Heat shock proteins with an emphasis on HSP 60

Heat shock phenomenon is a process by which cells express a set of proteins called heat shock proteins (HSPs) against heat stress. HSPs include several families depending upon the molecular weight of the respective protein. Among the different HSPs, The HSP60 is one of the main components representing the framework of chaperone system. HSP60 plays a myriad number of roles like chaperoning, thermotolerance, apoptosis, cancer, immunology and embryonic development. In this review we discussed briefly the general knowledge and focussed on HSP60 in terms of structure, regulation and function in various physiological and pathological conditions.

Automated summary

Heat shock phenomenon is a cellular response to heat stress where cells express a group of proteins called heat shock proteins (HSPs). Among these proteins, HSP60 plays a crucial role in various processes such as chaperoning, thermotolerance, apoptosis, cancer, immunology, and embryonic development. This review focuses on the general knowledge of heat shock phenomenon and specifically highlights the structure, regulation, and functions of HSP60 in different physiological and pathological conditions.