Review
Cell Biology
Xiao Yu, Qingyuan Zheng, Qiyao Zhang, Shuijun Zhang, Yuting He, Wenzhi Guo
Summary: MCM3AP-AS1, a novel lncRNA aberrantly expressed in human cancers, is significantly associated with clinical characteristics of tumors and modulates tumor progression by controlling cellular functions. It shows promise as a biomarker for cancer diagnosis, prognosis evaluation, and treatment, with potential clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pathology
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Alireza Gharebaghi, Reyhane Eghtedarian, Mohammad Taheri
Summary: Colorectal cancer is a common cancer with unclear underlying causes in most cases. Recent studies have highlighted the importance of long non-coding RNAs (lncRNAs) in the initiation, progression, and metastasis of CRC. Dysregulation of certain lncRNAs in CRC cells and tissues may serve as diagnostic and prognostic markers, and their involvement in autophagy regulation also suggests a potential role in modulating CRC cells' response to chemotherapy.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Xuqiang Zhu, Di Chen, Yiyu Sun, Shuo Yang, Weiguang Wang, Bing Liu, Peng Gao, Xueyuan Li, Lixin Wu, Siqi Ma, Wenyang Lin, Jiwei Ma, Dongming Yan
Summary: This study aimed to assess the value of WEE2-AS1 as a potential prognostic marker of glioma. The findings showed that WEE2-AS1 is overexpressed in various cancers, including glioma, and is associated with glioma progression. It was also determined that WEE2-AS1 expression may serve as an independent risk factor for the survival and prognosis of glioma patients.
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Qi-Nian Wu, Xiao-Jing Luo, Jia Liu, Yun-Xin Lu, Yun Wang, Jingjing Qi, Ze-Xian Liu, Qi-Tao Huang, Ze-Kun Liu, Jia-Bin Lu, Ying Jin, Heng-Ying Pu, Pei-Shan Hu, Jia-Bo Zheng, Zhao-Lei Zeng, Huai-Qiang Ju, Dan Xie, Qi Zhao, Ruihua Xu
Summary: This study identified a novel colorectal cancer biomarker and therapeutic target, MNX1-AS1, a long noncoding RNA that drives proliferation through the MYC/MNX1-AS1/YB1 signaling pathway. These findings suggest that the MYC-MNX1-AS1-YB1 axis could potentially serve as a biomarker and therapeutic target in colorectal cancer.
Article
Medicine, Research & Experimental
Guang-Hui Lu, Hui-Meng Zhao, Zi-Yuan Liu, Qun Cao, Run-Dong Shao, Gang Sun
Summary: The study found that SAMD12-AS1 is highly up-regulated in gastric cancer tissues and cells, and is closely related to patient survival time and TNM staging. SAMD12-AS1 promotes the progression of GC by interacting with DNMT1 to inhibit the P53 signaling pathway.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Tengfei Li, Shuai Zhou, Yan Yang, Yanyan Xu, Xin Gong, Yunsheng Cheng, Yong Wang
Summary: This article highlights the crucial role of long non-coding RNAs (lncRNAs) in cancer pathogenesis and specifically focuses on the potential functions of MNX1-AS1 in various cancer types and its potential as a therapeutic target.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Yajing Zhao, Xingguo Song, Xianrang Song, Li Xie
Summary: This study identified core ceRNAs and investigated diagnostic biomarkers in CRC through constructing an exosomal ceRNA network.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Review
Chemistry, Medicinal
Chengyu Hu
Summary: This review discusses the molecular mechanisms and clinical significance of the oncogene DSCAM-AS1 in various tumor types. Overexpression of DSCAM-AS1 is associated with cancer progression and invasion, making it a potential therapeutic target or tumor biomarker.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Lin Zhuang, Wenbin Ding, Wei Ding, Qi Zhang, Xuezhong Xu, Dong Xi
Summary: Long noncoding RNAs play crucial roles in colorectal cancer, with the interaction between ZNF667-AS1 and ANK2/JAK2 potentially affecting CRC progression. Overexpression of ZNF667-AS1 can inhibit the proliferation, migration, and invasion of CRC cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Qian Lu, Jun Lou, Ruyun Cai, Weidong Han, Hongming Pan
Summary: Long non-coding RNAs play crucial roles in various cancers, with SBF2-AS1 identified as a highly expressed lncRNA associated with poor prognosis and involved in tumor progression. Its potential as a diagnostic, prognostic biomarker and therapeutic target is highlighted.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Minghui Wang, Zhijun Zhang, Deng Pan, Zhigang Xin, Fan Bu, Yue Zhang, Qingwu Tian, Xiaodong Feng
Summary: This study identified two lncRNAs, UCA1 and PGM5-AS1, in the plasma of CRC patients, which have the potential to be used as diagnostic biomarkers for CRC. The diagnostic potential of these lncRNAs is even higher for early-stage CRC.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Neda Yaghoubi, Farnaz Zahedi Avval, Majid Khazaei, Seyed Hamid Aghaee-Bakhtiari
Summary: miRNAs, as highly sensitive and specific markers, play important roles in the diagnosis, prognosis, and treatment of colorectal cancer. They can serve as quantifiable and effective molecular tools, offering potential new strategies for early cancer detection and treatment.
CELLULAR SIGNALLING
(2021)
Article
Pharmacology & Pharmacy
Z. -X Lin, L. -H Zhu, J. -Y Huang, Y. -Y Huang, X. Lin
Summary: This study found that paclitaxel-resistant lncRNA DBH-AS1 promotes proliferation and invasion of ECa cells by acting as a ceRNA and regulating the miR-21-5p/YOD1 signaling pathway. This finding provides new insights and methods for overcoming drug resistance in cancer treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Xiaoping Zhang, Dan Li, Chengyou Jia, Haidong Cai, Zhongwei Lv, Bo Wu
Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.
CELL DEATH & DISEASE
(2021)
Article
Nutrition & Dietetics
Golbarg Rahimi, Salime Heydari, Bahareh Rahimi, Navid Abedpoor, Iman Niktab, Zahra Safaeinejad, Maryam Peymani, Farzad Seyed Forootan, Zahra Derakhshan, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi
Summary: The combination therapy of SPTC with exercise or metformin showed more beneficial effects in preventing the development of diabetes and oxidative stress associated with hyperglycemia, by improving oxidative stress hemostasis through activating the Nrf2 signaling pathway and attenuating keap1 protein expression.
NUTRITION & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Abbas Samadi-Khouzani, Payam Kheirmand Parizi, Fatemeh Ghafari, Seyed-Alireza Esmaeili, Maryam Peymani, Amir Abbas Momtazi-Borojeni
Summary: The study did not find an association between the rs619586 (A/G) polymorphism in the gene encoding lncRNA-MALAT1 and susceptibility to T2DM in the Isfahan population.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Correction
Nutrition & Dietetics
Golbarg Rahimi, Salime Heydari, Bahareh Rahimi, Navid Abedpoor, Iman Niktab, Zahra Safaeinejad, Maryam Peymani, Farzad Seyed Forootan, Zahra Derakhshan, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi
Summary: The paper has been amended and the revisions can be found in the original article.
NUTRITION & METABOLISM
(2021)
Article
Cell Biology
Masoud Baghi, Elaheh Yadegari, Mahsa Rostamian Delavar, Maryam Peymani, Mazdak Ganjalikhani-Hakemi, Mehri Salari, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw, Kamran Ghaedi
Summary: PGC-1 alpha/FNDC5/BDNF pathway plays a critical role in neurodegeneration. Dysregulation of miRNA is found to be decisive in PD. MiR-193b may function in PD development by regulating PGC-1 alpha/FNDC5/BDNF pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andisheh Oroujalian, Maryam Peymani, Kamran Ghaedi
Summary: Breast cancer is the most common cancer in women worldwide, and genetic mutations and tumor suppressor genes play important roles in its development. This study found an association between the rs73092672 genotype and breast cancer risk, with a higher binding affinity of the T allele in the 3'UTR of hsa-miR-509-5p.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2021)
Article
Cell Biology
Leila Bahmani, Masoud Baghi, Maryam Peymani, Arash Javeri, Kamran Ghaedi
Summary: The study revealed that miR-141-3p and miR-200a-3p are Th17 cell-associated miRNAs, and their expression is significantly upregulated during Th17 cell induction. Additionally, the RARB gene is identified as a direct target of both miRNAs, and its downregulation may affect the transcriptional level of JAK/STAT pathway genes.
Article
Oncology
Noushin Miralaei, Ahmad Majd, Kamran Ghaedi, Maryam Peymani, Masoomeh Safaei
Summary: The AURKA gene is overexpressed in common cancers and is associated with poor prognosis and drug resistance. Some chemotherapy drugs can reduce the expression of this gene.
Article
Pathology
Nasrin Nazempour, Mohammad Hossein Taleqani, Navid Taheri, Amir Hossein Haji Ali Asgary Najafabadi, Alireza Shokrollahi, Atefeh Zamani, Nasrin Fattahi Dolatabadi, Maryam Peymani, Mohammad Mahdevar
Summary: This study identified 66 overexpressed cell surface proteins in colorectal cancer. Additionally, 146 CSPs were found to be associated with poor prognosis features in TCGA data, with TIMP1 and QSOX2 independently linked to poor patient survival. High-risk patients had higher fatality rates based on the risk score calculated from the expression levels of these genes. Furthermore, QSOX2 and TIMP1 expression levels were higher in tumor samples compared to adjacent normal samples.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohammad Mahdevar, Jafar Vatandoost, Farzad Seyed Forootan, Abbas Kiani-Esfahani, Maryam Esmaeili, Maryam Peymani, Hamid Tavakkoli, Ali Osmay Gure, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi
Summary: The study found that lncRNA SRA is dysregulated in CRC tissue, acting as an oncogene through the OXPHOS pathway and serving as a potential biomarker for identifying CRC subtype with KRAS mutations. KRAS mutant samples had the highest SRA1 expression level. Therefore, lncRNA SRA might be a therapeutic target to inhibit cell proliferation in CRC.
Article
Biochemistry & Molecular Biology
Parisa Ghanizade, Andisheh Oroujalian, Maryam Peymani
Summary: This study compared the expression of CCDC107 and RMRP in CRC and adjacent normal tissues, finding that CCDC107 was significantly down-regulated in patients and could serve as a biomarker for diagnostic purposes in CRC, while RMRP expression did not show significant alterations.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Mehdi Roshanian Bakhsh, Maryam Peymani, Leila Rouhi, Kamran Ghaedi
Summary: This study aimed to introduce a new conventional chemotherapy drug based on the transcriptome of TNBC patients. Through analyzing gene expression differences in the presence of different drugs, Rapamycin was identified as a suitable drug for TNBC treatment. Rapamycin significantly affected the viability and apoptosis rate of TNBC cells.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Article
Genetics & Heredity
Mandana Kazemi, Maryam Peymani
Summary: This study aimed to evaluate the expression of Th17 axis genes in CRC, showing that certain genes like IL-17A, IL-17F, and IL-22 increased in expression, while others decreased in CRC tissues. Although no significant correlation was found between gene expression levels and patient survival, these genes could serve as specific biomarkers for CRC diagnosis. Th17 axis genes may be useful biomarkers for both diagnosis and prognosis of CRC.