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The next generation therapy for lung cancer: taking medicine by inhalation

期刊

NANOTECHNOLOGY
卷 32, 期 39, 页码 -

出版社

IOP Publishing Ltd
DOI: 10.1088/1361-6528/ac0e68

关键词

lung cancer; pulmonary delivery; painless administration; inhalation

资金

  1. National Nature Science Foundation of China [31971318, 21876205]
  2. Key-Area Research and Development Program of Guangdong Province [2020B0101020001]
  3. Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
  4. Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS [NSKF202015]

向作者/读者索取更多资源

Inhalation administration for treating respiratory diseases, particularly lung cancer, offers advantages of targeted treatment, high efficiency, and improved drug delivery. Recent research has focused on different forms of inhalation administration and strategies to overcome obstacles, providing new insights for improving lung cancer treatment methods.
The inhalation administration method which has been applied to treat respiratory diseases has the characteristics of painlessness high efficiency and non-invasiveness, and the drug can also be targeted at the organ level first to reduce the loss of drug during circulation. Therefore, delivering medicine by inhalation administration has brought a new turnaround for lung cancer treatment. Herein from the perspective of combining traditional drug delivery design strategies with new drug delivery methods how to improve lung targeting efficiency and treatment efficacy is discussed. We also discuss the comparative advantages of inhaled drug delivery and traditional administration in the treatment of lung cancer such as intravenous injection. And the researches are divided into different forms of inhalation administration studied in the treatment of lung cancer in recent years, such as single-component loaded and multi-component loaded systems and their advantages. Finally, the obstacles of the application of carrier materials for inhalation administration and the prospects for improvement of lung cancer treatment methods are presented.

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