Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors

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CRISPR-DT: designing gRNAs for the CRISPR-Cpf1 system with improved target efficiency and specificity

(2019) Houxiang Zhu et al.   BIOINFORMATICS

Combinatorial pathway enzyme engineering and host engineering overcomes pyruvate overflow and enhances overproduction of N-acetylglucosamine in Bacillus subtilis

(2019) Wenlong Ma et al.   Microbial Cell Factories

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

(2019) Yuanyuan Wang et al.   Nature Communications

Equilibrium of the intracellular redox state for improving cell growth and l-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping

(2019) Jian-Zhong Xu et al.   Microbial Cell Factories

The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU

(2019) Sarah J. Morgan et al.   PLoS One

The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain

(2019) Melek Cemre Manav et al.   STRUCTURE

Synergetic engineering of central carbon and nitrogen metabolism for the production of N ‐acetylglucosamine in Bacillus subtilis

(2019) Tengfei Niu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Recent trends in metabolic engineering of microbial chemical factories

(2019) Yi Liu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Development of N -acetylneuraminic acid responsive biosensors based on the transcriptional regulator NanR

(2018) Gert Peters et al.   BIOTECHNOLOGY AND BIOENGINEERING

Synthetic Repetitive Extragenic Palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells

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Engineering TATA-binding protein Spt15 to improve ethanol tolerance and production in Kluyveromyces marxianus

(2018) Pengsong Li et al.   Biotechnology for Biofuels

Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA)

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CRISPRi allows optimal temporal control of N-acetylglucosamine bioproduction by a dynamic coordination of glucose and xylose metabolism in Bacillus subtilis

(2018) Yaokang Wu et al.   METABOLIC ENGINEERING

Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis

(2018) Yang Gu et al.   METABOLIC ENGINEERING

Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum

(2018) Wenjun Wu et al.   METABOLIC ENGINEERING

CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum

(2017) Yu Jiang et al.   Nature Communications

Engineering Cellular Metabolism

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Engineering cytosolic acetyl-coenzyme A supply in Saccharomyces cerevisiae : Pathway stoichiometry, free-energy conservation and redox-cofactor balancing

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Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloids

(2016) Wei Qiang et al.   PHYTOCHEMISTRY

HISAT: a fast spliced aligner with low memory requirements

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Metabolic engineering for improved production of ethanol by Corynebacterium glutamicum

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HTSeq--a Python framework to work with high-throughput sequencing data

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Microbial production of amino acids and derived chemicals: Synthetic biology approaches to strain development

(2014) Volker F Wendisch   CURRENT OPINION IN BIOTECHNOLOGY

Genome-Wide Analysis of the Role of Global Transcriptional Regulator GntR1 in Corynebacterium glutamicum

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From zero to hero – Production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum

(2014) Stefanie Kind et al.   METABOLIC ENGINEERING

Construction of a novel expression system for use in Corynebacterium glutamicum

(2014) Jinyu Hu et al.   PLASMID

Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

(2013) Paulo A. Gameiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine

(2013) Yanfeng Liu et al.   METABOLIC ENGINEERING

Engineering of formate dehydrogenase: synergistic effect of mutations affecting cofactor specificity and chemical stability

(2012) Kathrin Hoelsch et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Interaction of GlnK with the GAF domain of Herbaspirillum seropedicae NifA mediates NH4+-regulation

(2012) Marco A.S. Oliveira et al.   BIOCHIMIE

Coordinated Regulation ofgnd, Which Encodes 6-Phosphogluconate Dehydrogenase, by the Two Transcriptional Regulators GntR1 and RamA in Corynebacterium glutamicum

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Relative potential of biosynthetic pathways for biofuels and bio-based products

(2011) Deepak Dugar et al.   NATURE BIOTECHNOLOGY

Pyrazine Biosynthesis in Corynebacterium glutamicum

(2010) Jeroen S. Dickschat et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Adaptation of AmtR-controlled gene expression by modulation of AmtR binding activity in Corynebacterium glutamicum

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N-Acetylglucosamine: Production and Applications

(2010) Jeen-Kuan Chen et al.   Marine Drugs

The transcriptional regulators RamA and RamB are involved in the regulation of glycogen synthesis in Corynebacterium glutamicum

(2010) G. M. Seibold et al.   MICROBIOLOGY-SGM

L-Glutamine as a nitrogen source for Corynebacterium glutamicum: derepression of the AmtR regulon and implications for nitrogen sensing

(2010) N. Rehm et al.   MICROBIOLOGY-SGM

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

The GlxR regulon of the amino acid producer Corynebacterium glutamicum: Detection of the corynebacterial core regulon and integration into the transcriptional regulatory network model

(2009) Thomas A. Kohl et al.   JOURNAL OF BIOTECHNOLOGY

Transcriptional control of the succinate dehydrogenase operon sdhCAB of Corynebacterium glutamicum by the cAMP-dependent regulator GlxR and the LuxR-type regulator RamA

(2009) Michael Bussmann et al.   JOURNAL OF BIOTECHNOLOGY

Regulation of ldh expression during biotin-limited growth of Corynebacterium glutamicum

(2009) C. Dietrich et al.   MICROBIOLOGY-SGM

Simultaneous utilization of d-cellobiose, d-glucose, and d-xylose by recombinant Corynebacterium glutamicum under oxygen-deprived conditions

(2008) Miho Sasaki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Involvement of the LuxR-Type Transcriptional Regulator RamA in Regulation of Expression of thegapAGene, Encoding Glyceraldehyde-3-Phosphate Dehydrogenase ofCorynebacterium glutamicum

(2008) Koichi Toyoda et al.   JOURNAL OF BACTERIOLOGY

Regulation of the expression of phosphoenolpyruvate : carbohydrate phosphotransferase system (PTS) genes in Corynebacterium glutamicum R

(2008) Y. Tanaka et al.   MICROBIOLOGY-SGM