SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis

(2020) Da-Hye Lee et al.   Autophagy

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

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Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

(2018) Chenyao Wang et al.   Nature Communications

Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

(2017) Meng Li et al.   GUT

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3-Decylcatechol induces autophagy-mediated cell death through the IRE1α/JNK/p62 in hepatocellular carcinoma cells

(2017) Da-Hye Go et al.   Oncotarget

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway

(2016) Duo Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

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(2016) Zobair M. Younossi et al.   HEPATOLOGY

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

(2016) Kwang-Youn Kim et al.   Scientific Reports

The CBS/CSE system: a potential therapeutic target in NAFLD?

(2015) Lindsei K. Sarna et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms

(2015) Tsung-Cheng Chang et al.   GENOME RESEARCH

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

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(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Effect of feeding a high fat diet on hydrogen sulfide (H2S) metabolism in the mouse

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MiR-216a: a link between endothelial dysfunction and autophagy

(2014) R Menghini et al.   Cell Death & Disease

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis

(2013) Tae-Il Jeon et al.   Cell Metabolism

Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats

(2013) Zhu-Lin Luo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

iSNO-PseAAC: Predict Cysteine S-Nitrosylation Sites in Proteins by Incorporating Position Specific Amino Acid Propensity into Pseudo Amino Acid Composition

(2013) Yan Xu et al.   PLoS One

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

Androgen pathway stimulates MicroRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis

(2012) Po-Jen Chen et al.   HEPATOLOGY

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism

(2012) Xiwen Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

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(2012) Johannes Schindelin et al.   NATURE METHODS

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPS-SNO: Computational Prediction of Protein S-Nitrosylation Sites with a Modified GPS Algorithm

(2010) Yu Xue et al.   PLoS One

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

(2009) Paulina Pettinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

(2009) Sangita Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL