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A review on gut microbiota: a central factor in the pathophysiology of obesity

LIPIDS IN HEALTH AND DISEASE (2021)

期刊

LIPIDS IN HEALTH AND DISEASE

卷 20, 期 1, 页码 -

出版社

BMC

DOI: 10.1186/s12944-021-01491-z

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Gut microbiota; Obesity; Metabolic syndrome; Faecal microbiota transplant

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Biochemistry & Molecular Biology Nutrition & Dietetics

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Obesity and gut microbiota have complex relationships, with microbiota playing a crucial role in influencing host health. Research into the contribution of gut microbiota towards host pathophysiology is leading to the development of new therapeutic methods to address the global obesity epidemic.

Obesity and its complications constitute a substantial burden. Considerable published research describes the novel relationships between obesity and gut microbiota communities. It is becoming evident that microbiota behave in a pivotal role in their ability to influence homeostatic mechanisms either to the benefit or detriment of host health, the extent of which is not fully understood. A greater understanding of the contribution of gut microbiota towards host pathophysiology is revealing new therapeutic avenues to tackle the global obesity epidemic. This review focuses on causal relationships and associations with obesity, proposed central mechanisms encouraging the development of obesity and promising prospective methods for microbiota manipulation.

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