The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

A Mitochondrial VDAC1-Based Peptide Greatly Suppresses Steatosis and NASH-Associated Pathologies in a Mouse Model

(2019) Srinivas Pittala et al.   MOLECULAR THERAPY

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

(2018) Ray K Boyapati et al.   INFLAMMATORY BOWEL DISEASES

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β

(2018) Mar Cuadrado-Tejedor et al.   JOURNAL OF ALZHEIMERS DISEASE

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

Regulation of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κβ) in Inflammatory Bowel Diseases

(2018) Deenaz Zaidi et al.   Frontiers in Pediatrics

Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation

(2017) Sandra Heller et al.   FASEB JOURNAL

Inflammatory Bowel Disease 2017: Innovations and Changing Paradigms

(2017) Jean-Frederic Colombel et al.   GASTROENTEROLOGY

Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics

(2017) Konstantinos H. Katsanos et al.   Gut and Liver

Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation

(2017) Xiaowan Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tissue metabolism and the inflammatory bowel diseases

(2017) Jordi M. Lanis et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Loss of Response to Anti-TNFs: Definition, Epidemiology and Management

(2016) Giulia Roda et al.   Clinical and Translational Gastroenterology

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction

(2014) Shira Weisthal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

(2014) Adriane R. Neves et al.   INFLAMMATORY BOWEL DISEASES

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

(2014) Wei Dou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

The Unfolded Protein Response and Chemical Chaperones Reduce Protein Misfolding and Colitis in Mice

(2013) Stewart Siyan Cao et al.   GASTROENTEROLOGY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

MAVS Regulates Apoptotic Cell Death by Decreasing K48-Linked Ubiquitination of Voltage-Dependent Anion Channel 1

(2013) Kai Guan et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins

(2012) Shay Geula et al.   BIOCHEMICAL JOURNAL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

(2009) Yutao Yan et al.   PLoS One

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY