Article
Biochemistry & Molecular Biology
Shuangwen Li, Lisi Zheng, Jun Zhang, Xuejun Liu, Zhongming Wu
Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
XinDong Wang, HongDong Ma, Jun Sun, TianYu Zheng, Peng Zhao, HaiTian Li, MaoWei Yang
Summary: The incidence of type 2 diabetic osteoporosis (T2DOP) is rapidly increasing and its specific mechanism remains unclear. Studies have shown a relationship between iron overload and T2DOP. Mitochondrial ferritin (FtMt) may inhibit ferroptosis in osteoblasts by reducing oxidative stress caused by excess ferrous ions, while FtMt deficiency induces mitophagy in the pathogenesis of T2DOP. FtMt could potentially serve as a target for T2DOP therapy.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Endocrinology & Metabolism
Wei He, Lu Chang, Xinlu Li, Yan Mei
Summary: Ferroptosis is an iron-dependent form of cell death characterized by mitochondrial atrophy, increased mitochondrial membrane density, depletion of glutathione, inactivation of glutathione peroxidase 4, and an increase in lipid peroxides and divalent iron ions. While ferroptosis is associated with various diseases, its relationship with diabetic retinopathy (DR) has received less attention. This paper reviews the pathological mechanism of both ferroptosis and DR, and explores the role of ferroptosis in the pathology of DR, aiming to provide new insights for its clinical treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen
Summary: Hydralazine can protect renal proximal tubular epithelial cells from high glucose insults and prevent renal damage through XO/NADPH oxidase inhibition and Nrf2/HO-1 activation, indicating comprehensive antioxidation and anti-inflammation mechanisms for managing DN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Di Huang, Peicheng Shen, Chen Wang, Jiandong Gao, Chaoyang Ye, Feng Wu
Summary: This study found that calycosin has a protective effect on diabetic kidney disease, possibly through the inhibition of ferroptosis.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bingbing Zhu, Ji Fang, Zhengcai Ju, Ying Chen, Li Wang, Hao Wang, Lina Xing, Aili Cao
Summary: The study demonstrates that Zuogui Wan can improve diabetic nephropathy by inhibiting oxidative stress and podocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Article
Food Science & Technology
Tong Jin, Cheng Chen
Summary: The findings suggest that umbelliferone has a protective effect on diabetic nephropathy by activating the Nrf2/HO-1 pathway and attenuating high glucose-induced ferroptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Luxin Li, Yucen Dai, Dan Ke, Jieting Liu, Peijian Chen, Dong Wei, Tongtong Wang, Yanjie Teng, Xiaohuan Yuan, Zhen Zhang
Summary: Diabetic nephropathy (DN) and diabetic retinopathy (DR) are prevalent and dangerous global diseases associated with diabetes. The recently described cell death type, ferroptosis, has been found to play a role in the development of various diabetic complications. Disturbance in cellular iron metabolism triggers ferroptosis and is closely linked to diabetes. However, the molecular mechanism underlying the role of ferroptosis in DN and DR is still unclear and requires further study. This review article summarizes and evaluates the mechanism of ferroptosis and its role and progress in DN and DR, providing new insights for the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Maoying Wei, Xingxing Liu, Zhijuan Tan, Xiaochan Tian, Mingdi Li, Junping Wei
Summary: Diabetic nephropathy (DN) is a serious complication of diabetes and a leading cause of death in diabetes patients with end-stage renal disease. Ferroptosis, a newly discovered programmed cell death pattern characterized by excessive accumulation of intracellular lipid peroxides dependent on iron ions, has been shown to play an important role in the onset and development of DN. Chinese herbal medicine, with its long history and definite curative effect, has the potential to modulate ferroptosis in renal intrinsic cells and improve DN. This review outlines the key regulators and pathways of ferroptosis in DN and summarizes the herbs, mainly monomers and extracts, that target the inhibition of ferroptosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lorenzo Polimeno, Maria Teresa Viggiani, Floriana Giorgio, Lucrezia Polimeno, Deborah Fratantonio, Marina Di Domenico, Mariarosaria Boccellino, Andrea Ballini, Skender Topi, Alfredo Di Leo, Luigi Santacroce, Michele Barone
Summary: This study evaluated the expression of Nrf2 and Gfer in the early stage of colorectal cancer (CRC) and found that their expression levels were significantly reduced in colorectal adenoma tissues. This suggests that Nrf2 and Gfer may be involved in the multistep process of colon carcinogenesis. Further research is needed to confirm if Nrf2 and Gfer are potential risk/prognostic factors for cancer development.
DIGESTIVE AND LIVER DISEASE
(2022)