Article
Pharmacology & Pharmacy
Wenpan Li, Yanhao Jiang, Jianqin Lu
Summary: Tumor immunotherapy, specifically tumor immunogenic cell death (ICD), has shown great potential for cancer therapy. Nanoparticles, such as liposomes, nanostructured lipid carriers, and inorganic nanoparticles, have been widely studied as vehicles for delivering ICD inducers. This review summarizes the strategies of different nanoparticles for ICD-induced cancer immunotherapy and discusses their advantages, disadvantages, and potential solutions. It aims to provide insights into the design of effective nanoparticulate systems for the therapeutic delivery of ICD inducers, ultimately promoting the development of ICD-mediated cancer immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Hang Liu, Zhaohua Miao, Zhengbao Zha
Summary: Nanoparticle-based disease diagnosis and therapy, especially using membrane coating nanotechnology, have shown great potential in enhancing disease targeting and specificity. This review summarizes the latest development of biomimetic nanoparticles for immunotherapy in treating immune-related diseases.
CHINESE CHEMICAL LETTERS
(2022)
Review
Nanoscience & Nanotechnology
Jing Qi, Feiyang Jin, Xiaoling Xu, Yongzhong Du
Summary: Cancer immunotherapy aims to enhance immune responses against cancer, with the combination of ICD inducers and immune checkpoint inhibitors showing significant antitumor effects. Nanoparticles can modulate systemic biodistribution and facilitate the clinical translation of immunotherapies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Liwen Fu, Xiaojun Zhou, Chuanglong He
Summary: Immunotherapy has shown a promising direction for cancer treatment by regulating the anti-cancer immune system through immunogenic cancer cell death (ICD). Polymer nanoparticles play a critical role in delivering antigens or immune inducers for ICD-based immunotherapy with their controllable size and excellent biocompatibility.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Qingwen Liu, Yongmao Hu, Peng Zheng, Ying Yang, Yuting Fu, Ying Yang, Biao Duan, Mengzhen Wang, Duo Li, Weiran Li, Jinrong He, Xiao Zheng, Qiong Long, Yanbing Ma
Summary: This study developed a strategy of membrane-based biomimetic nanovaccine, using immunogenic cell death (ICD) mechanism and nanoscale delivery of tumor antigens, to stimulate anti-tumor immunity. The nanovaccine significantly enhanced the migration, antigen uptake, and maturation of dendritic cells in vitro, and improved antigen lysosome escape and accumulation in lymph nodes in vivo. In a TC-1 tumor model, the nanovaccine elicited a dramatical antitumor immune response.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Immunology
Yichen Guo, Rong Ma, Mengzhe Zhang, Yongjian Cao, Zhenzhong Zhang, Weijing Yang
Summary: This review summarizes the latest studies on nanotechnology-mediated immunogenic cell death for effective cancer immunotherapy and highlights the challenges.
Review
Chemistry, Physical
Mengyao Yang, Cheng Zhang, Rui Wang, Xiaofeng Wu, Haidong Li, Juyoung Yoon
Summary: Cancer immunotherapy is a revolutionary treatment that not only eliminates tumors but also prevents metastases and recurrent tumors. However, the effectiveness of immunotherapy induced by immunogenic cell death (ICD) is limited due to low accumulation of ICD inducers in tumors and damage to normal tissues. Smart nanomaterials offer a solution to these challenges with their targeted delivery, stability, bioavailability, on-demand release, and biocompatibility. This article summarizes the design of targeted nanomaterials, various ICD inducers, and the applications of nanomaterials responsive to different stimuli, providing insights for designing novel smart nanomaterials for ICD-induced immunotherapy.
Article
Chemistry, Multidisciplinary
Xiang Xiong, Jingya Zhao, Rui Su, Chunping Liu, Xing Guo, Shaobing Zhou
Summary: The study introduces a novel strategy for enhanced tumor immunotherapy by combining different carriers to achieve targeted delivery to tumors and activation of immune response, resulting in improved efficacy in tumor therapy.
Article
Pharmacology & Pharmacy
Zhenzhen Chen, Qian Zhang, Qinbiao Huang, Zhihong Liu, Lingjun Zeng, Lingna Zhang, Xu Chen, Hongtao Song, Jialiang Zhang
Summary: This study presents a new strategy for inducing immunogenic cell death (ICD) using photothermal MnO2 nanoparticles in tumor immunotherapy. By loading the ICD inducer DOX onto the MnO2 nanoparticles, high photothermal conversion efficiency, efficient tumor targeting, TME-responsive release of DOX, and modulation of the hypoxic TME were achieved. The combination of chemo-photothermal therapy-induced ICD and improvement of the immunosuppressive TME showed a significant synergistic therapeutic effect in a mouse model of triple-negative breast carcinoma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Yannan Yang, Zhengying Gu, Jie Tang, Min Zhang, Yang Yang, Hao Song, Chengzhong Yu
Summary: The study challenges the traditional view of MnO2 nanoparticles as merely assisting in cancer immunotherapy, revealing their intrinsic immunomodulatory property in inducing immunogenic cell death. This unique property is exploited for a new cancer starvation-immunotherapy approach, showing promising efficacy in suppressing local and distant tumors.
Review
Oncology
Ting Wang, Wangrui Peng, Meng Du, Zhiyi Chen
Summary: Immunotherapy is a promising treatment for cancer, but its application is limited due to the suppression of tumor microenvironment and immune-related adverse events. Sonodynamic therapy (SDT) has been shown to effectively activate antitumor immunity and kill tumor cells. Various SDT therapies alone or in combination with other treatments have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper provides an overview of the research progress in SDT and nanotechnology, discusses the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and SDT-based immunotherapy for multimodal immunotherapy. The prospects and challenges of SDT-based therapies in cancer immunotherapy are also discussed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiang Li, Zhaogang Teng, Jun Tao, Wenhui Shi, Guangwen Yang, Yu Zhang, Xiaodan Su, Lin Chen, Weijun Xiu, Lihui Yuwen, Heng Dong, Yongbin Mou
Summary: The elasticity-dependent effect of the nanovaccine on dendritic cell-mediated immune responses is studied. The prepared soft mesoporous organosilica-based nanovaccine (SMONV) shows enhanced internalization by dendritic cells and induces effective antigen delivery, leading to immune response activation. Moreover, SMONV also enhances lymphatic drainage of antigens, stimulating robust humoral and cellular immunity.
Article
Pharmacology & Pharmacy
Minghui Li, Mengmeng Qin, Ge Song, Hailiang Deng, Dakuan Wang, Xueqing Wang, Wenbing Dai, Bing He, Hua Zhang, Qiang Zhang
Summary: This study proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens, with calcium pyrophosphate nanogranules serving as both delivery vehicles and adjuvants. The biomimetic vaccine demonstrated strong T-cell response, excellent tumor therapy and prophylactic effects, as well as nice biocompatibility, showing potential for further design and application of antitumor vaccines.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: Increasing extracellular ATP can amplify immunogenic cell death cascade for cancer immunotherapy, but its intra-tumoral delivery is challenging due to the enzyme environment and tumor immunosuppressive microenvironment. To overcome these limitations, researchers have developed a tumor-permeated ATP-based immunogenic cell death amplifier.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Multidisciplinary
BeiBei Chen, KangLi Guo, HaoRan Wang, Fu-Jian Xu, JuLin Wang, NaNa Zhao
Summary: This study demonstrates the use of Janus nanoparticles for enhanced cancer immunotherapy by optimizing their composition and morphology. The findings show that these nanoparticles can induce immunogenic cell death of tumor cells and activate antitumor immune responses through a combination therapy approach involving starvation therapy, chemodynamic therapy, and immunoadjuvant properties.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)