Deep learning to design nuclear-targeting abiotic miniproteins

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

Miniproteins as a Powerful Modality in Drug Development

(2020) Zachary R. Crook et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synthesis of proteins by automated flow chemistry

(2020) N. Hartrampf et al.   SCIENCE

Encodings and models for antimicrobial peptide classification for multi-resistant pathogens

(2019) Sebastian Spänig et al.   BioData Mining

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

(2019) Marie-Eve Beaulieu et al.   Science Translational Medicine

Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

(2019) Colin M. Fadzen et al.   BIOCHEMISTRY

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

(2019) Alex Zhavoronkov et al.   NATURE BIOTECHNOLOGY

Antibody Complementarity Determining Region Design Using High-Capacity Machine Learning

(2019) Ge Liu et al.   BIOINFORMATICS

Predicting HLA class II antigen presentation through integrated deep learning

(2019) Binbin Chen et al.   NATURE BIOTECHNOLOGY

Machine learning-enabled discovery and design of membrane-active peptides

(2018) Ernest Y. Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Machine-Learning-Based Prediction of Cell-Penetrating Peptides and Their Uptake Efficiency with Improved Accuracy

(2018) Balachandran Manavalan et al.   JOURNAL OF PROTEOME RESEARCH

Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

(2018) Justin M. Wolfe et al.   ACS Central Science

KELM-CPPpred: Kernel Extreme Learning Machine Based Prediction Model for Cell-Penetrating Peptides

(2018) Poonam Pandey et al.   JOURNAL OF PROTEOME RESEARCH

Targeted Intracellular Delivery of Antibodies: The State of the Art

(2018) Tatiana A. Slastnikova et al.   Frontiers in Pharmacology

Empirical comparison and analysis of web-based cell-penetrating peptide prediction tools

(2018) Ran Su et al.   BRIEFINGS IN BIOINFORMATICS

A fully automated flow-based approach for accelerated peptide synthesis

(2017) Alexander J Mijalis et al.   Nature Chemical Biology

Therapeutic Antibodies against Intracellular Tumor Antigens

(2017) Iva Trenevska et al.   Frontiers in Immunology

Cell-penetrating peptides with intracellular organelle targeting

(2016) Carmine Pasquale Cerrato et al.   Expert Opinion on Drug Delivery

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Quantitative fluorescence spectroscopy and flow cytometry analyses of cell-penetrating peptides internalization pathways: optimization, pitfalls, comparison with mass spectrometry quantification

(2016) Françoise Illien et al.   Scientific Reports

Delivery of therapeutic oligonucleotides with cell penetrating peptides

(2015) Prisca Boisguérin et al.   ADVANCED DRUG DELIVERY REVIEWS

CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides

(2015) Piyush Agrawal et al.   NUCLEIC ACIDS RESEARCH

Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability

(2014) Nicole Nischan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Promises and Pitfalls of Intracellular Delivery of Proteins

(2014) Ailing Fu et al.   BIOCONJUGATE CHEMISTRY

Eteplirsen for the treatment of Duchenne muscular dystrophy

(2013) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

(2012) Corinne Betts et al.   Molecular Therapy-Nucleic Acids

Prediction of Cell Penetrating Peptides by Support Vector Machines

(2011) William S. Sanders et al.   PLoS Computational Biology

Prediction of Cell-Penetrating Peptides Using Artificial Neural Networks

(2010) Dimitar A. Dobchev et al.   Current Computer-Aided Drug Design

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Gene Knockdowns in Adult Animals: PPMOs and Vivo-Morpholinos

(2009) Jon Moulton et al.   MOLECULES

Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice

(2008) Natee Jearawiriyapaisarn et al.   MOLECULAR THERAPY