Article
Biology
Qiuying Liu, Xiaoli Chen, Mariah K. Novak, Shaojie Zhang, Wenqian Hu
Summary: Research shows that Trim71 represses Ago2 mRNA translation in mouse embryonic stem cells, which leads to an increase in mature let-7 microRNAs and affects stemness and differentiation. This highlights the importance of repressing the prodifferentiation let-7 microRNAs for maintaining pluripotency.
Review
Biochemistry & Molecular Biology
David L. Bernstein, Xinpei Jiang, Slava Rom
Summary: The let-7 family of microRNAs is highly expressed in the cerebral and cardiovascular systems, and plays a role in cardiovascular diseases and associated inflammation. It is involved in the development and differentiation of embryonic stem cells in the cardiovascular system, and may serve as a research focus for potential therapeutic targets in cardiovascular diseases.
Review
Health Care Sciences & Services
Fabrice Duval
Summary: So far, neuroendocrine studies conducted in schizophrenic patients have yielded conflicting results due to various influencing factors, population heterogeneity, lack of test standardization, and previous treatments effects. Apomorphine (APO) has been widely used in evaluating dopaminergic (DA) function by indirectly assessing the functionality of DA receptors at the hypothalamic-pituitary level. This review provides an update on the applications of the APO test in schizophrenia in clinical, pathophysiological, and therapeutic fields.
Review
Peripheral Vascular Disease
Nicholas Yozamp, Gregory L. Hundemer, Marwan Moussa, Jonathan Underhill, Tali Fudim, Barry Sacks, Anand Vaidya
Summary: ACTH stimulation during adrenal venous sampling for primary aldosteronism can improve successful catheterization rates but may lead to decreased lateralization rates and potentially underestimate surgically remediable disease. Studies over the past 5 years have shown approximately 25% discordance in lateralization rates between unstimulated and stimulated sampling. The role of ACTH should primarily be limited to enhancing selectivity during adrenal venous sampling.
Review
Medicine, General & Internal
Mohammad Rezai, Catherine Fullwood, Beverly Hird, Meghna Chawla, Lesley Tetlow, Indraneel Banerjee, Leena Patel
Summary: This systematic review examined endogenous cortisol levels in children and adolescents during acute illnesses and found that these levels were higher than those in controls and varied across different acute diseases. This has important implications for optimizing glucocorticoid stress doses for children and adolescents with glucocorticoid deficiency.
Review
Oncology
Truman Knowles, Tina Huang, Jin Qi, Shejuan An, Noah Burket, Scott Cooper, Javad Nazarian, Amanda M. Saratsis
Summary: Diffuse midline glioma (DMG) is a devastating pediatric brain tumor with an urgent need for new treatment options. LIN28B RNA binding protein is overexpressed in DMG and suppresses the let-7 family of microRNAs, which in turn suppress a multitude of oncogenes. This review summarizes the role of the LIN28B-let-7-oncogene axis in different glioma subtypes and recommends future research focusing on DMG as a potential therapeutic target.
Article
Biology
Andrei Marian Niculae, Maria Dobre, Vlad Herlea, Teodora Ecaterina Manuc, Bogdan Trandafir, Elena Milanesi, Mihail Eugen Hinescu
Summary: Increased activity of the insulin-like growth factor (IGF) axis is associated with the development and progression of colorectal cancer (CRC). The let-7 family of microRNAs (miRNAs) has been shown to target genes involved in the IGF signaling pathway and function as tumor suppressors. This study found that multiple let-7 miRNAs were down-regulated in CRC tissues, and that specific dysregulation of let-7 miRNAs was observed in CRC with perineural invasion. These findings suggest a relationship between the IGF axis, let-7 miRNAs, and CRC, as well as an association between the expression of these miRNAs and perineural invasion.
Review
Endocrinology & Metabolism
Xiaofang Zhang, Dihua Huang, Xiaojie Pan, Qiya Si, Qiaoying You
Summary: Ectopic adrenocorticotropic hormone syndrome (EAS) is a rare condition of hypercortisolism caused by non-pituitary tumors that secrete adrenocorticotropic hormone (ACTH). This study reports a case of an aggressive ACTH-producing gallbladder malignancy with liver metastases, confirmed by pathological and immunohistochemical analysis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Yutaka Watanuki, Kanako Niioka, Makoto Daimon
Summary: The hypothalamic-pituitary-adrenal axis is stimulated in response to stress, and glucocorticoids regulate its activity by inhibiting Pomc gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Asghar Ali, Muhammad A. Iqbal, Muhammad W. Abbas, Gerrit J. Bouma, Russell Anthony, Thomas E. Spencer, Quinton A. Winger
Summary: In this study, transcriptome analysis revealed the potential roles of the LIN28-let-7 axis in placental and fetal development in ruminants, beyond its involvement in trophoblast proliferation and conceptus elongation.
Review
Endocrinology & Metabolism
Daniele Cavaleri, Chiara Alessandra Capogrosso, Pierluca Guzzi, Gianna Bernasconi, Martina Re, Blazej Misiak, Cristina Crocamo, Francesco Bartoli, Giuseppe Carra
Summary: This study investigated the differences in blood concentrations of anterior pituitary hormones between drug-naive individuals with first-episode psychosis and healthy controls. The results showed that drug-naive individuals with first-episode psychosis had higher levels of ACTH and PRL, and lower levels of TSH compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Cell Biology
Yuxi Ma, Na Shen, Max S. Wicha, Ming Luo
Summary: Cancer stem-like cells play a critical role in tumorigenesis, cancer progression, treatment resistance, and metastatic relapse. The let-7 family of microRNAs is important in regulating cancer stemness through various RNA-binding proteins, long non-coding RNAs, and circular RNAs. Targeting let-7 for cancer therapeutics has the potential to improve treatment efficacy by specifically targeting CSCs and modulating metabolic pathways.
Article
Clinical Neurology
Alexandros N. Vgontzas, Julio Fernandez-Mendoza, Kristina Puzino Lenker, Maria Basta, Edward O. Bixler, George P. Chrousos
Summary: Insomnia, especially when associated with objective sleep disturbance, was found to be related to activation of the hypothalamic-pituitary-adrenal axis. Men with insomnia demonstrated shorter total sleep time and lower sleep efficiency on polysomnography, as well as lower levels of adrenocorticotropic hormone and cortisol after exposure to stress, suggesting a disrupted hypothalamic-pituitary-adrenal axis function in this population.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Oncology
Hao Chen, Jiewei Wang, Huan Wang, Jingru Liang, Jinhua Dong, Houqiao Bai, Guosheng Jiang
Summary: The Let-7 family of miRNAs plays a crucial role in various biological processes and is associated with tumor occurrence and prognosis. Let-7 is not only a potential diagnostic and prognostic marker for leukemia, but also a potential therapeutic target.
Article
Medical Laboratory Technology
Jacquelien J. Hillebrand, Li Zhou, Marilee A. Marcinkus, Maria Datwyler, Susan H. Gawel, Frans Martens, Gerard J. Davis, Annemieke C. Heijboer
Summary: This study investigated the long-term storage stability of corticotropin in plasma. The results showed that corticotropin levels remained stable when stored at -20 degrees C for one and a half years, but a significant reduction was observed in patient samples stored for up to 6 years at the same temperature.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
