Article
Genetics & Heredity
Lixia Pu, Zhongli Liu, Aijiang Guo, Bin Wu, Guo-hua Liu, Shaohua Zhang, Xiaola Guo, Xiaolu Li, Jianbo Jian, Xuepeng Cai, Shuai Wang
Summary: A high-quality genome of Taenia pisiformis was assembled in this study, revealing its genetic features and evolutionary relationship with other parasites. The findings provide valuable resources for comparative genomics and further applications in parasitology.
Article
Genetics & Heredity
Lixia Pu, Zhongli Liu, Aijiang Guo, Bin Wu, Guo-hua Liu, Shaohua Zhang, Xiaola Guo, Xiaolu Li, Jianbo Jian, Xuepeng Cai, Shuai Wang
Summary: The high-quality genome of Taenia pisiformis provides a resource for comparative genomics and further applications in general parasitology. Comparative genomic analyses revealed adaptive features of strong positive selection signals from carbohydrate/lipid metabolism and body surface integrity, as well as expanded gene families related to metabolism of amino acids and lipids.
Article
Microbiology
Malgorzata Samorek-Pierog, Jacek Karamon, Adam Brzana, Ewa Bilska-Zajac, Jolanta Zdybel, Tomasz Cencek
Summary: This study aimed to molecularly characterize Taenia pisiformis cysts isolated from rabbits and confirmed the first molecular confirmation of T. pisiformis metacestodes infection in rabbits in Poland. Phylogenetic analysis identified a new haplotype, providing valuable data for species description.
Article
Parasitology
Grazia Biosa, Piero Bonelli, Salvatore Pisanu, Stefania Ghisaura, Cinzia Santucciu, Angela Peruzzu, Giovanni Garippa, Sergio Uzzau, Giovanna Masala, Daniela Pagnozzi
Summary: The proteome of hydatid cyst fluids of Echinococcus granulosus and other ovine parasites were analyzed, and potential diagnostic biomarkers for cystic echinococcosis (CE) were identified, which can predict CE in sheep and differentiate between different types of parasites.
Article
Veterinary Sciences
Susana Remesar, Sabrina Castro-Scholten, Debora Jimenez-Martin, Leonor Camacho-Sillero, Patrocinio Morrondo, Carlos Rouco, Felix Gomez-Guillamon, David Cano-Terriza, Ignacio Garcia-Bocanegra
Summary: A study conducted epidemiological surveillance of cysticercosis in wild rabbits in Spanish Mediterranean ecosystems, revealing a certain prevalence of Cysticercus pisiformis in these animals, particularly during the period of 2012-2015. Furthermore, infected animals were found in 41 out of 164 hunting estates, but no significant spatial clusters of high prevalence were identified.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Biology
Chuan-Yang Fu, Hong-Yu Chen, Cheng-Yung Lin, Shiang-Jiuun Chen, Jin-Chuan Sheu, Huai-Jen Tsai
Summary: Understanding the molecular interaction between ligand and receptor is crucial for regenerative drug development. This study identifies that extracellular Pgk1 interacts with neural membrane Enolase-2, promoting neurite outgrowth. By reducing the P38/Limk1/Cofilin signaling pathway, Pgk1-Enolase-2 interaction enhances neuronal growth. This finding can aid in the screening of potential small molecule drugs for promoting motor nerve regeneration.
COMMUNICATIONS BIOLOGY
(2023)
Article
Parasitology
Shaohua Zhang, Bingtian Jin, Weijia Liang, Aijiang Guo, Xuenong Luo, Lixia Pu, Xiaoqing Chen, Xuepeng Cai, Shuai Wang
Summary: In this study, a new member of the SUMO protein family, TpSUMO, was identified from Taenia pisiformis and found to play a crucial role in regulating worm growth and development.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Microbiology
Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Diana Elizabeth Hernandez-Ceron, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Cesar Raul Gonzalez-Bonilla, Rosa del Carmen Rocha-Gracia, Alejandro Carabarin-Lima
Summary: Haemophilus influenzae causes invasive pediatric diseases, while non-typeable H. influenzae strains are associated with localized infections. Enolase in these bacteria acts as a receptor for plasminogen, promoting tissue invasion. The interaction between NTHi enolase and human plasminogen may be a mechanism used by H. influenzae for host cell adhesion and invasion.
Article
Biotechnology & Applied Microbiology
Liqun Wang, Tingli Liu, Guiting Pu, Guoliang Chen, Hong Li, Shaohua Zhang, Yanping Li, Xuenong Luo
Summary: Research on the mechanism of how T. pisiformis cysticercus manipulates the host immune system is important due to frequent infection and economic losses in rabbits.
Article
Microbiology
Liqun Wang, Tingli Liu, Guoliang Chen, Yanping Li, Shaohua Zhang, Li Mao, Panhong Liang, Majid Fasihi Harandi, Taoshan Li, Xuenong Luo
Summary: The study reveals that miR-let-7-5p released by Taenia pisiformis cysticercus plays a critical role in activating M2 macrophages, inducing M2 macrophage polarization by targeting C/EBP delta.
Article
Immunology
Qingyun Xie, Huixuan Xing, Xiaoyun Wen, Beibei Liu, Yanna Wei, Yanfei Yu, Xing Xie, Daesub Song, Guoqing Shao, Qiyan Xiong, Zhixin Feng
Summary: Mycoplasma hyopneumoniae enolase can stably bind and activate plasminogen, facilitating its adhesion and invasion. Both the C-terminal and N-terminal regions of enolase play important roles in this process. Additionally, enolase can competitively inhibit M. hyopneumoniae adherence to host cells.
MICROBIAL PATHOGENESIS
(2023)
Article
Parasitology
Shyun Chou, Masato Ozawa, Katsuki Matsubara, Kenichi Tamukai, Toshihiro Tokiwa
Summary: This study reports a case of subcutaneous proliferative cysticercosis in a pet steppe lemming, where numerous metacestodes identified as the larval stage of Taenia crassiceps were collected from the subcutaneous cystic lesion of the left medial thigh. Despite four surgical removals coupled with anthelmintic treatment, recurrence occurred. This is the third case of the parasite detected from imported animals in Japan and raises public health concerns.
PARASITOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Dorota Satala, Aneta Bednarek, Andrzej Kozik, Maria Rapala-Kozik, Justyna Karkowska-Kuleta
Summary: The development of infections caused by pathogenic bacteria is closely related to the specific properties of the bacterial cell surface and extracellular hydrolytic activity, as well as the hijacking of host proteolytic cascades by pathogens. This review focuses on the mechanisms of bacterial impact on host plasminogen, including cell surface exposition of various proteins, binding of this host (pro)enzyme and its activators or inhibitors, and the exploitation of fibrinolytic system activation tactics by different bacterial species. The involvement of bacterial factors in modulating plasminogen activation and fibrinolysis during periodontitis is also described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Elisa Barroeta-Echegaray, Rocio Fonseca-Linan, Raul Arguello-Garcia, Rafael Rodriguez-Munoz, Rosa Maria Bermudez-Cruz, Porfirio Nava, M. Guadalupe Ortega-Pierres
Summary: Enolase produced by G. duodenalis initiates proteolysis of extracellular matrix components through plasminogen activation, affecting interactions between trophozoites and epithelial cells. These findings suggest that Giardia enolase acts as a virulence factor by inducing necroptotic-like cell processes mediated by TNF-alpha and AIF activities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Yufei Zhang, Amira Abdu, Timothy Wu, Maria J. Forzan, Kimberly Hammer, Manigandan Lejeune
Summary: This report documents the occurrence of Taenia crassiceps metacestodes in a muskrat and a domestic dog in the northeastern United States. The finding highlights the importance of increased awareness, surveillance, and timely intervention for the diagnosis and prevention of this disease.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.