期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112125
关键词
Chitosan; Vanillin; Crosslinking; Solvent casting; Drug-polymer solubility; Controlled drug release; Transdermal delivery
资金
- Internal Grant Agency of Tomas Bata University in Zlin, Czech Republic [IGA/CPS/2021/001]
- Ministry of Education, Youth and Sports of the Czech Republic [LTACH17015, RP/CPS/2020/001]
- Slovenian Research Agency, Slovenia [L22616]
- NPU Program I [LO1504]
The study successfully achieved sustained release of ENR drug by preparing CS-PVA blend matrix transdermal system, characterized properties changes of blend films before and after crosslinking, and found that increasing vanillin concentration changed the diffusion mechanism. The results suggest that these matrix films have the potential to be applied in transdermal drug delivery systems.
In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.
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