Cleavage of Histone 3 by Cathepsin D in the Involuting Mammary Gland

(2014) Zhila Khalkhali-Ellis et al.   PLoS One

Identification of histone H3 clipping activity in human embryonic stem cells

(2014) Liesbeth Vossaert et al.   Stem Cell Research

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

(2014) Luis F. Duarte et al.   Nature Communications

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Clipping of Flexible Tails of Histones H3 and H4 Affects the Structure and Dynamics of the Nucleosome

(2013) Nathan P. Nurse et al.   BIOPHYSICAL JOURNAL

Mutations inSDHDlead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency

(2013) Christopher Benjamin Jackson et al.   JOURNAL OF MEDICAL GENETICS

Quantitative single-cell RNA-seq with unique molecular identifiers

(2013) Saiful Islam et al.   NATURE METHODS

Solution Scattering and FRET Studies on Nucleosomes Reveal DNA Unwrapping Effects of H3 and H4 Tail Removal

(2013) Kurt Andresen et al.   PLoS One

White Matter Degeneration with Unverricht-Lundborg Progressive Myoclonus Epilepsy: A Translational Diffusion-Tensor Imaging Study in Patients and Cystatin B–Deficient Mice

(2013) Otto Manninen et al.   RADIOLOGY

Electroclinical presentation and genotype-phenotype relationships in patients with Unverricht-Lundborg disease carrying compound heterozygousCSTBpoint and indel mutations

(2012) Laura Canafoglia et al.   EPILEPSIA

Loss of cortical GABA terminals in Unverricht–Lundborg disease

(2012) Andrea Buzzi et al.   NEUROBIOLOGY OF DISEASE

The Protease Degrading Sperm Histones Post-Fertilization in Sea Urchin Eggs Is a Nuclear Cathepsin L That Is Further Required for Embryo Development

(2012) Violeta Morin et al.   PLoS One

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq

(2011) S. Islam et al.   GENOME RESEARCH

Early Microglial Activation Precedes Neuronal Loss in the Brain of theCstb−/−Mouse Model of Progressive Myoclonus Epilepsy, EPM1

(2011) Saara Tegelberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Severer Phenotype in Unverricht-Lundborg Disease (EPM1) Patients Compound Heterozygous for the Dodecamer Repeat Expansion and the c.202C>T Mutation in the CSTB Gene

(2011) Päivi Koskenkorva et al.   Neurodegenerative Diseases

Structural basis for the recognition and cleavage of histone H3 by cathepsin L

(2011) Melanie A. Adams-Cioaba et al.   Nature Communications

Stefin B Interacts with Histones and Cathepsin L in the Nucleus

(2010) Slavko Čeru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function

(2010) Marc Trimborn et al.   PLoS One

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

(2010) J. N. Pulvers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystatin B Deficiency Sensitizes Neurons to Oxidative Stress in Progressive Myoclonus Epilepsy, EPM1

(2009) M. K. Lehtinen et al.   JOURNAL OF NEUROSCIENCE

BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype

(2009) Ana Silva et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture

(2008) Yirui Sun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Histone H3 tail clipping regulates gene expression

(2008) Helena Santos-Rosa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY