Article
Nutrition & Dietetics
Grazyna Swiderska-Kolacz, Malgorzata Jefimow, Jolanta Klusek, Norbert Raczka, Szymon Zmorzynski, Anna Wojciechowska, Iwona Stanislawska, Marek Lyp, Joanna Czerwik-Marcinkowska
Summary: This study found that diet supplementation with Pinnularia borealis could lower cholesterol and triacylglycerol concentrations in the liver and kidneys of mice, indicating the protective properties of algae. Additionally, even a low concentration of Pinnularia borealis was sufficient to improve antioxidant capacity.
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Una Glamoclija, Fulden Ulucan-Karnak, Sara Redensek Trampuz, Vita Dolzan
Summary: This article highlights the critical role of oxidative stress in COVID-19, discussing genetic variants within the oxidative stress pathway associated with the disease and exploring the use of antioxidant therapies in clinical trials for COVID-19 treatment, particularly glutathione and N-acetylcysteine.
Article
Chemistry, Medicinal
Marlena Brzozowa-Zasada, Adam Piecuch, Karolina Bajdak-Rusinek, Kamil Janelt, Marek Michalski, Olesya Klymenko, Natalia Matysiak
Summary: Studies have shown that the expression of Gpx-1 is associated with cancer development and its role in regulating reactive oxygen species levels. This study aimed to investigate the expression of Gpx-1 in colon adenocarcinoma patients in Poland. Immunohistochemical analysis revealed that high expression of Gpx-1 was associated with tumor grade, PCNA expression, invasion depth, and angioinvasion (all p < 0.001). High expression of Gpx-1 was correlated with poor prognosis in colon adenocarcinoma patients.
Article
Environmental Sciences
Khadija Sossey Alaoui, Bernard Tychon, Sandrine Joachim, Alain Geffard, Katherine Nott, Sebastien Ronkart, Jean-Marc Porcher, Remy Beaudouin, Christelle Robert, Marie-Laure Fauconnier, Matthew Saive
Summary: The study aimed to assess the toxicity of a mixture of five pharmaceutical drugs using Fontinalis antipyretica as a bioindicator and bioaccumulator. Results showed that only carbamazepine and irbesartan were accumulated by the species, with bioaccumulation levels increasing with exposure time. Antioxidant enzymes were sensitive to the drug mixture, with higher activity observed in plants exposed to higher concentrations. Chlorophyll content decreased in exposed plants, but photosynthetic activity was restored after 5 months. Morphological characteristics were less impacted by the treatment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Medicine, Research & Experimental
Puja Ghosh, Rosaria Anna Fontanella, Lucia Scisciola, Ada Pesapane, Fatemeh Taktaz, Martina Franzese, Armando Puocci, Antonio Ceriello, Francesco Prattichizzo, Maria Rosaria Rizzo, Giuseppe Paolisso, Michelangela Barbieri
Summary: Reactive oxygen species (ROS) play important roles in regulating various cellular processes and can impact cell survival, death, inflammation, differentiation, growth, and immune response. Pathological conditions like diabetes can increase ROS production, leading to protein and DNA damage, neurodegeneration, and cognitive decline. GLP-1RAs, a type of anti-diabetic drug, have been found to reduce ROS generation and improve cognitive function.
Article
Chemistry, Multidisciplinary
Rosa Martha Perez-Gutierrez, Isis Sherazada Rodriguez-Clavel, Silvia Patricia Paredes-Carrera, Jesus Carlos Sanchez-Ochoa, Alethia Muniz-Ramirez, Susanna Medellin Garibay, Eri Joel Paz-Garcia
Summary: This study identified flavonols from Vaccinium macrocarpon through HPLC-MS, and prepared nanoparticles using highly crosslinked keratin and silver. The nanocomposites were found to protect rat INS-1 pancreatic beta-cells from H2O2-induced oxidative damage, apoptosis, and proliferation by reducing intracellular reactive oxygen species.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Summary: This study compared the changes in oxidative stress and GSH-related antioxidant capacities before and after tumor resection in HCC patients, showing a decrease in plasma malondialdehyde level and varying increases in GSH and related enzyme activities. The findings suggest a potential therapeutic use of GPx or GR as targets for reducing HCC recurrence.
Article
Pharmacology & Pharmacy
Wenbin Wu, Qingsong Xia, Yujin Guo, Hongzhan Wang, Hui Dong, Fuer Lu, Fen Yuan
Summary: This study confirmed that berberine can promote the secretion of GLP-1 in intestinal L cells and islet alpha cells through activation of the GLP-1/GLP-1R/PKA signaling pathway, thus improving the function of islet beta cells and treating T2DM.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Megan E. Solan, Camryn P. Koperski, Sanjanaa Senthilkumar, Ramon Lavado
Summary: This study investigates the effects of five short-chain PFAS compounds on oxidative stress biomarkers in vitro, finding that all short-chain PFAS compounds except for PFHxS increase the activity of at least one antioxidant enzyme.
ENVIRONMENTAL RESEARCH
(2023)
Article
Plant Sciences
Naznin Ahmed, Khussboo Rahman, Mira Rahman, Khadeja Sultana Sathi, Md Mahabub Alam, Kamrun Nahar, Md Shahidul Islam, Mirza Hasanuzzaman
Summary: The bioregulator thiourea is effective in mitigating the negative impact of abiotic stresses on plants. This study found that thiourea application improved growth, oxidative stress tolerance, and protection of photosynthetic pigments in chickpea plants under drought stress.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Piotr Rozentryt, Sylwia Duda, Mariusz Gasior, Celina Wojciechowska
Summary: This study found a correlation between ceruloplasmin levels and various biomarkers in patients with HFrEF, suggesting ceruloplasmin's potential as a useful biomarker in this population. Ceruloplasmin was positively correlated with cardiac and hepatic status, inflammatory markers, and oxidative stress indicators. These results provide new insights for classification and treatment strategies for HFrEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Domenico Lapenna
Summary: Glutathione (GSH) is an important low-molecular weight thiol nucleophile and reductant with multiple functions, including antioxidant protection, detoxification, and cell signaling. It works in concert with GSH-dependent enzymes and its levels decline during aging, although elevated GSH levels in elderly individuals with good health suggest a potential link to increased healthspan and lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Nutrition & Dietetics
Hai Jia, Yunchang Zhang, Xuemeng Si, Yuhang Jin, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: This study demonstrates that quercetin can alleviate diquat-induced cell injury in enterocytes by upregulating the protein abundance of Nrf2 and regulating GSH-related redox homeostasis.
Article
Biochemistry & Molecular Biology
Han-Mei Du, Chan Liu, Xin-Wu Jin, Cheng-Feng Du, Yan Yu, Shuai Luo, Wen-Zhu He, Su-Zhi Zhang
Summary: Aluminum (Al) toxicity is a major constraint for plant growth and cereal crop yield in acidic soils. This study identified a maize ALDH gene, ZmALDH, which is involved in protection against Al-induced oxidative stress. Overexpression of ZmALDH in Arabidopsis increased Al tolerance by promoting antioxidant mechanisms and reducing Al accumulation in roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natacha E. Piloni, Romina Vargas, Virginia Fernandez, Luis A. Videla, Susana Puntarulo
Summary: Acute iron overload in rat brain induces oxidative stress, depletion of glutathione, and increased lipid peroxidation, which leads to the upregulation of Nrf2-mediated antioxidant regulation. This protective adaptive response is characterized by the elevation of GPx, GPx-Se, and GST protein expression. Further studies are needed to fully understand the intricate network of processes involved in maintaining GSH functions and the mechanisms triggered by iron overload in the brain.
Review
Food Science & Technology
Sonia Ramos, Maria Angeles Martin
Summary: Human gut microbiota (GM) can be influenced by diet, which in turn can impact human health. Research has shifted from studying individual dietary components to overall dietary patterns in relation to GM. This review summarizes recent advances in understanding the influence of food components and dietary patterns on GM and human health.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Chemistry, Applied
Federica Moccia, Maria Angeles Martin, Sonia Ramos, Luis Goya, Stefania Marzorati, Marina DellaGreca, Lucia Panzella, Alessandra Napolitano
Summary: A red pigment was successfully prepared by the reaction of chlorogenic acid and tryptophan, which showed intense coloring effects on various food matrices and good stability. It exhibited non-toxicity to hepatic and colonic cell lines at a certain concentration, indicating its potential as an alternative red coloring agent for food products.
Review
Food Science & Technology
Maria Angeles Martin, Sonia Ramos
Summary: The review summarizes human studies from the past two decades, indicating the potential beneficial effects of cocoa consumption on health and chronic diseases. However, the outcomes are not unequivocal, and the mechanisms of action are not fully understood. It remains unclear whether cocoa consumption should be recommended, and what is the appropriate dosage or duration.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Alicia Caro-Vadillo, Francisco Perez-Vizcaino, Jara Perez-Jimenez, Sonia Ramos, Maria Angeles Martin
Summary: Diabetic cardiomyopathy is a major cause of death among diabetic patients. Oxidative stress and inflammation play key roles in its development. Dietary flavonoids have strong antioxidant and anti-inflammatory activities, and their combination with antidiabetic drugs has potential benefits. This study found that a cocoa-carob blend diet, rich in flavonoids, can prevent cardiac remodeling and dysfunction in diabetic animals, and its effects are further improved when used in combination with metformin.
Article
Food Science & Technology
Esther Garcia-Diez, Helena Senchez-Ayora, Maria Blanch, Sonia Ramos, Maria Angeles Martin, Jara Perez-Jimenez
Summary: Evidence suggests that combining carob with cocoa can result in a blend with high dietary fiber, methylxanthines, and polyphenols, and less bitterness compared to pure cocoa. This blend may serve as a suitable alternative to commercial sugar-rich soluble cocoa powders.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Elisa Fernandez-Millan, Sonia Ramos, David Alvarez-Cilleros, Sara Samino, Nuria Amigo, Xavier Correig, Monica Chagoyen, Carmen Alvarez, Maria Angeles Martin
Summary: This study used metabolomics tools to investigate the metabolic impact of cocoa in type 2 diabetes. The results showed that cocoa supplementation decreased blood glucose levels, improved glucose metabolism, and produced significant changes in urinary metabolites. Pathway analysis revealed the involvement of branched-chain amino acids and ketone bodies in the beneficial impact of cocoa on diabetes.
Article
Nutrition & Dietetics
Paula Martinez-Oca, Claudio Alba, Alicia Sanchez-Roncero, Tamara Fernandez-Marcelo, Maria Angeles Martin, Fernando Escriva, Juan Miguel Rodriguez, Carmen Alvarez, Elisa Fernandez-Millan
Summary: This study suggests that maternal malnutrition during lactation can impact the microbial composition of mother's milk and offspring gut colonization. These microbial changes compromise the correlations between milk and fecal samples and lead to increased offspring gut permeability and altered expression of goblet cell markers.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Francisco Perez-Vizcaino, Jara Perez-Jimenez, Sonia Ramos, Maria Angeles Martin
Summary: In this study, it was shown that a cocoa-carob blend rich in polyphenols improved gut health and gut microbiota composition in diabetic rats. The blend regulated the levels of mucin and tight-junction proteins, reduced oxidative stress and inflammation, and modulated the composition of gut bacteria. Several phenolic metabolites in the blend were found to be associated with specific changes in gut bacteria composition.
Article
Biochemistry & Molecular Biology
Esther Garcia-Diez, Maria Elvira Lopez-Oliva, Jara Perez-Jimenez, Maria Angeles Martin, Sonia Ramos
Summary: This study demonstrates that epicatechin and 2,3-dihydroxybenzoic acid can modulate energy metabolism and insulin signaling in cardiac cells through the activation of AKT and AMPK pathways.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)