Article
Cell Biology
Felipe Alexandre Machado, Roberta Figueiroa Souza, Vanessa Ribeiro Figliuolo, Robson Coutinho-Silva, Patricia Castelucci
Summary: This study examined the impact of P2X7 receptor deficiency on the distal colon myenteric plexus and enteric glial cells (EGCs) in mice with experimental ulcerative colitis. The results showed that ulcerative colitis affected the neuronal classes differently in wild-type (WT) and P2X7 receptor-deficient (KO) animals. The P2X7 receptor was found to potentially participate in and have a neuroprotective effect on enteric neurons in inflammatory bowel disease.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Immunology
Zi-xiao Zhao, Xi Yuan, Yan-yan Cui, Jun Liu, Jing Shen, Bi-ying Jin, Bing-cheng Feng, Yun-jiao Zhai, Meng-qi Zheng, Guan-jun Kou, Ru-chen Zhou, Li-xiang Li, Xiu-li Zuo, Shi-yang Li, Yan-qing Li
Summary: This study reveals that melatonin can alleviate type 2 immune response-associated colitis by suppressing inflammation, improving intestinal permeability, and modulating gut microbiota composition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Dan-Dan Zhu, Xue-Mei Tan, Li-Qing Lu, Si-Jia Yu, Ru-Li Jian, Xin-Fang Liang, Yi-Xuan Liao, Wei Fan, Luciia Barbier-Torres, Austin Yang, He-Ping Yang, Ting Liu
Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic that not only affects respiratory system but also leads to systemic inflammation and liver damage. NRF2 plays a crucial role in regulating antioxidant proteins in the context of COVID-19-induced inflammation and liver injury.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti
Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yan-Rong Li, Yan Li, Yuan Jin, Mang Xu, Hong-Wei Fan, Qian Zhang, Guo-He Tan, Jing Chen, Yun-Qing Li
Summary: This study investigates the effects of nitric oxide (NO) on colonic motility in a rat model of ulcerative colitis (UC), and the role of the enteric nervous system (ENS) in UC-related colonic motility. The results suggest that changes in the expression of nitric oxide synthase (NOS) in nitrergic neurons can influence colonic motility, and intervention in NOS activity may prevent colonic motor dysfunction in UC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Congjian Ma, Yanjun Deng, Ran Xiao, Fan Xu, Mobai Li, Qihai Gong, Jianmei Gao
Summary: The study found that Phlorizin (PHZ) has positive effects on fatigue, as it can alleviate fatigue and improve exercise endurance. PHZ achieves these effects by reducing reactive oxygen species, enhancing antioxidant enzyme activity, and regulating apoptosis-related factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Omayma A. Eldahshan, Yasmine M. Abdelkhalek, Magdy El Dahshan, Eman A. Ahmed, Jean-Marc Sabatier, Gaber E. -S. Batiha
Summary: COVID-19 is caused by SARS-CoV-2 and results in pulmonary and extra-pulmonary manifestations due to oxidative stress and hyperinflammation. The Nrf2 pathway plays a crucial role in mitigating viral toxicity and inflammation in COVID-19, and Nrf2 activators could be a potential therapeutic strategy for managing the disease.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Article
Medicine, Research & Experimental
Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Avinash Chandra Kushwaha, Atul Dev, Liku Biswal, Shyam Sunder Sharma, Subhasree Roy Choudhury, Surajit Karmakar
Summary: Melatonin significantly improves clinical symptoms of inflammatory bowel disease by reducing EZH2 expression, indicating its potential as a therapeutic target. The study highlights how melatonin regulates epigenetics to alleviate symptoms of IBD.
Article
Chemistry, Medicinal
Sichen Zhang, Chunguo Qian, Hailing Li, Zhimin Zhao, Jianchun Xian, Depo Yang
Summary: The antioxidant peptide DR12 from housefly pupae showed neuroprotective effects by reducing oxidative stress, upregulating endogenous antioxidants, and activating specific signaling pathways. DR12 may have potential therapeutic applications for neurodegenerative diseases.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Fen-Rong Chen, Yan Wang, Yan Cheng, Hai-Tao Shi, Hong Li, Miao Jia, Su-Mei Sha, Lei Dong
Summary: The study identified a long non-coding RNA AC006262.5 associated with HCC that promoted cell proliferation, migration, and invasiveness, and regulated miR-7855-5p to control the expression of BPY2C, forming a regulatory loop that affects the pathology of HCC. The novel findings suggest potential targets for HCC diagnosis and treatment.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haitao Shi, Lijuan Mao, Lianli Wang, Xiaojing Quan, Xiaoyu Xu, Yan Cheng, Shanshan Zhu, Fei Dai
Summary: The present study found that the incidence of SIBO is higher and OCTT is longer in patients with NAFLD. SIBO may be associated with elevated transaminase, hepatic steatosis, progression of liver fibrosis, and prolonged OCTT in NAFLD patients.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ameng Shi, Ting Li, Ying Zheng, Yahua Song, Haitao Wang, Na Wang, Lei Dong, Haitao Shi
Summary: CGA protects against HFD-induced hepatic steatosis and inflammation by regulating gut microbiota and increasing GLP-1 secretion through its anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mo Wang, Hai-Tao Shi, Xin-Xing Tantai, Lei Dong, Shi-Yang Ma
Summary: This study confirmed that water exchange colonoscopy significantly improved the cecal intubation rate in unsedated patients who had difficulty with standard air insufflation colonoscopy, resulting in lower pain scores and technical difficulty levels.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Haitao Wang, Haitao Shi, Yan Wang, Na Wang, Youjia Li, Qianting Yang, Ya Li, Chenwei Liu, Ying Zan, Siping Feng, Jiao Xie
Summary: The prevalence of hazardous drug-drug interactions (DDIs) related to oral antineoplastic agents (OAAs) appears to be low in cancer patients. However, physicians and clinical pharmacologists should be aware of the potential hazardous DDIs when prescribing OAAs, especially certain pH-dependent molecular targeted agents and drugs that can prolong QTc interval.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Haitao Shi, Chuying Wang, Jie Wu, Bin Qin, Jiong Jiang, Na Liu, Yahua Song, Yun Qin, Shiyang Ma
Summary: This study retrospectively investigated the outcomes of patients with rectal neuroendocrine tumors (NETs) who underwent underwater endoscopic mucosal resection (UMER) or endoscopic submucosal dissection (ESD), and found that UMER was superior to ESD in terms of operation time, hospitalization time, operation cost, postoperative abdominal pain, and abdominal distention.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Juan Ma, Zhongcao Wei, Qian Wang, Xiaolan Lu, Zhihua Zhou, Ruohan Li, Qiuai Shu, Yixin Liu, Jinhai Wang, Na Liu, Haitao Shi
Summary: This study found that there is an independent association between serum creatinine (SCr) levels and the risk of hepatic steatosis (HS) in a Chinese population. The prevalence of HS significantly increases with higher SCr levels, accompanied by increases in metabolism-related indicators and liver enzymes.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yangfan Hou, Lei Dong, Xiaolan Lu, Haitao Shi, Bing Xu, Wenting Zhong, Lin Ma, Shuhui Wang, Caifeng Yang, Xinyi He, Yidi Zhao, Shenhao Wang
Summary: Changes in intestinal microbiota are associated with the pathogenesis and clinical manifestations of irritable bowel syndrome (IBS).
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Haitao Wang, Haitao Shi, Na Wang, Yan Wang, Li Zhang, Yujie Zhao, Jiao Xie
Summary: This study investigates the incidence and associated factors of potential drug-drug interactions (DDIs) in cardiothoracic intensive care units (CCUs). The results show a high prevalence of potential DDIs in these patients, particularly in units without pharmacist intervention and computerized drug monitoring systems.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jiang Deng, Zhiyi Han, Hailing Tang, Cong Yao, Xiaoling Li, Jingyuan Xu, Mimi Zhou, Xin Xing, Fangxiong Wu, Jianning Li, Xiaolan Lu, Haitao Shi
Summary: This study analyzed the occurrence time, prevalence, and influencing factors of fatty liver disease (FLD) in people undergoing routine screening and evaluation. The results showed that elevated fasting blood glucose (FBG) levels increase the risk of FLD, and age, blood pressure, FBG, body mass index, and triglycerides are independent influencing factors for FLD.
BMC GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Ning Xie, Jiale Xie, Ziwei Wang, Qiuai Shu, Haitao Shi, Jinhai Wang, Na Liu, Feng Xu, Jian Wu
Summary: This study utilized a two-sample Mendelian randomization (MR) analysis to explore the causal effects among calcium, vitamin D (Vit-D), parathyroid hormone (PTH), and irritable bowel syndrome (IBS). The results did not find any causal relationship between serum calcium, Vit-D levels, and the risk of IBS. However, there was an association between genetic predisposition to IBS and decreased levels of PTH.
Article
Medicine, General & Internal
Ning Gao, Jiang Deng, Jinhai Wang, Zhihua Zhou, Cong Yao, Mimi Zhou, Xin Xing, Qian Wang, Xiaolan Lu, Haitao Shi
Summary: The study aimed to analyze the prevalence, associated comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease. The findings revealed that elevated triglycerides levels were common among individuals with non-obese fatty liver disease and proposed triglycerides as a potentially useful indicator for extensive screening of the condition.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yating Sun, Xiaohui Liu, Lianli Wang, Laifu Li, Xiaojing Quan, Haitao Shi, Ting Wang, Lin Mei, Yindi Chen, Yue Zhang, Jingyao Li, Ruiting Meng, Jinhai Wang, Fei Dai
Summary: This study aimed to investigate the therapeutic effect of Losartan on visceral hypersensitivity in rats with irritable bowel syndrome (IBS). The results showed that Losartan reduced pain mediators and inflammatory factors by suppressing enteric glial cell (EGC) activation, thereby alleviating visceral hypersensitivity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Sumei Sha, Haitao Shi, Jie Wu, Ming Zhang, Bin Qin, Longbao Yang, Xin Liu
Summary: Patients with inflammatory bowel disease are at high risk of opportunistic infections, with fungal infections being relatively uncommon. This case report describes the first reported case of ulcerative colitis complicated with Cryptococcus neoformans infection after infliximab treatment. The patient experienced various opportunistic infections, including viruses, fungi, and bacteria. Continued attention to opportunistic infections is crucial for patients with inflammatory bowel disease.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yating Sun, Lianli Wang, Laifu Li, Xiaojing Quan, Haitao Shi, Ting Wang, Lin Mei, Fei Dai
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)