Article
Biochemistry & Molecular Biology
Bugga Paramesha, Mohammed Soheb Anwar, Himanshu Meghwani, Subir Kumar Maulik, Sudheer Kumar Arava, Sanjay K. Banerjee
Summary: Activation of Sirt1 and Sirt3 improved cardiac structural and functional parameters in high fructose diet-induced insulin-resistant rats, by reducing insulin resistance, oxidative stress, and enhancing mitochondrial function. However, there was no observed synergistic effect of the combination of SRT1720 and Oroxylin-A.
Review
Endocrinology & Metabolism
Manasi Das, Consuelo Sauceda, Nicholas J. G. Webster
Summary: Mounting evidence suggests that mitochondrial dysfunction may play a crucial role in the pathogenesis of various diseases such as type 2 diabetes, aging, and ovarian failure. Understanding the molecular mechanisms behind mitochondrial dysregulation and its implications in metabolic alterations and reproductive abnormalities is essential for disease research. Studies in different human populations and genetically manipulated rodents provide evidence for the impact of mitochondrial dysfunction in disease development.
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Cristina Gatto, Angela Di Porzio, Raffaella Crescenzo, Valentina Barrella, Susanna Iossa, Arianna Mazzoli
Summary: The short-term consumption of a high-fructose diet has a significant impact on skeletal muscle metabolism, with more pronounced effects in young individuals than in adults. The study found that young rats showed marked mitochondrial dysfunction and increased oxidative damage, leading to a decrease in insulin sensitivity. These findings highlight the importance of reducing fructose intake, especially in young people, to maintain metabolic health.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Ali H. Eid, Ludmila V. Nedosugova, Antonina V. Starodubova, Tatyana V. Popkova, Evgeny E. Bezsonov, Alexander N. Orekhov
Summary: PCOS is the most common endocrine-metabolic disorder worldwide, associated with anovulation, mitochondrial dysfunctions, and hormonal disbalance; patients with PCOS have elevated levels of inflammatory markers, highlighting the need for further research to understand the pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal Sekhar
Summary: This study conducted a 36-week clinical trial in older adults, showing that GlyNAC supplementation for 24 weeks improved red-blood cell GSH deficiency, oxidative stress, and mitochondrial dysfunction in older adults. It also improved inflammation, endothelial dysfunction, insulin resistance, genomic damage, cognition, strength, gait-speed, exercise capacity, and lowered body fat and waist circumference. However, the benefits declined after stopping GlyNAC supplementation for 12 weeks.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Owen Davis Sanders, Lekshmy Rajagopal, Chandler Chase Barton, Jayalekshmi Archa Rajagopal, Olga Lopez, Kalei Lopez, Fayeza Malik
Summary: The low cerebral metabolic rate of oxygen in Alzheimer's disease patients' medial temporal lobes suggests mitochondrial dysfunction caused by oxidative stress and DNA damage, which may contribute to tissue hypoxia. This finding helps us to better understand the pathogenesis of Alzheimer's disease.
Article
Biology
Jivanka Mohan, Terisha Ghazi, Thabani Sibiya, Anil A. A. Chuturgoon
Summary: The use of antiretrovirals is associated with mitochondrial dysfunction and metabolic syndrome. A study found that the usage of Tenofovir disoproxil fumarate, Lamivudine, and Dolutegravir induced mitochondrial stress and dysfunction in liver cells, which could contribute to the progression of insulin resistance. These findings can help in developing therapies with reduced side effects related to metabolic syndrome.
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Biochemistry & Molecular Biology
Giada De Benedittis, Andrea Latini, Serena Colafrancesco, Roberta Priori, Carlo Perricone, Lucia Novelli, Paola Borgiani, Cinzia Ciccacci
Summary: This study found a significant decrease in mtDNA copies in the peripheral blood of Sjogren's syndrome (SS) patients, as well as expression variations in genes related to mitochondrial dynamics. These results provide further insight into the potential involvement of mitochondrial dysfunctions in SS disease.
Article
Biochemistry & Molecular Biology
Qiuyan Li, Xuye Jiang, Yujia Zhou, Yingying Gu, Yijie Ding, Jing Luo, Nengzhi Pang, Yan Sun, Lei Pei, Jie Pan, Mengqi Gao, Sixi Ma, Ying Xiao, De Hu, Feilong Wu, Lili Yang
Summary: A high-fat diet can lead to insulin resistance in skeletal muscle, accompanied by mitochondrial dysfunction and oxidative stress. Nicotinamide riboside (NR) can improve mitochondrial function and reduce oxidative stress by increasing nicotinamide adenine dinucleotide (NAD). However, whether NR can ameliorate insulin resistance in skeletal muscle is still uncertain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Juergen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Loss of hepatic mitochondrial adaptation characterizes NASH and type 2 diabetes or hepatic fibrosis and may thereby favor accelerated disease progression.
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Jurgen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Individuals with type 2 diabetes have a higher risk of progressing from nonalcoholic fatty liver to steatohepatitis, fibrosis, and cirrhosis. The hepatic mitochondrial function in NASH patients with and without type 2 diabetes differs, impacting disease progression.
Article
Biochemistry & Molecular Biology
Rory S. Carroll, Juan Du, Brianne R. O'Leary, Garett Steers, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Summary: Pharmacological ascorbate (high dose given intravenously) selectively kills cancer cells compared to normal cells by generating hydrogen peroxide (H2O2). H2O2 activates the RAS-RAF-ERK1/2 signaling pathway, which leads to mitochondrial fission through phosphorylation of dynamin-related protein (Drp1). However, sustained increases in H2O2 also activate the ERK-Drp1 pathway, resulting in an adaptive response. Inhibition of this pathway enhances the toxicity of pharmacological ascorbate to cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Amina G. Ramadan, Wafaa M. Abdel-Rehim, Rasha A. El-Tahan, Samar S. Elblehi, Maher A. Kamel, Sara A. Shaker
Summary: This study aimed to investigate the effects of maternal and/or paternal obesity on the ovarian tissues of the first-generation female offspring in rats. The results showed that maternal and paternal obesity had differential impacts on the ovarian health of the female offspring, leading to metabolic abnormalities and ovarian lesions.
SCIENTIFIC REPORTS
(2023)
Review
Health Care Sciences & Services
Ya-Ling Yang, Yen-Hsiang Chang, Chia-Jung Li, Ying-Hsien Huang, Ming-Chao Tsai, Pei-Yi Chu, Hung-Yu Lin
Summary: Hepatocellular carcinoma (HCC) remains one of the most lethal cancers globally, with no established curative plan for advanced cases and a poor prognosis. Studies show that miR-29a plays an important role in regulating tumorigenesis and tumor microenvironment development, with potential therapeutic implications in hepatoprotection and HCC progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Cheng-Fen Tsao, Yen-Hsiang Chang, Feng-Chih Shen, Yu-Jih Su, Hung-Yu Lin, Chia-Shiang Chang, Ching-Yi Lin, Wei-Shiung Lian, Jiin-Haur Chuang, Tsu-Kung Lin, Chia-Wei Liou, Pei-Wen Wang, Shao-Wen Weng
Summary: This study demonstrated that NAC can improve cellular senescence in a diet-induced obesity mouse model, with a legacy effect observed through early intervention. The main mechanisms behind this improvement include increased motor activity and anti-oxidative stress effects.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ya-Ling Yang, Ming-Chao Tsai, Yen-Hsiang Chang, Chen-Chen Wang, Pei-Yi Chu, Hung-Yu Lin, Ying-Hsien Huang
Summary: This study demonstrates the inhibitory effect of MIR29A on LOX, LOXL2, and VEGFA by targeting their 3' UTRs, leading to promotion of apoptosis and reduction in cell viability and wound healing. The results confirm that MIR29A-3p mimic can directly bind to the 3' UTRs of LOX and VEGFA to downregulate their gene and protein expression levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Hung-Yu Lin, Hui-Wen Ho, Yen-Hsiang Chang, Chun-Jui Wei, Pei-Yi Chu
Summary: Despite the challenges in clinical treatment of breast cancer due to high recurrence rates, ferroptosis has emerged as a promising avenue for targeting drug-resistant cancer cells. Advances in the development of clinical drugs targeting ferroptosis offer hope for improved breast cancer treatment outcomes in the future. Additionally, research into biomarkers for tracing ferroptosis and novel therapies based on this cell death process will be crucial in the coming years.
Review
Oncology
Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
Summary: Breast cancer emergencies have rapidly evolved in medicine over the past decade, with targeted therapy emerging as a new important treatment modality that offers advantages over traditional surgery, radiotherapy, and chemotherapy.
Article
Biochemistry & Molecular Biology
Kai-Tun Chang, Hsing-Ju Wu, Chien-Wei Liu, Chia-Ying Li, Hung-Yu Lin
Summary: This study revealed the significance of KCNQ1 in diagnosis, prognosis, and precision medicine approach of lung adenocarcinoma (LUAD) through multi-omics analysis. High KCNQ1 levels were associated with favorable prognosis, and negatively correlated with tumor proliferation and migration ability. KCNQ1 was also involved in immune modulation and cell cycle inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ying-Hsien Huang, Wei-Shiung Lian, Feng-Sheng Wang, Pei-Wen Wang, Hung-Yu Lin, Ming-Chao Tsai, Ya-Ling Yang
Summary: A high-fat diet leads to hepatic fat accumulation and increases the risk of chronic liver damage and hepatocellular carcinoma (HCC). The study shows that miR-29a regulates the HIF-1α and ANGPT2 signaling pathways in HCC formation, providing insights into a novel molecular pathway for preventing HCC development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ying-Hsien Huang, Feng-Sheng Wang, Pei-Wen Wang, Hung-Yu Lin, Sheng-Dean Luo, Ya-Ling Yang
Summary: Heat shock protein 60 (HSP60) can provide hepatoprotection in the context of non-alcoholic fatty liver disease (NAFLD) by inhibiting dsRNA release and the TLR3/MDA5/pIRF3 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Chun-Chi Chen, Pei-Yi Chu, Hung-Yu Lin
Summary: Using multi-omics analysis, this study reveals the clinical value and possible mechanisms of ATAD1 in prostate adenocarcinoma (PRAD). The downregulation of ATAD1 serves as a clinical biomarker for pathologic diagnosis and prognosis in PRAD patients. It is involved in enhanced activity of mitochondria and cell cycle as well as shaping an immunosuppressive tumor microenvironment.
Review
Cell Biology
Kai-Jung Lin, Shang-Der Chen, Kai-Lieh Lin, Chia-Wei Liou, Min-Yu Lan, Yao-Chung Chuang, Pei-Wen Wang, Jong-Jer Lee, Feng-Sheng Wang, Hung-Yu Lin, Tsu-Kung Lin
Summary: Parkinson's disease is the second most common neurodegenerative disease and is associated with iron accumulation and iron-dependent phospholipid peroxidation, which leads to a novel cell death pathway called ferroptosis. Recent research has focused on targeting ferroptosis as a potential intervention for PD.
Article
Biochemistry & Molecular Biology
Chun-Chi Chen, Pei-Yi Chu, Hung-Yu Lin
Summary: This study investigated the clinical significance of Inner membrane mitochondrial protein (IMMT) in Kidney renal clear cell carcinoma (KIRC) using supervised learning and multi-omics integration. The results showed that low expressions of IMMT in tumors were associated with poor prognosis, tumor progression, mitochondrial inhibition, angiogenetic activation, reduced immunogenicity, and an immunosuppressive tumor immune microenvironment (TIME). Inter-database verification further confirmed these findings. Pharmacogenetic prediction identified potential drug efficacy in the context of low IMMT expressions. IMMT has the potential to be a novel biomarker, prognostic predictor, and pharmacogenetic predictor for personalized cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hung-Yu Lin, Hsing-Ju Wu, Pei-Yi Chu
Summary: This study utilized multi-omics analysis and experimental verification to demonstrate the clinical significance of IMMT in breast cancer (BC), showing its association with poor prognosis, impact on the immune microenvironment, cell cycle, and mitochondrial function, and identifying a potential drug candidate.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Medicine, General & Internal
Shang-Ting Tsai, Hung-Yu Lin, Chia-Ying Li, Chih-Chien Lin
Summary: This study evaluates the effectiveness of a dedicated APS Rib Fixation System in the treatment of flail chest. The pre-contoured design of the APS plate demonstrates fewer cases of plate fractures and screw dislocations compared to the traditional Mini bone plate.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Ya-Lei Niu, Nicola Patrick Mayr, Yin-Hwa Chen, Hsiao-Hwang Chang, Shi-Pu Wang, Hung-Yu Lin, Ching-Chou Pai
Summary: Transcatheter aortic valve implantation (TAVI) is the preferred treatment for severe aortic stenosis in high-risk patients. Extracorporeal membranous oxygenation (ECMO) can be used to treat cardiogenic shock during the procedure. This case report describes the successful use of ECMO in an 88-year-old female patient undergoing TAVI.
MEDICINA-LITHUANIA
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)