Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

(2015) Michele Simbolo et al.   Oncotarget

Activity and safety of RAD001 (everolimus) in patients affected by biliary tract cancer progressing after prior chemotherapy: a phase II ITMO study

(2014) R. Buzzoni et al.   ANNALS OF ONCOLOGY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phase I Clinical Trial of the Mammalian Target of Rapamycin Inhibitor Everolimus in Combination With Oral Topotecan for Recurrent and Advanced Endometrial Cancer

(2014) Carlos Acevedo-Gadea et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Hedgehog pathway as a potential treatment target in human cholangiocarcinoma

(2014) Dorothee Riedlinger et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition

(2014) Huajie Zong et al.   MOLECULAR BIOLOGY REPORTS

Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma

(2013) Pamela Leal et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The Prognostic Significance and Therapeutic Potential of Hedgehog Signaling in Intrahepatic Cholangiocellular Carcinoma

(2013) L. Tang et al.   CLINICAL CANCER RESEARCH

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions

(2013) Jesse S. Voss et al.   HUMAN PATHOLOGY

Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

(2013) Nataliya Razumilava et al.   JOURNAL OF HEPATOLOGY

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

Dishonorable Discharge: The Oncogenic Roles of Cleaved E-Cadherin Fragments

(2012) J. M. David et al.   CANCER RESEARCH

Inhibition of hedgehog signaling attenuates carcinogenesisin vitroand increases necrosis of cholangiocellular carcinoma

(2012) Mona El Khatib et al.   HEPATOLOGY

Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal

(2012) Mariana Rodova et al.   PLoS One

Metastatic Progression of Prostate Cancer and E-Cadherin

(2011) Aaron P. Putzke et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

(2011) H. Wong et al.   CLINICAL CANCER RESEARCH

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

(2010) Lisa Mohamet et al.   Journal of Oncology

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

(2009) B. Herberger et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells

(2008) Julie Douville et al.   STEM CELLS AND DEVELOPMENT