Article
Endocrinology & Metabolism
Mariam Alatrach, Christina Agyin, Carolina Solis-Herrera, Olga Lavryneko, John Adams, Amalia Gastaldelli, Curtis Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo
Summary: This study found that SGLT2 inhibitors have an effect on the increase of endogenous glucose production (EGP) in patients with type 2 diabetes after oral glucose intake. Despite elevated plasma insulin and glucagon, the stimulation of EGP was observed, suggesting that additional factors may be involved.
Article
Biochemistry & Molecular Biology
Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopra
Summary: TMP treatment can improve learning and memory deficits, alleviate hyperglycemia and dyslipidemia, suppress inflammation and apoptosis, and restore cholinergic dysfunction in diabetic rats.
NEUROCHEMICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lin Zhang, Yanjin Hu, Yu An, Qiu Wang, Jia Liu, Guang Wang
Summary: This study used a lipidomic approach to investigate lipid changes in response to treatment with exenatide in T2DM patients. The results showed that exenatide treatment can improve lipid metabolism, especially sphingomyelins, lysophosphatidylcholines, and lysophosphatidylethanolamines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Emilie H. Zobel, Rasmus S. Ripa, Bernt J. von Scholten, Viktor Rotbain Curovic, Andreas Kjaer, Tine W. Hansen, Peter Rossing, Joachim Storling
Summary: Liraglutide has been found to exert anti-inflammatory effects in the peripheral blood mononuclear cells of individuals with type 2 diabetes, with no significant presence of GLP-1 receptor expression. Further research is needed to clarify the indirect effects of liraglutide on PBMC gene expression and establish the anti-inflammatory potential of GLP-1 receptor agonists.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Han Liu, Suohui Zhang, Zequan Zhou, Mengzhen Xing, Yunhua Gao
Summary: In this study, two-layer sustained-release microneedles (TS-MNs) were successfully fabricated for the sustained delivery of exenatide (EXT). The TS-MNs showed good mechanical strength and could penetrate the skin for drug release. Moreover, the TS-MNs retained high drug activity during storage and had high relative bioavailability.
Article
Neurosciences
Ayse Ozkan, Mutay Aydin Aslan, Osman Sinen, Mustafa Munzuroglu, Narin Derin, Hande Parlak, Mehmet Bulbul, Aysel Agar
Summary: This study demonstrates that Adropin enhances spatial memory capacity through Akt/CREB/BDNF signaling pathways, indicating its potential neuroprotective effects.
Article
Endocrinology & Metabolism
Jonatan Bagger, Magnus F. G. Grondahl, Asger Lund, Jens J. Holst, Tina Vilsboll, Filip K. Knop
Summary: The study showed that GLP-1 potentiated the glucagon-suppressive effect of glucose in a dose-dependent manner in healthy individuals and patients with type 2 diabetes. However, patients with type 1 diabetes were insensitive to the glucagonostatic effects of both glucose and GLP-1.
Article
Behavioral Sciences
Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Singh
Summary: This study investigated the effects of heat stress on the hippocampus and spatial memory in rats, revealing that heat exposure can lead to oxidative damage, neuronal apoptosis and spatial memory deficits in the hippocampus. Furthermore, the dysregulation of the BDNF/ERK1/2/CREB axis was found to be associated with cognitive decline under heat stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Chemistry, Medicinal
Yaqin Zhang, Ruofei Chen, Yangyang Jia, Mingwei Chen, Zongwen Shuai
Summary: The study revealed that the GLP-1R agonist exenatide has an effect on coagulation function and platelet aggregation in patients with type 2 diabetes mellitus, which is beneficial for reducing the risk of cardiovascular events.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Linong Ji, Ying Du, Min Xu, Xiangjun Zhou, Zhaohui Mo, Jianhua Ma, Jiarui Li, Yufeng Li, Jingna Lin, Yanjun Wang, Jing Yang, Weihong Song, Hui Jin, Shuguang Pang, Hui Liu, Ping Li, Jie Liu, Minxiu Yao, Wenhui Li, Xiaohong Jiang, Feixia Shen, Houfa Geng, Haifeng Zhou, Jianmin Ran, Minxiang Lei, Yinghong Du, Shandong Ye, Qingbo Guan, Wenshan Lv, Huiwen Tan, Tao Chen, Jinkui Yang, Guijun Qin, Shiyun Li, Lei Chen
Summary: This study demonstrated that PB-119 doses were more effective in controlling blood sugar and well-tolerated compared to placebo over a 12-week period in treatment-naive Chinese patients with type 2 diabetes.
Article
Biochemistry & Molecular Biology
Helia Aghamiri, Majid Jafari-Sabet, Mahmood Hoormand
Summary: CBD can ameliorate topiramate-induced memory loss, involving hippocampal and prefrontal cortical NMDA receptors and the CREB/BDNF signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Yujeong Lee, Hee Ra Park, Joo Yeon Lee, Jaehoon Kim, Seonguk Yang, Chany Lee, Kipom Kim, Hyung Sik Kim, Seung-Cheol Chang, Jaewon Lee
Summary: In a mouse study, low-dose curcumin was found to promote hippocampal neurogenesis and enhance memory retention, suggesting its potential role in preventing age and neurodegenerative disease-related cognitive deficits.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Annemarie B. van der Aart-van Der Beek, Ellen Apperloo, Niels Jongs, Dennis B. Rouw, C. David Sjostrom, Iris Friedli, Lars Johansson, Daniel H. van Raalte, Klaas Hoogenberg, Hiddo J. L. Heerspink
Summary: This study evaluated the effects of dapagliflozin, exenatide, and the combination of dapagliflozin and exenatide on reducing albuminuria in patients with type 2 diabetes and microalbuminuria or macroalbuminuria. The study found that all three treatments could reduce albuminuria, with the combination therapy showing the most significant reduction.
DIABETES OBESITY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Carlos Bendicho-Lavilla, Iria Seoane-Viano, Francisco J. Otero-Espinar, Asteria Luzardo-Alvarez
Summary: This article discusses the challenges of subcutaneous administration of peptide-based therapeutics in diabetes treatment and provides an overview of formulations available for different routes of administration with improved bioavailability and reduced frequency of administration.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Esen Gumuslu, Naci Cine, Merve Ertan, Oguz Mutlu, Ipek Komsuoglu Celikyurt, Guner Ulak
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2018)
Article
Urology & Nephrology
Kerem Teke, Hasan Yilmaz, Ali Kemal Uslubas, Gurler Akpinar, Murat Kasap, Oguz Mutlu, Demir Kursat Yildiz, Nil Guzel, Ozdal Dillioglugil
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2018)
Review
Veterinary Sciences
Ipek Komsuoglu Celikyurt
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2018)
Article
Physiology
Esen Gumuslu, Oguz Mutlu, Sibel Kokturk, Guner Ulak, Fatma Ceyla Eraldemir, Ozan Can Tatar, Alisan Burak Yasar, Pelin Tanyeri, Furuzan Akar, Faruk Erden
CHINESE JOURNAL OF PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Oguz Mutlu, Omer Kurtas, Lenka Kleteckova, Nikola Pinterova, Kristina Holubova, Jiri Horacek, Cyril Hoschl, Ibrahim Uygun, Daniel Bermejo Rodriguez, David Kacer, Franko Muhametaj, Karel Vales
Article
Multidisciplinary Sciences
Mehmet H. Tanyeri, Mehmet E. Buyukokuroglu, Pelin Tanyeri, Oguz Mutlu, Aykut Ozturk, Kubra Yavuz, Rumeysa K. Kaya
Summary: The study found that mirabegron significantly reduces immobility time in the forced swimming test and increases time spent in open arms in the elevated plus maze test, while also improving cognitive impairment induced by scopolamine. Additionally, mirabegron can counteract the impact of scopolamine on swimming speed.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Article
Medicine, Research & Experimental
Oguz Mutlu, Merve Yazici Kara, Pelin Tanyeri, Furuzan Akar, Guner Ulak, Faruk Erden
INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES
(2019)
Article
Medicine, General & Internal
Esen Gumuslu, Oguz Mutlu
JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
E. Gumuslu, O. Mutlu, G. Ulak, F. Akar, F. Erden
EUROPEAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Medicine, Research & Experimental
Mehmet Hanifi Tanyeri, Mehmet Emin Buyukokuroglu, Pelin Tanyeri, Oguz Mutlu, Furuzan Yildiz Akar, Guner Ulak, Bekir Faruk Erden
INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES
(2018)
Article
Medicine, Research & Experimental
Oguz Mutlu, Pelin Tanyeri, Nermin Akdemir, Mehmet Emin Buyukokuroglu, Furuzan Akar, Guner Ulak, Faruk Erden
INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Sevgi Turker-Kaya, Ipek Komsuoglu Celikyurt, Umut Celikyurt, Aygul Kina
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2018)
Review
Public, Environmental & Occupational Health
Ipek Celikyurt, Christoph R. Meier, Michael Kuhne, Beat Schaer
Review
Medicine, General & Internal
Serap Simsek Yavuz, Ipek Komsuoglu Celikyurt
Summary: Monoclonal antibodies appear to be the most effective treatment for COVID-19 based on available evidence, while drugs like lopinavir/ritonavir, hydroxychloroquine, merimepodib, and umifenovir have been found to be ineffective. Further studies are needed to determine the efficacy of other potential treatments for COVID-19.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)