Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration

Targeting Intrinsically Disordered Proteins through Dynamic Interactions

(2020) Jianlin Chen et al.   Biomolecules

Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease

(2019) Kaushik Kumar Dey et al.   Clinical Proteomics

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell

(2019) Antonio Deiana et al.   PLoS One

Targeting intrinsically disordered proteins involved in cancer

(2019) Patricia Santofimia-Castaño et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2

(2018) Meenakshisundaram Balasubramaniam et al.   Scientific Reports

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

(2018) Franziska Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding of poly-amino acids and intrinsically disordered proteins in overcrowded milieu induced by pH change

(2018) Alexander V. Fonin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sequence fingerprints distinguish erroneous from correct predictions of intrinsically disordered protein regions

(2017) Konda Mani Saravanan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Proteus: a random forest classifier to predict disorder-to-order transitioning binding regions in intrinsically disordered proteins

(2017) Sankar Basu et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls

(2016) Srinivas Ayyadevara et al.   AGING CELL

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

(2014) Srinivas Ayyadevara et al.   AGING CELL

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2014) Ghulam Ashraf et al.   CNS & Neurological Disorders-Drug Targets

Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation

(2014) Guodong Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Morbidity risks among older adults with pre-existing age-related diseases

(2013) Igor Akushevich et al.   EXPERIMENTAL GERONTOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics