Review
Nutrition & Dietetics
Jasmine Carter, Jeffery Bettag, Sylvia Morfin, Chandrashekhara Manithody, Aakash Nagarapu, Aditya Jain, Hala Nazzal, Sai Prem, Meghan Unes, Matthew McHale, Chien-Jung Lin, Chelsea Hutchinson, Grace Trello, Arti Jain, Edward Portz, Arun Verma, Marzena Swiderska-Syn, Daniel Goldenberg, Kento Kurashima
Summary: Short bowel syndrome (SBS) is a condition caused by a reduction in the length or functional capacity of the intestine. The gut microbiome plays a significant role in modulating disease progression in SBS patients. The composition and shifts of gut bacteria in SBS and the resulting systemic effects have been extensively studied, revealing the variability and dependence on multiple factors. The bidirectional communication between the gut and the brain, regulated by the microbiome, known as the gut-brain axis (GBA), also has implications in SBS.
Review
Geriatrics & Gerontology
Emily M. Klann, Upuli Dissanayake, Anjela Gurrala, Matthew Farrer, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Volker Mai, Vinata Vedam-Mai
Summary: Parkinson's disease is a chronic neurodegenerative disease characterized by the accumulation of misfolded alpha-synuclein protein in certain neurons. Recent research suggests a potential relationship between gut bacteria and the brain, known as the microbiome-gut-brain axis, which may play a role in the development of Parkinson's disease. This review provides an overview of the current knowledge on the relationship between gut microbiota and Parkinson's disease, discussing the role of alpha-synuclein and potential interventions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Environmental Sciences
Yi Huang, Yuhang Hong, Shu Wu, Xiaozhen Yang, Qiang Huang, Yanzhen Dong, Dayong Xu, Zhiqiu Huang
Summary: The present study investigated the toxic effects of IMI on the brain and gut of zebrafish by analyzing the transcriptome and microbiome. The results showed that prolonged darkness improved survival rate and attenuated oxidative stress induced by IMI exposure. Microbiome analysis also revealed changes in gut bacterial community structure and tryptophan metabolism pathway inhibition, which were alleviated in the prolonged darkness group.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Leyla Nazarova, Hong Liu, Hongrong Xie, Lufeng Wang, Hao Ding, Hedi An, Dongya Huang
Summary: The study suggests that targeting the gut-brain axis through electroacupuncture in early stages of Parkinson's disease may be an effective therapeutic option for managing both non-motor and motor symptoms. The results showed improvement in various clinical scales and significant alterations in gut bacterial composition after the treatment.
Review
Pharmacology & Pharmacy
Amer H. Asseri, Tahani Bakhsh, Samah Sulaiman Abuzahrah, Sajad Ali, Irfan A. Rather
Summary: The human gut microbiota consists of over 100 trillion organisms, mainly bacteria, outnumbering the host body cells by a factor of ten. The gastrointestinal tract, housing a large number of immune cells, plays a crucial role in maintaining immune homeostasis. However, dysbiosis of the gut microbiota can lead to inflammation and tumorigenesis. This review explores the impact of gut microbiota dysbiosis on cancer development and discusses the potential of manipulating the gut microbiota for cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Aditya Enjeti, Harindra Darshana Sathkumara, Andreas Kupz
Summary: Tuberculosis (TB) has been a global infectious disease problem for a long time. Efforts to eliminate TB have been hindered by factors such as the complexity of Mycobacterium tuberculosis (Mtb), the emergence of antibiotic resistant strains, and the impact of the COVID-19 pandemic. Studying the immunomodulatory role of gastrointestinal microbiota offers a new direction for TB research.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Daniela Ratto, Elisa Roda, Marcello Romeo, Maria Teresa Venuti, Anthea Desiderio, Giuseppe Lupo, Enrica Capelli, Anna Sandionigi, Paola Rossi
Summary: This study investigated the effects of physiological aging on gut microbiome composition and the relationship between cognitive frailty and gut microbiome composition. The results showed that physiological aging significantly affected the overall gut microbiome composition and the relative abundance of specific bacterial taxa. Additionally, several amplicon sequence variants were found to be significantly associated with the Cognitive Frailty Index.
Editorial Material
Microbiology
Marc D. Cook, Taylor Hogue
Summary: This article aims to explore the mechanisms of how exercise affects gut microbial characteristics and vascular health outcomes, as well as provide insights into future research directions.
Review
Biochemistry & Molecular Biology
Jamie van Son, Laura L. Koekkoek, Susanne E. La Fleur, Mireille J. Serlie, Max Nieuwdorp
Summary: Obesity, a global epidemic, is associated with microbial dysbiosis. Research indicates that the gut microbiota and its metabolites have an impact on human brain and behavior. Future treatment strategies for obesity may target the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Pedram Honarpisheh, Robert M. Bryan, Louise D. McCullough
Summary: The microbiota-gut-brain-axis (MGBA) is a communication network between gut microbes and the host, and dysbiosis disrupts this network, affecting the host's immune, metabolic, and nervous systems. Dysbiosis is linked to aging and stroke, and is associated with stroke risk factors such as obesity and diabetes. The article summarizes the role of MGBA signaling in the development of stroke risk factors and discusses current understanding of microbiota-based therapies for stroke.
CIRCULATION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Ling Li, Jiahui Yang, Tianjing Liu, Yongyan Shi
Summary: Brain injury is a common complication in preterm infants, causing destruction of brain connections and leading to neurodevelopmental disorders with high morbidity and mortality rates. The role of intestinal flora in brain development and immune maturation in infants is important, but the understanding of the gut microbiota-metabolite-brain axis in preterm infants is limited. This review summarizes the mechanisms by which intestinal microbiota contribute to neurodevelopment and brain injury in preterm infants, emphasizing the influence of microorganisms and metabolites on neurocognitive development and neurodevelopmental risks associated with preterm birth, infection, and NEC. The review supports the development and application of therapeutic strategies such as probiotics, prebiotics, synbiotics, and fecal bacteria transplantation for brain injury in preterm infants.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Review
Cell Biology
Mohammed A. S. Khan, Sulie L. Chang
Summary: Binge or chronic alcohol consumption causes neuroinflammation and leads to alcohol use disorder (AUD). Growing evidence shows that excessive alcohol consumption can activate neuroimmune cells, including microglia, and change the status of neurotransmitters, affecting the neuroimmune system.
Review
Cell Biology
Qinwen Wang, Qianyue Yang, Xingyin Liu
Summary: The gut microbiota interacts with the brain through the microbiota-gut-brain axis, regulating physiological processes and impacting neurodevelopmental disorders. Researchers have identified three pathways through which the gut microbiota regulates neurodevelopment: the immune pathway, the neuronal pathway, and the endocrine/systemic pathway. This review provides an overview of research advancements in the microbiota-gut-brain axis in neurodevelopmental disorders and discusses the current state and future perspectives in this field.
Review
Nutrition & Dietetics
Eleuterio A. Sanchez Romero, Erika Melendez Oliva, Jose Luis Alonso Perez, Sebastian Martin Perez, Silvia Turroni, Lorenzo Marchese, Jorge Hugo Villafane
Summary: This study aimed to review the association between gut microbiome and pain in OA patients and found only three out of 2084 studies supported a relationship, but the results were not conclusive. It also highlighted the lack of high-quality studies and significant technique disparities, making it impossible to draw firm conclusions on the topic.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.