Article
Biochemistry & Molecular Biology
Muhammad Umar, Azeem Ullah, Hifza Nawaz, Tanzeel Areeb, Motahira Hashmi, Davood Kharaghani, Kyu Oh Kim, Ick Soo Kim
Summary: The study developed bi-component alginate-hyaluronic acid (AHA) fibers with improved mechanical performance and high liquid absorption. The controlled release of hyaluronic acid, high biocompatibility towards cell lines, and suitable MVTR values make the fibers appropriate for promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Ji-Soo Park, Chan-Woo Park, Song-Yi Han, Eun-Ah Lee, Azelia Wulan Cindradewi, Jeong-Ki Kim, Gu-Joong Kwon, Young-Ho Seo, Won-Jae Yoo, Jaegyoung Gwon, Seung-Hwan Lee
Summary: The mechanical properties of alginate fibers were improved by reinforcing with various cellulose nanofibrils. Tensile strength and elastic modulus increased with CNF content up to 10%, but deteriorated with 30% CNF addition. The order of tensile properties was LCNF/AL > PCNF/AL > TOLCNF/AL > AL, and an increase in spinning rate improved the properties.
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Zhenning Zhang, Zhipeng Ni, Yudi Huang, Hua Zhang, Zhewei Hu, Di Ye, Yihua Shen, Mengyan Jia, Kehang Shi, Ge Zhu, Jin He, Lichang Xu, Fushan Shi, Haojie Yu, Lenan Zhuang, Huanan Wang
Summary: Currently, the use of antibiotics to treat bacterial infections is facing a challenge due to the abuse of antibiotics and the emergence of drug-resistant bacteria. In order to develop alternative antimicrobial agents, a polymer called PZBA-PVA hydrogel was synthesized based on the structure of barnacle cement protein. This hydrogel showed good biocompatibility, high antibacterial activity, and improved wound healing in both in vitro and in vivo experiments. Overall, the PZBA-PVA hydrogel has great potential for the treatment of infected wounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Paper & Wood
Faheem Ahmad, Bushra Mushtaq, Faaz Ahmed Butt, Abher Rasheed, Sheraz Ahmad
Summary: A novel biodegradable composite of sodium alginate hydrogel with wool needle-punched nonwoven fabric was developed for wound dressing, showing increased wound exudate absorbing capacity, enhanced tensile strength, and improved moisture management properties. The unique combination provides a moist environment and promotes cell proliferation during the wound healing process.
Article
Biochemistry & Molecular Biology
Ryota Teshima, Shigehito Osawa, Miki Yoshikawa, Yayoi Kawano, Hidenori Otsuka, Takehisa Hanawa
Summary: A low-adhesion and low-swelling hydrogel dressing has been developed using alginate, calcium carbonate, and carbonated water. The dressing exhibited reduced skin adhesion and swelling compared to clinical low-adhesion hydrogel dressings. In vivo tests demonstrated its therapeutic efficacy in promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Polymer Science
Ji-Soo Park, Song-Yi Han, Rajkumar Bandi, Eun-Ah Lee, Azelia-Wulan Cindradewi, Jeong-Ki Kim, Gu-Joong Kwon, Young-Ho Seo, Won-Jae Youe, Jaegyoung Gwon, Chan-Woo Park, Seung-Hwan Lee
Summary: Lignocellulose nanofibrils (LCNFs) with different lignin contents were successfully prepared and it was found that the addition of sodium alginate can significantly improve the wet-spinnability of the fibers, but deteriorate their tensile properties.
Review
Biochemistry & Molecular Biology
Ankur Sood, Atul Dev, Sabya Sachi Das, Hyeon Jin Kim, Anuj Kumar, Vijay Kumar Thakur, Sung Soo Han
Summary: Hydrogels have become a versatile platform for biomedical applications due to their ability to absorb biofluids. Natural polymers, such as alginate, are attractive options for hydrogel design because of their biocompatibility and biodegradability. This review focuses on curcumin encapsulated alginate hydrogel matrix for wound healing and cancer therapy, discussing the mechanistic effects of curcumin and different approaches to designing curcumin loaded alginate hydrogels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Ganzhe Mao, Shuya Tian, Yanxia Shi, Jiahui Yang, Haiying Li, Hongbo Tang, Wenzhi Yang
Summary: In this study, a novel sodium alginate-arginine-zinc ion (SA-Arg-Zn2+) hydrogel was developed for skin wound dressings. The hydrogel showed high swelling ability, antioxidative activity, and strong antibacterial properties. The wound healing efficacy of SA-Arg-Zn2+ hydrogel was superior to other dressings, with a wound closure ratio of 100% on the 14th day. Additionally, the hydrogel down-regulated inflammatory factors and promoted the production of growth factors. Overall, SA-Arg-Zn2+ hydrogel is an effective and promising wound dressing material.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Inyoung Choi, Youngwoo Lee, Ji Sou Lyu, Jung-Soo Lee, Jaejoon Han
Summary: Calcium ions are commonly used to crosslink alginate films for better mechanical properties. However, due to the poor water resistance of alginate films, various ion-crosslinking agents have been used to prepare alginate films with different valences. The properties of these crosslinked films were evaluated, and FeSO4 was found to have the potential to improve water resistance. The water vapor permeability and swelling index of FeSO4-crosslinked film were significantly reduced with increased crosslinking time.
FOOD HYDROCOLLOIDS
(2022)
Article
Polymer Science
Muhammad Zahid, Maria Lodhi, Ayesha Afzal, Zulfiqar Ahmad Rehan, Muzzamil Mehmood, Talha Javed, Rubab Shabbir, Dorota Siuta, Fayez Althobaiti, Eldessoky S. Dessok
Summary: This study synthesized a wound-healing hydrogel based on radish seeds and demonstrated its effectiveness in healing cutaneous lesions. The higher the concentration of radish seed extract, the better the healing effect.
Article
Biochemistry & Molecular Biology
Shengbo Li, Xuemei Wang, Jing Chen, Jiahe Guo, Meng Yuan, Gui Wan, Chengqi Yan, Wenqing Li, Hans-Guenther Machens, Yuval Rinkevich, Xiaofan Yang, Heng Song, Zhenbing Chen
Summary: Chronic non-healing diabetic wounds and ulcers are a major challenge in the medical field. In this study, a hydrogel with pro-angiogenesis and antibacterial properties was developed, showing potential clinical application in refractory wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Ziyi Xu, Ji Zhou, Dan Li, Ge Zhu, Ning Lin
Summary: This study investigates the covalent grafting of polyaniline (PANI) onto cellulose nanocrystals (CNCs) to prepare composite conductive fibers with improved properties. The wet spinning process resulted in fibers with good tensile strength, electrical conductivity, and flexibility. These composite fibers have potential applications in antistatic textiles and the electronic industry.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Instruments & Instrumentation
Majid Salehi, Arian Ehterami, Saeed Farzamfar, Ahmad Vaez, Somayeh Ebrahimi-Barough
Summary: The alginate/naringenin hydrogel developed in this study showed positive effects on wound healing process, with appropriate porosity and biodegradability, as well as no toxicity to cells. In the rat experiment, the hydrogel containing 20% naringenin demonstrated the best wound closure among other groups.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Materials Science, Textiles
Yan Zheng, Lu Jin, Jing Qi, Zekun Liu, Lulu Xu, Steven Hayes, Simeon Gill, Yi Li
Summary: Lock-stitch embroidery is a versatile and precise method for producing conductive tracks in wearable electronic devices. This study evaluates the appearance quality, dimensional stability, and electrical resistance of conductive tracks by adjusting embroidery parameters such as speed, stitch length, thread tension, and direction. The results show that stitching in the wale direction produces more uniform stitch lines. To address floated stitches, a stitch length of 4 mm and higher thread tension are recommended. Shrinkage is lower in the wale direction. The electrical resistance of the conductive tracks increases with higher speed and shorter stitch length. Thicker yarns are more sensitive to thread tension, and some silver coating may rub off. Overlay plot analysis is used to predict and validate optimal embroidery parameters for balancing appearance quality and electrical resistance.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Chemistry, Multidisciplinary
Zekun Liu, Yan Zheng, Lu Jin, Kaili Chen, Heng Zhai, Qiyao Huang, Zhongda Chen, Yangpeiqi Yi, Muhammad Umar, Lulu Xu, Gang Li, Qingwen Song, Pengfei Yue, Yi Li, Zijian Zheng
Summary: This paper presents a novel wearable strain sensor with high sensitivity and wide sensing range, which is breathable and insensitive to pressure and bending stimuli. It offers a new route for achieving comfortable, high-performance, and anti-jamming strain sensors.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Zekun Liu, Tianxue Zhu, Junru Wang, Zijian Zheng, Yi Li, Jiashen Li, Yuekun Lai
Summary: This paper reviews the latest advances in fiber-based wearable strain sensors, including the methods for preparing conductive fibers, the fabrication and sensing mechanisms of state-of-the-art sensors, and their applications in various fields. It also critically analyzes the challenges and future prospects of fiber-based strain sensors.
NANO-MICRO LETTERS
(2022)
Article
Cell Biology
Hatem Jouda, Luis Larrea Murillo, Tao Wang
Summary: Coronary heart disease is caused by arterial narrowing or blockage due to atherosclerosis, and coronary artery bypass grafting is a commonly used treatment. Tissue engineered vascular grafts are in demand as alternatives when autologous vessels are not available. However, producing clinically viable and long-lasting TEVGs remains challenging.
Article
Nanoscience & Nanotechnology
Wenyuan Wei, Yangpeiqi Yi, Jun Song, Xiaogang Chen, Jinhua Li, Jiashen Li
Summary: Tunable temperature alarm sensors prepared using multilayer graphene and nitrocellulose can reliably monitor early high temperature risks. The sensors have a quick response time and superior flame retardancy property, and the response temperature and time can be adjusted by tuning the graphene/NC ratios to reduce fire risk in different scenarios.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jun Song, Luis Larrea Murillo, Kai Yang, Jiashen Li, Yi Li, Yu Chen, Zhongda Chen
Summary: This study proposes a reversible fibrous rod as a potential alternative for a rib internal fixation system, overcoming the limitations of traditional titanium alloy scaffolds. The fibrous rod exhibits mechanical properties that match those of the human rib, enabling it to fix rib fractures in situ while maintaining sufficient flexibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Yangpeiqi Yi, Chuang Yu, Heng Zhai, Lu Jin, Dongxu Cheng, Yifeng Lu, Zhongda Chen, Lulu Xu, Jiashen Li, Qinwen Song, Pengfei Yue, Zekun Liu, Yi Li
Summary: This article reports a new type of humidity sensor that achieves high reliability in humidity measurement by creating a stable open porous structure and controlling the number of oxygen-related groups. It has wide potential applications.
Article
Engineering, Environmental
Jing Liu, Junze Zhang, Zeyu Zhao, Yanping Liu, Wai Cheong Tam, Zhaozhu Zheng, Xiaoqin Wang, Yuling Li, Zekun Liu, Yi Li, Gang Li
Summary: In this study, a strain sensor using silk/polyurethane composite yarns with a core-sheath structure was designed and fabricated. The sensor exhibited fast response speed (80 ms), high durability (>1500 cycles), remarkable linear sensing feature (R2 = 99.8%) throughout the whole working range, and negative resistance response towards strain deformation. Moreover, it was not affected by temperature and humidity changes in typical use conditions. Experimental results showed its huge potentials for future personalized healthcare and public health management.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xueyang Ren, Yunfan Zhou, Fangzhou Lu, Leili Zhai, Hao Wu, Zhongda Chen, Changxian Wang, Xuefei Zhu, Yandong Xie, Pingqiang Cai, Juan Xu, Xianglong Tang, Jianqing Li, Jin Yao, Qin Jiang, Benhui Hu
Summary: A contact lens strain sensor with an anti-jamming ability is introduced, which reduces interference from tangential force by utilizing a self-lubricating layer to lower the coefficient of friction (COF). The strain concentration layout and confined occurrence of sympatric microcracks contribute to the sensor's high sensitivity. Animal tests prove that our lens can accurately and safely detect intraocular pressure (IOP).
Article
Materials Science, Multidisciplinary
Jinlin Chang, Chen Meng, Bowen Shi, Wenyuan Wei, Renzhi Li, Jinmin Meng, Haobin Wen, Xiangyu Wang, Jun Song, Zhirun Hu, Zekun Liu, Jiashen Li
Summary: In this study, an ultra-thin, flexible, and porous Cu/PLLA fibrous membrane was developed with excellent breathability and high electrical conductivity. The membrane showed fast electrical heating characteristics and effective thermal conductivity for thermal management, as well as enhanced electromagnetic interference shielding effectiveness. It has great potential for future portable electronic devices and wearable integrated garments.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Ting Liu, Zihan Lu, Heng Zhai, Jinmin Meng, Jun Song, Yan Zhang, Jingang Liu, Jiashen Li
Summary: Hierarchical porous poly(L-lactic acid) PLLA@ TiO2 fibrous membranes were fabricated using electrospinning/post-treatment method. The induced crystallization of PLLA chains in acetone post-treatment created a unique blooming porous structure, increasing the specific surface area and exposing TiO2 nanoparticles on the fiber surface. The porous PLLA@TiO2-0.1 membrane with a PLLA:TiO2 weight ratio of 1:5 achieved the highest photocatalytic efficiency.
Article
Engineering, Electrical & Electronic
Lu Jin, Zhenhong Li, Zekun Liu, Bethany Richardson, Yan Zheng, Lulu Xu, Zhongda Chen, Heng Zhai, Hongdoo Kim, Qingwen Song, Pengfei Yue, Sheng Quan Xie, Kap Jin Kim, Yi Li
Summary: This paper introduces a novel strategy involving unimodal tension, bend, shear, and twist strain sensors for detecting and differentiating individual strain modes in complex motions, potentially revolutionizing the development of motion recognition and control systems.
NPJ FLEXIBLE ELECTRONICS
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)