Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Immunology
Jingfei Yao, Dongmei Wu, Yifu Qiu
Summary: This article reviews the important contribution of adipose tissue macrophage (ATM) to obesity-related metabolic diseases, including its regulation of metabolic homeostasis and dysfunction, macrophage polarization and recruitment, as well as the crosstalk between ATM and adipocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sergio Quesada-Vazquez, Anna Antolin, Marina Colom-Pellicer, Gerard Aragones, Laura Herrero, Josep Maria Del Bas, Antoni Caimari, Xavier Escote
Summary: A specific combination of metabolic cofactors showed promising results in treating obesity in a high-fat diet mouse model. The combination reduced obesity and adiposity, improved glucose and lipid metabolic parameters, increased lipid oxidation, and decreased adipocyte hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sheng Hu, Yong Hu, Wei Yan
Summary: Under physiological conditions, the body maintains metabolic homeostasis through interorgan communication, which is mediated by hormones, metabolites, and extracellular vesicles (EVs). EVs play a role in interorgan communication by encapsulating bioactive cargoes and have implications in cancer, obesity, diabetes, and cardiovascular disease. This review summarizes the latest research on EV biogenesis, secretion, and components, as well as their potential applications as diagnostic markers and therapeutic strategies for metabolic disorders.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Multidisciplinary Sciences
Yang Wu, Tao Peng, Yu Chen, Li Huang, Bisong He, Shaobin Wei
Summary: This study aims to evaluate the effectiveness and safety of acupuncture for insulin resistance and lipid metabolic disorder of women with PCOS. Randomized controlled trials (RCTs) of acupuncture therapy for PCOS will be included, data analysis will be conducted independently by two or more reviewers, calculating mean difference (MD), standard mean difference (SMD), and 95% confidence intervals (CIs), and data synthesis will be performed using RevMan V.5.3 software and Stata V.15.0 software when necessary.
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Endocrinology & Metabolism
Guillaume Treiber, Marie-Paule Gonthier, Alice Guilleux, Samir Medjane, Oriane Bonfanti, Muriel Cogne, Olivier Meilhac, Estelle Nobecourt
Summary: This study compared the levels of inflammatory biomarkers between patients with FPLD2 and patients with obesity. The results showed that adiponectin and leptin levels were lower in the FPLD2 group than in the obesity group, while MCP-1 levels were higher. This indicates different inflammatory profiles between the two adipose tissue pathologies.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ferran Comas, Jose Maria Moreno-Navarrete
Summary: Hydrogen sulfide (H2S) has emerged as a new signaling molecule, playing extensive physiological and pathophysiological roles in human disorders by targeting proteins, enzymes, and transcription factors through post-translational modification known as persulfidation. This review article critically examines the current literature on the role of H2S in obesity-related metabolic disturbances, particularly its mechanisms of action.
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Umesh K. Goand, Saurabh Verma, Inklisan Patel, Saima Tasneem, Richa Garg, Jiaur R. Gayen
Summary: This study aimed to investigate the immunometabolic effect of PST inhibitor (PSTi8) against PST. The results showed that PSTi8 inhibited the expression of lipolytic genes and proteins in 3T3-L1 adipocytes, improved insulin sensitivity and lipid metabolism. Moreover, PSTi8 promoted macrophage polarization, reduced inflammation, and improved energy expenditure. Therefore, PSTi8 may be a potential therapeutic approach for obesity and insulin resistance.
Article
Nutrition & Dietetics
Caitlyn Nguyen-Ngo, Anthony V. Perkins, Martha Lappas
Summary: Gestational diabetes mellitus (GDM) and maternal obesity have long-term detrimental impacts on the health of both mother and offspring. Increased inflammation and oxidative stress play key roles in the pathophysiology of these metabolic conditions. This study found that selenium supplementation may prevent inflammation and oxidative stress associated with GDM and maternal obesity.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
