Article
Pharmacology & Pharmacy
Tokiko Suzuki, Shigeyuki Yamashita, Kohshi Hattori, Naoyuki Matsuda, Yuichi Hattori
Summary: The study demonstrated that long-term exposure to high glucose can enhance activation of NF-kappa B in LPS-stimulated macrophages possibly due to excessive ROS production, leading to increased macrophage pro-inflammatory responses.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Klosek, Agnieszka Krawczyk-Lebek, Edyta Kostrzewa-Suslow, Ewelina Szliszka, Joanna Bronikowska, Dagmara Jaworska, Grazyna Pietsz, Zenon P. Czuba
Summary: Inflammation plays a crucial role in immune defense, but chronic inflammation may lead to neurodegenerative diseases, atherosclerosis, inflammatory bowel diseases, or cancer. Flavanones found in citrus fruits possess anti-oxidative and anti-inflammatory properties. This study demonstrates that methyl derivatives of flavanone can inhibit inflammation and modulate the production of inflammatory cytokines.
Article
Food Science & Technology
Eun Hae Kim, Youn Young Shim, Hye In Lee, Sanghyun Lee, Martin J. T. Reaney, Mi Ja Chung
Summary: The current study found that astragalin and isoquercitrin from chamchwi had anti-neuroinflammatory effects by inhibiting the MAPK signaling pathway. Astragalin and isoquercitrin reduced the inflammatory response in LPS-induced microglial cells and hippocampus in mice.
Article
Biochemistry & Molecular Biology
G. L. Shyni, J. Renjitha, Sasidhar B. Somappa, K. G. Raghu
Summary: The study demonstrated that Zerumin A (ZA) effectively protected cardiomyocytes from LPS-induced inflammation by inhibiting NF-kB p65 activation via the MAPK signaling pathway. ZA showed modulation effects on both pro-inflammatory and anti-inflammatory cytokines, suggesting its potential as a promising agent for the treatment of myocardial dysfunction in sepsis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Behavioral Sciences
Kathryn A. McNaughton, Lauren L. Williamson
Summary: In learning and memory tasks, immune activation plays a role in performance. Peripheral immune stimulation impairs context-object discrimination memory in male rats, but its effects on females and the potential for rescue are unclear. Male rats showed memory impairment in response to immune stimulation, whereas female rats did not. Treatment with IL-1ra improved memory in females, but not in males. Specific cytokine signals may be altered in impaired males. Understanding sex differences in response to inflammatory challenges is important for understanding memory impairments.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jaqueline Pereira Moura Soares, Diego Assis Goncalves, Ricardo Xisto de Sousa, Margareth Gori Mouro, Elisa M. S. Higa, Leticia Paulino Sperandio, Carolina Moraes Vitoriano, Elisa Bachir Santa Rosa, Fernanda Oliveira dos Santos, Gustavo Nery de Queiroz, Roberta Sessa Stilhano Yamaguchi, Gustavo Pereira, Marcelo Yudi Icimoto, Fabiana Henriques Machado de Melo
Summary: Cutaneous melanoma is the most aggressive type of skin cancer, and it progresses through different stages. Reactive oxygen species modulate oncogenic signaling pathways in all stages of melanoma development. The altered concentration of tetrahydrobiopterin disrupts cellular redox homeostasis and contributes to melanoma progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yasuo Ito, Harumitsu Nagoya, Masamizu Yamazato, Yoshio Asano, Masahiko Sawada, Tomokazu Shimazu, Makiko Hirayama, Toshimasa Yamamoto, Nobuo Araki
Summary: This study investigated the effects of aging on nitric oxide (NO) production during cerebral ischemia-reperfusion (IR). The results showed that the change in NO3- levels in the plasma of older rats was lower compared to younger rats during cerebral ischemia-reperfusion. Hypertension and aging may be important factors impacting NO production in brain IR injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ting Li, Zhiyong Liu, Jinglei Hu, Lin Chen, Tiantian Chen, Qianqian Tang, Bixia Yu, Bo Zhao, Chun Mao, Mimi Wan
Summary: A zwitterion-based artificial chemotactic nanomotor is proposed for precise targeting in vivo, utilizing high levels of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) as chemoattractants. The chemotactic behavior of the nanomotors is evaluated through static models, dynamic models, in vivo models, and mesoscale hydrodynamics simulations. This chemotactic delivery strategy has the potential to improve delivery efficiency and be applicable to various inflammatory diseases.
ADVANCED MATERIALS
(2022)
Article
Fisheries
Seung-Hyeon Kim, Ki-Woong Nam, Bassem Allam, Kwang-sik Choi, Kwan-Ha Park, Kyung-Il Park
Summary: The study investigated changes in nitric oxide (NO) levels, cyclooxygenase 2 (COX-2) activity, and allograft inflammatory factor-1 (AIF-1) gene expression levels in hemolymph samples collected from Manila clam exposed to pro- and anti-inflammatory substances. The results suggest that the mechanism of inflammatory responses in bivalves is very similar to that of vertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
Summary: Ferulic acid and its metabolites show efficacy in combating inflammation by limiting the expression and activity of proinflammatory enzymes, reducing NF-κB translocation, and promoting Nrf2 expression.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Erica Costantini, Srinivas Jarlapoodi, Federica Serra, Lisa Aielli, Haroon Khan, Tarun Belwal, Katia Falasca, Marcella Reale
Summary: This study evaluates the anti-inflammatory and regenerative properties of Bacopa monnieri extract (BME) in an in vitro model of neuroinflammation. The results show that BME protects neuronal cells from cytotoxicity and reduces the expression of inflammatory genes, while accelerating wound healing. Therefore, BME may be a promising candidate for the treatment of neuroinflammation.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Chemistry, Medicinal
Maryam Akhtar, Jiabin Niu, Yujie Zhu, Zhaoyi Luo, Ting Tian, Yuanliang Dong, Yuan Wang, Muhammad Subaan Fareed, Li Lin
Summary: In this study, a combination of design, synthesis, computational study, in-vitro screening, and in-vivo evaluation was used to accelerate the discovery of anti-inflammatory drugs. The newly synthesized compounds exhibited strong dose-dependent inhibitory effects on nitric oxide (NO) release, with no obvious cytotoxicity. Several model compounds (7a, 7b, 7d, 7f, and 7g) showed promising anti-inflammatory activity in the in-vitro assay, with IC50 values ranging from 20.76 mu M to 47.8 mu M. Furthermore, these compounds demonstrated inhibition of ear edema in mice, indicating their potential as anti-inflammatory agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Paola Montes, Ana Guerra-Librero, Paloma Garcia, Maria Elena Cornejo-Calvo, Maria del Senor Lopez, Tomas de Haro, Laura Martinez-Ruiz, Germaine Escames, Dario Acuna-Castroviejo
Summary: This study investigated the impact of the hypomethylating agent 5-azacitidine on the redox status and inflammation in MDS patients. The results showed that MDS patients had a lower redox status and higher CAT activity compared to healthy subjects. The progression of the disease was associated with increased GPx activity, GSSG/GSH ratio, LPO, and AOPP levels, and decreased CAT activity. The study also found changes in pro-inflammatory cytokines and plasma nitrite plus nitrate levels, but no association between inflammation and oxidative stress was observed.
Article
Multidisciplinary Sciences
Kundan Solanki, Sajjan Rajpoot, Evgeny E. Bezsonov, Alexander N. Orekhov, Rohit Saluja, Anita Wary, Cassondra Axen, Kishore Wary, Mirza S. Baig
Summary: This article discusses the importance of nitric oxide synthases 1 (NOS1) and its byproduct nitric oxide (NO) in different tissues and diseases, highlighting the significance of understanding NOS1-derived NO signaling and identification of NO-metabolites for disease diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Jereme G. Spiers, Natasha Steiger, Arun Khadka, Juliani Juliani, Andrew F. Hill, Nickolas A. Lavidis, Stephen T. Anderson, Hsiao-Jou Cortina Chen
Summary: Bidirectional communication between the neuroendocrine stress and immune systems allows glucocorticoids to exert pro-inflammatory effects, leading to a preferential induction of a pro-inflammatory response in the liver. Stress also increases levels of active vitamin D and causes sustained liver damage.
Article
Neurosciences
Steven J. Granger, Laura M. Glynn, Curt A. Sandman, Steven L. Small, Andre Obenaus, David B. Keator, Tallie Z. Baram, Hal Stern, Michael A. Yassa, Elysia Poggi Davis
Summary: Unpredictable maternal signals during infancy may affect the development of brain pathways, leading to aberrant cognitive and emotional outcomes. Studies have found that this maternal behavior pattern alters brain circuit maturation in animal models, but the association in humans is still uncertain.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Juliani Juliani, Natasha Vassileff, Jereme G. Spiers
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Julie-Myrtille Bourgognon, Jereme G. Spiers, Sue W. Robinson, Hannah Scheiblich, Paul Glynn, Catharine Ortori, Sophie J. Bradley, Andrew B. Tobin, Joern R. Steinert
Summary: The study demonstrated that pharmacological suppression of neuroinflammatory NO signaling could slow down neurodegenerative disease progression and reduce cellular stress associated with nitrosation and protein misfolding.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Jereme G. Spiers, Natasha Vassileff, Andrew F. Hill
Summary: Neuroinflammation involves coordinated responses from multiple cell types and cellular communication mechanisms. Extracellular vesicles (EVs) have emerged as important regulators of the inflammatory response, delivering selectively packaged proteins, miRNA, and lipids between different cells and tissues.
NEUROMOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jereme G. Spiers, Li Si Tan, Stephen T. Anderson, Andrew F. Hill, Nickolas A. Lavidis, Hsiao-Jou Cortina Chen
Summary: This study investigated the changes in essential metal homeostasis following exposure to short-term repeated stress in rats, revealing that stress can lead to hepatic redox imbalance and metal redistribution. Additionally, stress was found to modulate the mRNA levels of key metal transporters.
Review
Cell Biology
Arun Khadka, Jereme G. Spiers, Lesley Cheng, Andrew F. Hill
Summary: This review discusses the transmission and neurotoxicity mechanisms of prion diseases. The self-propagation of prion protein and intercellular communication through extracellular vesicles play important roles in disease progression. Understanding these transmission mechanisms is crucial for the development of therapies and discovery of biomarkers for prion diseases.
CELL AND TISSUE RESEARCH
(2023)
Article
Psychiatry
Emily J. Jaehne, Jessica N. Kent, Emily J. Antolasic, Bradley J. Wright, Jereme G. Spiers, Kerstin C. Creutzberg, Federico De Rosa, Marco A. Riva, Caryl E. Sortwell, Timothy J. Collier, Maarten van den Buuse
Summary: The BDNF Val66Met polymorphism, associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD, was found to impair fear memory in rats. This impairment was not dependent on animal sex or observed during adolescence, and there were no genotype differences in other types of memory.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Lina Schonfeld, Emily J. Jaehne, Alexandra R. Ogden, Jereme G. Spiers, Samuel Hogarth, Maarten van den Buuse
Summary: Adolescent stress and chronic abuse of methamphetamine have been compared in terms of dopaminergic behavioral sensitization in adulthood. The study found that chronic adolescent treatment with corticosterone reduced meth-induced locomotor hyperactivity in adulthood, while chronic meth treatment in adolescence enhanced meth hyperlocomotion. BDNF does not appear to be involved in these effects of chronic corticosterone or chronic meth.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Jereme G. Spiers, Hsiao-Jou Cortina Chen, Tiffany L. Barry, Julie-Myrtille Bourgognon, Joern R. Steinert
Summary: Neurodegenerative diseases are characterized by dysfunctional cellular pathways, with one major factor being redox stress during the development of protein misfolding conditions. In mice with prion disease, we identified an altered redox metal homeostasis and a pro-oxidant environment, which may contribute to the progression of the disease. Our findings suggest that oxidative stress and imbalanced metal regulation play important roles in the early pathology of protein misfolding diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Developmental Biology
Emily J. Jaehne, Jessica N. Kent, Nikki Lam, Lina Schonfeld, Jereme G. Spiers, Veronica Begni, Federico De Rosa, Marco A. Riva, Maarten van den Buuse
Summary: Exercise has been shown to be beneficial in reducing symptoms of affective disorders and increasing BDNF expression. This study found that rats that had access to running wheels during adolescence exhibited higher levels of anxiety and depression-like behaviors in adulthood, regardless of their BDNF Val66Met genotype.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Neurosciences
Wenting Zhao, Jereme G. Spiers, Natasha Vassileff, Arun Khadka, Emily J. Jaehne, Maarten van den Buuse, Andrew F. Hill
Summary: Small non-coding miRNA, such as miR-146a, play a key role in regulating physiological processes and inflammation. This study investigates the behavioral and neuroinflammatory phenotype of miR-146a knockout mice and reveals its importance in regulating inflammation and oxidative stress in the brain.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Microbiology
Jereme G. Spiers, Hsiao-Jou Cortina Chen, Joern R. Steinert
Summary: This article explores the pathogenesis and therapeutic approaches of transmissible spongiform encephalopathies caused by the misfolding and aggregation of PrPC protein. It suggests that an altered redox balance within the cell can lead to the formation and further aggregation of PrPSc, resulting in neuronal dysfunction and neuroinflammation. Therapeutic approaches targeting redox signaling are discussed.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)