Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

Structural and functional characterization of the Spo11 core complex

(2021) Corentin Claeys Bouuaert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA-driven condensation assembles the meiotic DNA break machinery

(2021) Corentin Claeys Bouuaert et al.   NATURE

Spo11 generates gaps through concerted cuts at sites of topological stress

(2021) Silvia Prieler et al.   NATURE

PCNA activates the MutLγ endonuclease to promote meiotic crossing over

(2020) Dhananjaya S. Kulkarni et al.   NATURE

Regulation of the MLH1–MLH3 endonuclease in meiosis

(2020) Elda Cannavo et al.   NATURE

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

(2019) William H. Gittens et al.   Nature Communications

Nucleosomes and DNA methylation shape meiotic DSB frequency inArabidopsis thalianatransposons and gene regulatory regions

(2018) Kyuha Choi et al.   GENOME RESEARCH

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

(2018) Marie-Claude Marsolier-Kergoat et al.   MOLECULAR CELL

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair

(2016) Julian Lange et al.   CELL

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1

(2016) Neeman Mohibullah et al.   GENOME RESEARCH

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

(2015) Valerie Garcia et al.   NATURE

Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome

(2014) Kyle R. Fowler et al.   GENOME RESEARCH

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

(2013) Jesús A. Carballo et al.   PLoS Genetics

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

DrosophilaATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair

(2011) Eric F. Joyce et al.   JOURNAL OF CELL BIOLOGY

ATM controls meiotic double-strand-break formation

(2011) Julian Lange et al.   NATURE

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids

(2011) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis of Heteroduplex DNA in Mismatch Repair–Deficient Yeast Cells Reveals Novel Properties of Meiotic Recombination Pathways

(2011) Emmanuelle Martini et al.   PLoS Genetics

Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice

(2010) R. Kumar et al.   GENES & DEVELOPMENT

Rec8 Guides Canonical Spo11 Distribution along Yeast Meiotic Chromosomes

(2009) Kazuto Kugou et al.   MOLECULAR BIOLOGY OF THE CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE