Micro- and nanoscale biophysical cues for cardiovascular disease therapy

Construction of vascular graft with circumferentially oriented microchannels for improving artery regeneration

(2020) Pingli Wu et al.   BIOMATERIALS

Predicting gene expression using morphological cell responses to nanotopography

(2020) Marie F. A. Cutiongco et al.   Nature Communications

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

(2020) Matthew J. Vassey et al.   Advanced Science

Macrophages of diverse phenotypes drive vascularization of engineered tissues

(2020) P. L. Graney et al.   Science Advances

4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction

(2020) Haitao Cui et al.   Science Advances

Delivery of Human Stromal Vascular Fraction Cells on Nanofibrillar Scaffolds for Treatment of Peripheral Arterial Disease

(2020) Caroline Hu et al.   Frontiers in Bioengineering and Biotechnology

Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing

(2020) Aleena Mary Cherian et al.   ACS Omega

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

(2019) Meredith A. Redd et al.   Nature Communications

Temporal Impact of Substrate Anisotropy on Differentiating Cardiomyocyte Alignment and Functionality

(2019) Alicia CB Allen et al.   TISSUE ENGINEERING PART A

Stiffness of Aligned Fibers Regulates the Phenotypic Expression of Vascular Smooth Muscle Cells

(2019) Bingcheng Yi et al.   ACS Applied Materials & Interfaces

Hang on tight: reprogramming the cell with microstructural cues

(2019) Long V. Le et al.   BIOMEDICAL MICRODEVICES

Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis

(2019) Gabriel Romero Liguori et al.   Stem Cells International

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

(2019) Farid Alisafaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Restoration of Myocardial Conduction With Carbon Nanotube Fibers

(2019) Mark D. McCauley et al.   Circulation-Arrhythmia and Electrophysiology

Vascular Endothelial Cell Biology: An Update

(2019) Krüger-Genge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascularization of Engineered Spatially Patterned Myocardial Tissue Derived From Human Pluripotent Stem Cells in vivo

(2019) Maureen Wanjare et al.   Frontiers in Bioengineering and Biotechnology

Modulation of Foreign Body Reaction against PDMS Implant by Grafting Topographically Different Poly(acrylic acid) Micropatterns

(2019) Jae Sang Lee et al.   MACROMOLECULAR BIOSCIENCE

Anti-oxidant activity reinforced reduced graphene oxide/alginate microgels: Mesenchymal stem cell encapsulation and regeneration of infarcted hearts

(2019) Goeun Choe et al.   BIOMATERIALS

Ta ion implanted nanoridge-platform for enhanced vascular responses

(2019) Tae-Sik Jang et al.   BIOMATERIALS

Microengineered biosynthesized cellulose as anti-fibrotic in vivo protection for cardiac implantable electronic devices

(2019) Francesco Robotti et al.   BIOMATERIALS

Mechanophysical Cues in Extracellular Matrix Regulation of Cell Behavior

(2019) Tuntun Wang et al.   CHEMBIOCHEM

Constrained Adherable Area of Nanotopographic Surfaces Promotes Cell Migration through the Regulation of Focal Adhesion via Focal Adhesion Kinase/Rac1 Activation

(2018) Jiwon Lim et al.   ACS Applied Materials & Interfaces

Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization

(2018) Mahdis Shayan et al.   Acta Biomaterialia

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction

(2018) Michaella Kapnisi et al.   ADVANCED FUNCTIONAL MATERIALS

Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction

(2018) Long V. Le et al.   BIOMATERIALS

Functional differences between healthy and diabetic endothelial cells on topographical cues

(2018) Marie F.A. Cutiongco et al.   BIOMATERIALS

Titania nanopores with dual micro-/nano-topography for selective cellular bioactivity

(2018) Karan Gulati et al.   Materials Science & Engineering C-Materials for Biological Applications

A micron-scale surface topography design reducing cell adhesion to implanted materials

(2018) Francesco Robotti et al.   Scientific Reports

Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering

(2018) Jonathan H. Tsui et al.   Journal of Materials Chemistry B

Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation

(2018) Miguel Castilho et al.   ADVANCED FUNCTIONAL MATERIALS

Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy

(2018) Bin Xu et al.   BIOMATERIALS

Substrate topography interacts with substrate stiffness and culture time to regulate mechanical properties and smooth muscle differentiation of mesenchymal stem cells

(2018) Azim Parandakh et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Spatial confinement downsizes the inflammatory response of macrophages

(2018) Nikhil Jain et al.   NATURE MATERIALS

Surface Patterning and Innate Physicochemical Attributes of Silk Films Concomitantly Govern Vascular Cell Dynamics

(2018) Prerak Gupta et al.   ACS Biomaterials-Science & Engineering

Mechanical regulation of cardiac fibroblast profibrotic phenotypes

(2017) Kate M. Herum et al.   MOLECULAR BIOLOGY OF THE CELL

Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression

(2017) Yejun Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Bioinspired onion epithelium-like structure promotes the maturation of cardiomyocytes derived from human pluripotent stem cells

(2017) Cong Xu et al.   Biomaterials Science

Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells

(2017) Maureen Wanjare et al.   Biomaterials Science

Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium

(2017) Junjun Li et al.   Stem Cell Reports

Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behavior Provides Insights beyond Predefined Polarization States

(2017) Sonali Singh et al.   ACS Biomaterials-Science & Engineering

Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behavior Provides Insights beyond Predefined Polarization States

(2017) Sonali Singh et al.   ACS Biomaterials Science & Engineering

Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells

(2016) Daniel Carson et al.   ACS Applied Materials & Interfaces

Titanium surface characteristics, including topography and wettability, alter macrophage activation

(2016) Kelly M. Hotchkiss et al.   Acta Biomaterialia

A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity

(2016) Angie M. Y. Shum et al.   ADVANCED MATERIALS

Planar and tubular patterning of micro and nano-topographies on poly(vinyl alcohol) hydrogel for improved endothelial cell responses

(2016) Marie F.A. Cutiongco et al.   BIOMATERIALS

Biomimetic cardiovascular stents for in vivo re-endothelialization

(2016) Chunyong Liang et al.   BIOMATERIALS

Spatiotemporal control of cardiac anisotropy using dynamic nanotopographic cues

(2016) Paulos Y. Mengsteab et al.   BIOMATERIALS

Long-Term Outcome of Administration of c-kitPOSCardiac Progenitor Cells After Acute Myocardial InfarctionNovelty and Significance

(2016) Xian-Liang Tang et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Topographically and elastically micropatterned PEG-based hydrogels to control cell adhesion and migration

(2016) Gonzalo de Vicente et al.   EUROPEAN POLYMER JOURNAL

Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion

(2016) Haisle Moon et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Responses of endothelial cells, smooth muscle cells, and platelets dependent on the surface topography of polytetrafluoroethylene

(2016) Sujan Lamichhane et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Novel PGS/PCL electrospun fiber mats with patterned topographical features for cardiac patch applications

(2016) M. Tallawi et al.   Materials Science & Engineering C-Materials for Biological Applications

Highly aligned core–shell structured nanofibers for promoting phenotypic expression of vSMCs for vascular regeneration

(2016) Huihua Yuan et al.   Nanoscale

Biomechanical Characterization of Cardiomyocyte Using PDMS Pillar with Microgrooves

(2016) Nomin-Erdene Oyunbaatar et al.   SENSORS

Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?

(2016) Maribella Domenech et al.   TISSUE ENGINEERING PART B-REVIEWS

Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers

(2016) Yaohua Gao et al.   Advanced Healthcare Materials

Cell Migration According to Shape of Graphene Oxide Micropatterns

(2016) Sung Kim et al.   Micromachines

Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment

(2016) Dario Buccheri et al.   Journal of Thoracic Disease

Nitinol-Based Nanotubular Arrays with Controlled Diameters Upregulate Human Vascular Cell ECM Production

(2016) Phin P. Lee et al.   ACS Biomaterials-Science & Engineering

Nitinol-Based Nanotubular Arrays with Controlled Diameters Upregulate Human Vascular Cell ECM Production

(2016) Phin P. Lee et al.   ACS Biomaterials Science & Engineering

Combined Effects of Substrate Topography and Stiffness on Endothelial Cytokine and Chemokine Secretion

(2015) Hyeona Jeon et al.   ACS Applied Materials & Interfaces

Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype

(2015) Thuy U. Luu et al.   ACS Applied Materials & Interfaces

Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis

(2015) Karina H. Nakayama et al.   ACS Nano

Micro- and nano-topography to enhance proliferation and sustain functional markers of donor-derived primary human corneal endothelial cells

(2015) Rizwan Muhammad et al.   Acta Biomaterialia

Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants

(2015) Hicham Majd et al.   BIOMATERIALS

Development and functional evaluation of biomimetic silicone surfaces with hierarchical micro/nano-topographical features demonstrates favourable in vitro foreign body response of breast-derived fibroblasts

(2015) Daniel J.T. Kyle et al.   BIOMATERIALS

Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction

(2015) James R. Peña et al.   BIOMATERIALS

Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues

(2015) Constant Morez et al.   BIOMATERIALS

Circumferentially aligned fibers guided functional neoartery regeneration in vivo

(2015) Meifeng Zhu et al.   BIOMATERIALS

Evaluation of remodeling process in small-diameter cell-free tissue-engineered arterial graft

(2015) Shuhei Tara et al.   JOURNAL OF VASCULAR SURGERY

Real time macrophage migration analysis and associated pro-inflammatory cytokine release on transparent carbon nanotube/polymer composite nano-film

(2015) Dongwoo Khang   NANOTECHNOLOGY

The Tissue-Engineered Vascular Graft—Past, Present, and Future

(2015) Samand Pashneh-Tala et al.   TISSUE ENGINEERING PART B-REVIEWS

Patterning Vascular NetworksIn Vivofor Tissue Engineering Applications

(2015) Ritika R. Chaturvedi et al.   TISSUE ENGINEERING PART C-METHODS

Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials

(2015) Zeeshan Sheikh et al.   Materials

Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

(2015) Yan Zhang et al.   Advanced Healthcare Materials

Atherosclerosis and the role of immune cells

(2015) Fulya Ilhan   World Journal of Clinical Cases

Directing Vascular Cell Selectivity and Hemocompatibility on Patterned Platforms Featuring Variable Topographic Geometry and Size

(2014) Yonghui Ding et al.   ACS Applied Materials & Interfaces

Well-organized neointima of large-pore poly(l-lactic acid) vascular graft coated with poly(l-lactic-co-ε-caprolactone) prevents calcific deposition compared to small-pore electrospun poly(l-lactic acid) graft in a mouse aortic implantation model

(2014) Shuhei Tara et al.   ATHEROSCLEROSIS

Differential Response of Endothelial and Endothelial Colony Forming Cells on Electrospun Scaffolds with Distinct Microfiber Diameters

(2014) Emanuela S. Fioretta et al.   BIOMACROMOLECULES

The influence of surface micro-structure on endothelialization under supraphysiological wall shear stress

(2014) Francesco Robotti et al.   BIOMATERIALS

Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes

(2014) Max R. Salick et al.   BIOMATERIALS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction

(2014) James R. Pinney et al.   BIOMATERIALS

Combining cell sheet technology and electrospun scaffolding for engineered tubular, aligned, and contractile blood vessels

(2014) Shahrzad Rayatpisheh et al.   BIOMATERIALS

Physical and mechanical regulation of macrophage phenotype and function

(2014) Frances Y. McWhorter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Influence of micropattern width on differentiation of human mesenchymal stem cells to vascular smooth muscle cells

(2014) Tomoko Nakamoto et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Proteins, platelets, and blood coagulation at biomaterial interfaces

(2014) Li-Chong Xu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Combined Nano- and Micro-Scale Topographic Cues for Engineered Vascular Constructs by Electrospinning and Imprinted Micro-Patterns

(2014) Maria Moffa et al.   Small

Synergistic Effects of Matrix Nanotopography and Stiffness on Vascular Smooth Muscle Cell Function

(2014) Somali Chaterji et al.   TISSUE ENGINEERING PART A

Fabrication of poly(ethylene glycol): gelatin methacrylate composite nanostructures with tunable stiffness and degradation for vascular tissue engineering

(2014) Peter Kim et al.   Biofabrication

Controlling the structural and functional anisotropy of engineered cardiac tissues

(2014) Weining Bian et al.   Biofabrication

A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair

(2014) Yi-Dong Lin et al.   Biomaterials Science

Three-dimensional filamentous human diseased cardiac tissue model

(2013) Zhen Ma et al.   BIOMATERIALS

Circumferential alignment of vascular smooth muscle cells in a circular microfluidic channel

(2013) Jong Seob Choi et al.   BIOMATERIALS

Nerve regeneration and elastin formation within poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model

(2013) Robert A. Allen et al.   BIOMATERIALS

Engineering cell alignment in vitro

(2013) Yuhui Li et al.   BIOTECHNOLOGY ADVANCES

The influence of electrospun scaffold topography on endothelial cell morphology, alignment, and adhesion in response to fluid flow

(2013) Bryce M. Whited et al.   BIOTECHNOLOGY AND BIOENGINEERING

Complications after cardiac implantable electronic device implantations: an analysis of a complete, nationwide cohort in Denmark

(2013) R. E. Kirkfeldt et al.   EUROPEAN HEART JOURNAL

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

(2013) Scott D. Lundy et al.   STEM CELLS AND DEVELOPMENT

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes

(2012) Christine L. Mummery et al.   CIRCULATION RESEARCH

Structural and biomechanical characterizations of porcine myocardial extracellular matrix

(2012) Bo Wang et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Hydrogel Substrate Stiffness and Topography Interact to Induce Contact Guidance in Cardiac Fibroblasts

(2012) Shahed Al-Haque et al.   MACROMOLECULAR BIOSCIENCE

Signaling networks regulating leukocyte podosome dynamics and function

(2011) Athanassios Dovas et al.   CELLULAR SIGNALLING

Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice

(2010) M. Kobara et al.   CARDIOVASCULAR RESEARCH

Complication Rates Associated With Pacemaker or Implantable Cardioverter-Defibrillator Generator Replacements and Upgrade Procedures

(2010) Jeanne E. Poole et al.   CIRCULATION

Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

(2010) Geoffrey G. Hesketh et al.   CIRCULATION RESEARCH

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

(2009) Christopher J. Bettinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of apoptosis in cardiovascular disease

(2009) Youngil Lee et al.   APOPTOSIS

Physiologic compliance in engineered small-diameter arterial constructs based on an elastomeric substrate

(2009) Peter M. Crapo et al.   BIOMATERIALS

Electrophysiological Challenges of Cell-Based Myocardial Repair

(2009) Huei-Sheng Vincent Chen et al.   CIRCULATION

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Characterization of Endothelial Basement Membrane Nanotopography in Rhesus Macaque as a Guide for Vessel Tissue Engineering

(2009) Sara J. Liliensiek et al.   TISSUE ENGINEERING PART A

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Delayed Arterial Healing and Increased Late Stent Thrombosis at Culprit Sites After Drug-Eluting Stent Placement for Acute Myocardial Infarction Patients

(2008) Gaku Nakazawa et al.   CIRCULATION

Pacemaker and ICD leads: Strategies for long-term management

(2008) P. Peter Borek et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

Enhancing Efficacy of Stem Cell Transplantation to the Heart with a PEGylated Fibrin Biomatrix

(2008) Ge Zhang et al.   TISSUE ENGINEERING PART A

Vitronectin is a critical protein adhesion substrate for IL‐4‐induced foreign body giant cell formation

(2007) Amy K. McNally et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A