Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Biology
Victor Nozais, Stephanie J. Forkel, Laurent Petit, Lia Talozzi, Maurizio Corbetta, Michel Thiebaut de Schotten, Marc Joliot
Summary: Resting-state functional magnetic resonance imaging has shown that functional connectivity within and between networks is related to cognitive states and pathologies. However, the white matter connections supporting this connectivity have only been partially described. A new method has been developed to map the white and grey matter contributing to each resting-state network, demonstrating the overlap between networks and the potential impact of white matter lesions on network communication. An atlas and open-source software have been provided to facilitate the study of white matter damage to resting-state networks, with initial application showing promising results in identifying impacted networks in stroke patients.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Zhen-Zhen Ma, Jia-Jia Wu, Xu-Yun Hua, Mou-Xiong Zheng, Xiang-Xin Xing, Si-Si Li, Chun-Lei Shan, Wei Ding, Jian-Guang Xu
Summary: This study aimed to investigate abnormal dynamic functional connectivity (dFC) in patients with post-facial paralysis synkinesis (PFPS). The results showed that temporal properties, such as mean dwell time (MDT) and occurrence frequencies, rather than dFC patterns, significantly differed between PFPS patients and healthy controls. Additionally, aberrant dFC was found to be associated with facial nerve function, suggesting a fundamental feature of brain dysfunction in PFPS patients.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Francesca Bottino, Martina Lucignani, Luca Pasquini, Michele Mastrogiovanni, Simone Gazzellini, Matteo Ritrovato, Daniela Longo, Lorenzo Figa-Talamanca, Maria Camilla Rossi Espagnet, Antonio Napolitano
Summary: This study investigated the spatial stability of functional connectivity variations induced by parcellation errors. Using subjects from three public online datasets, the study simulated random parcellation variability and evaluated its effects on twenty-seven graph-theoretical measures. The results showed that certain measures had higher spatial stability while others had lower spatial stability. Multivariate analysis demonstrated significant effects of atlas, datasets, and thresholds. Additionally, spatial stability was influenced by threshold, atlas choice, and scanning parameters. The study highlights the importance of paying attention to parcellation-related spatial errors that may affect the reliability of functional connectivity measures.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Adrian Ponce-Alvarez, Morten L. Kringelbach, Gustavo Deco
Summary: Human fMRI and dMRI data were used to test the phenomenological renormalization group (PRG) method and found that the scale invariance of rs-fMRI activity may emerge from criticality and exponentially decaying connectivity between brain regions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Anees Abrol, Zening Fu, Yuhui Du, Tony W. W. Wilson, Yu-Ping Wang, Julia M. M. Stephen, Vince D. D. Calhoun
Summary: The brain's functional architecture and organization undergo continuous development and modification throughout adolescence. This study systematically evaluated over 47,000 youth and adult brains to examine time-resolved functional connectivity patterns and found distinct differences between the two life stages, indicating an overall inverted U-shaped trajectory in the strengthening and modularization of functional coupling. These findings suggest greater synchrony and integration of the brain's functional connections beyond adolescence, with a gradual decline during healthy aging.
HUMAN BRAIN MAPPING
(2023)
Article
Biology
Fan Wang, Han Zhang, Zhengwang Wu, Dan Hu, Zhen Zhou, Jessica B. Girault, Li Wang, Weili Lin, Gang Li
Summary: In this study, the authors developed the first set of infant-specific, fine-grained cortical functional parcellation maps using 1064 high-resolution longitudinal rs-fMRIs from 197 typically developing infants and toddlers. The cortical co-registration and alignment of functional connectivity maps allowed for the generation of over 800 fine-grained parcels, revealing complex functional developmental patterns in infant brains.
Article
Behavioral Sciences
Ayako Isato, Keita Yokokawa, Makoto Higuchi, Tetsuya Suhara, Makiko Yamada
Summary: This study found a positive association between individual differences in positive memory recollection and functional connectivity in the brain at rest. The frontotemporal network connectivity may have implications for vulnerability to stress and depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychology, Clinical
Lizhu Luo, Christelle Langley, Laura Moreno-Lopez, Keith Kendrick, David K. Menon, Emmanuel A. Stamatakis, Barbara J. Sahakian
Summary: This study examined the association between depressive symptoms in traumatic brain injury (TBI) patients and altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. The results showed a positive association between depression scores and rs-fc between limbic regions and cognitive control regions, while there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. These findings contribute to a better understanding of the mechanisms underlying depression following TBI and can inform treatment decisions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Behavioral Sciences
Zhihao Zhu, Hongwei Wang, Hui Bi, Jidong Lv, Xiaotong Zhang, Suhong Wang, Ling Zou
Summary: This study investigates the dynamic changes in brain networks of ADHD patients using resting-state fMRI data. The results show abnormal increases in mean dwell time and fraction of time spent in a specific state for ADHD patients. Correlations between different brain networks are weaker in ADHD patients compared to typically developing children.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Marlena Duda, Danai Koutra, Chandra Sripada
Summary: This study investigates the presence of dynamic functional connectivity during rest and proposes a data-driven framework for studying cognitive neuroscience questions using connectivity changes. The framework outperforms the traditional sliding window approach in accuracy and computational efficiency when applied to working memory task data. Additionally, when applied to resting state fMRI data, the method consistently identifies five reliable FC states which show significant correlation with behavioral phenotypes.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Jiang Zhang, Hongjie Cui, Huadong Yang, Yuanyuan Li, Dundi Xu, Tianyu Zhao, Huawang Wu, Zhengcong Du, Wei Huang, Chong Wang, Ai Chen, Jiaojian Wang
Summary: This study utilized sliding window method and litekmeans algorithm to investigate the dynamic functional network connectivity in MDD, revealing increased mean dwell time and correlation with depression symptom load in state #5, as well as significantly reduced FNC within FPN in state #7 for MDD patients compared to healthy controls. This new approach of determining optimal window length and number of clusters may facilitate future studies on functional dynamics and provide new evidence to better understand the neuropathology of MDD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Roni Setton, Laetitia Mwilambwe-Tshilobo, Manesh Girn, Amber W. Lockrow, Giulia Baracchini, Colleen Hughes, Alexander J. Lowe, Benjamin N. Cassidy, Jian Li, Wen-Ming Luh, Danilo Bzdok, Richard M. Leahy, Tian Ge, Daniel S. Margulies, Bratislav Misic, Boris C. Bernhardt, W. Dale Stevens, Felipe De Brigard, Prantik Kundu, Gary R. Turner, R. Nathan Spreng
Summary: The functional organization of the brain changes with age, with observed differences at multiple spatial scales. Older adults show global network dedifferentiation and network-specific patterns of dedifferentiation, suggesting changes in brain function with age.