Article
Medicine, Research & Experimental
Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Gabriela Alexandra Mihali, Beatrice Arosio, Mario Clerici
Summary: The concentration of miR-451a in serum was significantly increased in frail patients, while the concentrations of miR-93-5p and miR-495-3p were reduced, and miR-155-5p was increased. The multicomponent exercise program was able to improve physical performance and muscle strength in frail patients and modulate the expression of miRNAs in serum.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Francesca La Rosa, Simone Agostini, Marina Saresella, Andrea Saul Costa, Federica Piancone, Rossella Miglioli, Fabio Trecate, Mario Clerici
Summary: The study showed that rehabilitation in sarcopenic patients led to significant improvements in physical and cognitive conditions, as well as a reduction in inflammation. Additionally, the rehabilitation protocol increased the concentration of miRNAs known to regulate IL-37 production, suggesting IL-37 may be a potential therapeutic target for sarcopenic patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Johanna Nilsson, Nicholas J. Ashton, Andrea L. Benedet, Laia Montoliu-Gaya, Johan Gobom, Tharick A. Pascoal, Mira Chamoun, Erik Portelius, Andreas Jeromin, Muriel Mendes, Henrik Zetterberg, Pedro Rosa-Neto, Ann Brinkmalm, Kaj Blennow
Summary: This study compared the Simoa and IP-MS methods for quantifying the expression levels of the presynaptic protein SNAP-25. The results showed a strong correlation between the two methods and demonstrated their ability to effectively identify clinical manifestations of AD pathology. Additionally, the study found that CSF levels of SNAP-25 were associated with amyloid pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Endocrinology & Metabolism
Irina Churilov, Leonid Churilov, Kim Brock, David Murphy, Richard J. MacIsaac, Elif Ekinci
Summary: This study aimed to estimate the prevalence of sarcopenia and investigate its association with functional performance in patients with and without diabetes during inpatient rehabilitation. The results showed that sarcopenia was associated with reduced functional performance in patients with diabetes, but not in those without diabetes. Further research is needed to understand the progression of patients with dual diagnoses of diabetes and sarcopenia in inpatient rehabilitation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Health Care Sciences & Services
Luigia Brugliera, Alessandra Giordani, Giuseppe D'Angelo, Caterina Trimarchi, Giulia Villa, Tao-Yu Yen, Francesco Bosica, Lorenzo Malatino, David Zweiker, Alessandra Negro, Federica Alemanno, Sandro Iannaccone
Summary: The prevalence of sarcopenia and its related factors in patients aged ≥65 years admitted to the neurological rehabilitation departments in Milan were investigated in this study. Using the algorithm of EWGSOP2, 47.9% of the recruited patients were found to have definite sarcopenia. Sarcopenic patients had higher age, lower height, weight, and body mass index, and showed reduced life autonomy and increased mental impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Ayaka Matsumoto, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Eiji Kose, Fumihiko Nagano, Takahiro Bise, Yoshifumi Kido, Sayuri Shimazu, Ai Shiraishi
Summary: This study investigated the effect of deprescribing for polypharmacy on nutritional intake and sarcopenia improvement in older patients with sarcopenia. The results showed that deprescribing was associated with improved nutritional intake.
Article
Pharmacology & Pharmacy
Mengying Niu, Hong Li, Xu Li, Xiaoqian Yan, Aijun Ma, Xudong Pan, Xiaoyan Zhu
Summary: This study identified four promising exosomal miRNAs associated with large-artery atherosclerosis (LAA) stroke, the most common subtype of ischemic stroke, through high-throughput sequencing and qRT-PCR analysis. These miRNAs can serve as diagnostic biomarkers for LAA stroke, showing superior diagnostic efficiency compared to their plasma counterparts.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Shinta Nishioka, Tatsuya Matsushita, Anna Yamanouchi, Yuka Okazaki, Kana Oishi, Emi Nishioka, Natsumi Mori, Yoshiharu Tokunaga, Shinya Onizuka
Summary: Malnutrition and sarcopenia often coexist in rehabilitation patients, with a prevalence rate of 23.5%. Age, onset-admission interval, hospital-associated deconditioning, and swallowing ability were identified as independent explanatory factors for Co-MS.
Article
Clinical Neurology
Pia Kivisakk, Becky C. Carlyle, Thadryan Sweeney, James P. Quinn, Christopher E. Ramirez, Bianca A. Trombetta, Muriel Mendes, Mary Brock, Carrie Rubel, Julie Czerkowicz, Danielle Graham, Steven E. Arnold
Summary: This study measured the levels of synaptic proteins in cerebrospinal fluid (CSF) and found that these proteins could potentially serve as biomarkers for cognitive decline in Alzheimer's disease (AD). The levels of the synaptic proteins were higher in AD patients compared to those with other neurodegenerative diseases and healthy controls, but were not specific to AD and could also be present in cases with inflammatory or vascular disorders.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Nutrition & Dietetics
Ayano Nagano, Akio Shimizu, Keisuke Maeda, Junko Ueshima, Tatsuro Inoue, Kenta Murotani, Yuria Ishida, Naoharu Mori
Summary: This study aimed to identify the cutoff values of temporal muscle thickness (TMT) measured using computed tomography to identify sarcopenia in stroke patients. The study found a valid cutoff value for identifying sarcopenia after acute stroke, which may be useful for early detection of muscle wasting.
Review
Biochemistry & Molecular Biology
Maria Alexandra Angelescu, Octavian Andronic, Simona Olimpia Dima, Irinel Popescu, Irit Meivar-Levy, Sarah Ferber, Daniela Lixandru
Summary: Diabetes mellitus is a complex disease that requires early diagnosis and treatment to prevent complications. MiRNAs have shown promise as biomarkers for early detection and monitoring of the disease. Further research is needed to validate their effectiveness in diagnosing and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Megan Hetherington-Rauth, Eileen Johnson, Eugenia Migliavacca, Neeta Parimi, Lisa Langsetmo, Russell T. Hepple, Yohan Grzywinski, John Corthesy, Terence E. Ryan, Luigi Ferrucci, Jerome N. Feige, Eric S. Orwoll, Peggy M. Cawthon
Summary: This study investigates the associations between amino acids, B vitamins, and their metabolites with D3Cr muscle mass in older men. The results suggest that tryptophan and alpha-hydroxy-5-methyl-tetrahydrofolate (hm-THF) have significant correlations with D3Cr muscle mass, walking speed, and grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Environmental Sciences
Li Shi, Lingfang Feng, Yan Tong, Junlin Jia, Tao Li, Jing Wang, Zhaoqiang Jiang, Min Yu, Hailing Xia, Qi Jin, Xiyi Jiang, Yongran Cheng, Li Ju, Jiaqi Liu, Quan Zhang, Jianlin Lou
Summary: The study identified differentially expressed miRNAs in the DNA damage response induced by Cr (VI) exposure, indicating potential roles of several miRNAs in cell apoptosis and DDR.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Diana Karen Mendiola-Soto, Diego Alberto Barcenas-Lopez, Carlos Jhovani Perez-Amado, Gabriela Marisol Cruz-Miranda, Juan Manuel Mejia-Arangure, Julian Ramirez-Bello, Alfredo Hidalgo-Miranda, Silvia Jimenez-Morales
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and although cure rates have increased, a significant number of patients still relapse. The role of microRNAs (miRNAs) as non-coding RNA genes in ALL has gained interest in terms of understanding the disease's molecular mechanisms and identifying clinical biomarkers. Consistent findings suggest that miRNAs can be useful in distinguishing between different types of leukemia and predicting chemotherapy response. However, there is limited research on the molecular interplay between miRNAs and their targeted genes. This review aims to discuss the various ways miRNAs could be involved in ALL and their clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
R. Gamberale, C. D'Orlando, S. Brunelli, R. Meneveri, P. Mazzola, G. Foti, G. Bellani, G. Zatti, D. Munegato, S. Volpato, A. Zurlo, G. Caruso, A. Andreano, M. G. Valsecchi, G. Bellelli
Summary: This pilot study aims to evaluate the feasibility of a larger study exploring the pathophysiological mechanisms correlating postoperative delirium (POD) with sarcopenia, by analyzing biomarkers in blood, cerebrospinal fluid (CSF), and muscles of older patients with hip fracture. Two centers will recruit ten patients each for baseline assessments and biomarker analyses, aiming to improve understanding of the relationship between POD and sarcopenia.
Article
Biochemistry & Molecular Biology
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Silvia Picciolini, Domenico Caputo, Marco Rovaris, Maria Barbara Pasanisi, Mario Clerici
Summary: Approximately 15% of MS patients develop primary progressive form of disease, which is difficult to diagnose and treat. Brain-derived EVs and their protein cargoes could potentially serve as biomarkers for MS. The study found that MBP concentration in ODEVs was significantly increased in MS patients and correlated with disease severity. A minimally invasive blood test measuring MBP concentration in ODEVs could be a promising tool for MS diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Gabriela Alexandra Mihali, Beatrice Arosio, Mario Clerici
Summary: The concentration of miR-451a in serum was significantly increased in frail patients, while the concentrations of miR-93-5p and miR-495-3p were reduced, and miR-155-5p was increased. The multicomponent exercise program was able to improve physical performance and muscle strength in frail patients and modulate the expression of miRNAs in serum.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Simone Agostini, Elisabetta Bolognesi, Roberta Mancuso, Ivana Marventano, Lorenzo Agostino Citterio, Franca Rosa Guerini, Mario Clerici
Summary: The concentration of specific miRNAs (miR-27b-3p, miR-181a-5p, and miR-23a-3p) was found to be associated with a SNAP-25 polymorphism. In vitro experiments confirmed that miR-181a-5p and miR-23a-3p regulate SNAP-25 gene and protein expression, while miR-27b-3p does not. These findings suggest the potential use of miR-181a-5p and miR-23a-3p as biomarkers or therapeutic targets for diseases involving altered SNAP-25 expression.
Article
Biochemistry & Molecular Biology
Anna Maria Auxilia, Massimiliano Buoli, Alice Caldiroli, Greta Silvia Carnevali, Agnese Tringali, Roberto Nava, Massimo Clerici, Enrico Capuzzi
Summary: Treatment discontinuation is a challenge in clinical settings. Long acting injectable (LAI) antipsychotics are underutilized despite their potential benefits. This study aimed to identify the factors associated with LAI discontinuation in a real-world setting.
Article
Psychiatry
Cecilia Maria Esposito, Anna Maria Auxilia, Alessandro Ceresa, Francesco Giuseppe Zanvit, Francesco Zanelli Quarantini, Enrico Capuzzi, Alice Caldiroli, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to examine the factors associated with duration of untreated illness (DUI) in borderline personality disorder (BPD). A chart review of 152 patients followed up by community psychiatry services in Milan and Monza, Italy was conducted. Pearson correlation and analyses of variances were used to analyze the association between DUI and socioeconomic and clinical variables. The results showed that a longer DUI was associated with several variables, but these associations were not maintained in the regression analyses. Therefore, DUI does not appear to be significantly associated with specific clinical aspects of BPD or the course and outcome of the disorder. Larger studies are needed to confirm these findings.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Letter
Medicine, General & Internal
Enrico Capuzzi, Alice Caldiroli, Francesca Cella, Marco Turco, Massimiliano Buoli, Massimo Clerici
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Vanetti, Vito Lampasona, Marta Stracuzzi, Claudio Fenizia, Mara Biasin, Irma Saulle, Fiona Limanaqi, Ahmed Abdelsalam, Cristian Loretelli, Laura Paradiso, Emma Longoni, Lucia Barcellini, Lorenzo Piemonti, Ilaria Marzinotto, Stefania Dispinseri, Antonella Amendola, Clara Fappani, Elisabetta Tanzi, Mario Salvatore Clerici, Gabriella Scarlatti, Gian Vincenzo Zuccotti, Vania Giacomet, Daria Trabattoni
Summary: This study analyzed the immune profiles of 18 hospitalized children with SARS-CoV-2 infection and found that different severity levels of children cases showed different immune characteristics. Infants with severe symptoms exhibited high inflammatory response and extreme antibody response, while mild cases had lower levels of inflammation and antibodies. Overall, the immune response in children is directly correlated with the clinical severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Clerici
Summary: Alzheimer's Disease (AD) is the most common form of dementia, characterized by the deposition of neurotoxic plaques composed of amyloid-beta (Ab). Peripheral inflammation has been identified as an early event in AD pathogenesis. This study focuses on TREM2, a receptor that plays a role in immune cell function and may serve as a potential peripheral biomarker for AD diagnosis and prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychiatry
Ester di Giacomo, Elena Andreini, Ottavia Lorusso, Massimo Clerici
Summary: Narcissistic personality disorder is characterized by self-absorption, grandiosity, exploitation of others, and lack of empathy. People with this disorder may switch between overt and covert presentations, with the latter exhibiting fears, hypersensitivity, and dependence on others. Empathy is a key factor in detecting narcissistic personality disorder, as it plays a fundamental role in their exploitation and manipulation. This review found that individuals with narcissistic personality disorder show greater impairment in affective aspects of empathy, while their cognitive empathy remains intact.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Mario Meloni, Cristina Agliardi, Franca Rosa Guerini, Francesca Lea Saibene, Anna Vera Milner, Milena Zanzottera, Elisabetta Bolognesi, Monica Puligheddu, Michela Figorilli, Jorge Navarro, Mario Clerici
Summary: REM sleep behavior disorder (RBD) is more closely related to synucleinopathies in Parkinson's Disease (PD) compared to other neurodegenerative disorders. This study explores the potential biomarkers for RBD using neural-derived extracellular vesicles (NDEVs) in serum. The findings suggest that serum concentrations of NDEVs' oligomeric a-Syn and SNARE complex components could serve as reliable biomarkers for the RBD-specific PD endophenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Irma Saulle, Micaela Garziano, Gioia Cappelletti, Fiona Limanaqi, Sergio Strizzi, Claudia Vanetti, Sergio Lo Caputo, Mariacristina Poliseno, Teresa Antonia Santantonio, Mario Clerici, Mara Biasin
Summary: This study found that the changes in miRNAs, cytokines, and neutralizing activity in the saliva and plasma of COVID-19 patients are associated with disease severity. Compared to mild patients, severe patients showed significant differences in the expression of 8 miRNAs in their saliva and plasma, with increased expression of immune regulatory miRNAs and decreased expression of others.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fabiola Giovanna Mestanza Mattos, Francesco Luciano, Tiziana Lencioni, Elisa Gervasoni, Johanna Jonsdottir, Denise Anastasi, Gaspare Pavei, Mario Clerici, Davide Cattaneo
Summary: Gait alterations in people with multiple sclerosis (PwMS) were analyzed using the Gait Profile Score (GPS) and Statistical Parametric Mapping (SPM). The GPS of PwMS was higher than that of healthy controls (HC), indicating greater gait abnormalities. SPM analysis revealed significant joint angle deviations, particularly at the ankle and knee, during different phases of the gait cycle. Additionally, GPS correlated with clinical outcome measures.
SCIENTIFIC REPORTS
(2023)
Review
Biology
Cristina Agliardi, Franca Rosa Guerini, Elisabetta Bolognesi, Milena Zanzottera, Mario Clerici
Summary: The pathogenesis of autoimmune diseases is still unclear and may involve genetic variants and environmental triggers. Vitamin D and its receptor (VDR) have been associated with autoimmune diseases. This review summarizes the involvement of four well-studied VDR gene polymorphisms in autoimmune conditions and highlights the need for further investigation.
Article
Chemistry, Medicinal
Roberta Mancuso, Lorenzo Agostino Citterio, Simone Agostini, Ivana Marventano, Francesca La Rosa, Francesca Re, Pierfausto Seneci, Marina Saresella, Mario Clerici, Leonidas A. Phylactou
Summary: The anti-hyperglycemic drug glibenclamide and bi-functionalized liposomes are capable of inhibiting NLRP3 inflammasome activation and reducing the release of inflammatory cytokines. They also have the ability to modulate the expression of certain miRNAs. These findings suggest a potential new strategy for treating neurodegenerative diseases using glibenclamide and liposomes.