Review
Cell Biology
Diana Pereira, Ines Sequeira
Summary: Epithelial tissues have a natural ability for renewal and regeneration, crucial for providing the ultimate barrier against the external environment. The oral mucosa is known for its outstanding healing potential with minimal scarring, contributing to reducing fibrotic tissue formation. The combination of cell therapy and bioengineering to leverage the scarless properties of the oral mucosa for skin and esophageal wound healing is a promising avenue for achieving scarless wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Emergency Medicine
Tingting Weng, Jialiang Wang, Min Yang, Wei Zhang, Pan Wu, Chuangang You, Chunmao Han, Xingang Wang
Summary: Dermal substitutes provide an ideal clinical treatment for deep skin defects, but rapid vascularization remains a challenge. Understanding the mechanism of delivering bioactive factors is crucial for promoting angiogenesis. Nanomaterials show potential in effectively delivering bioactive factors, thus enhancing angiogenesis in dermal substitutes.
Article
Chemistry, Multidisciplinary
Peikun Xin, Shuyan Han, Jun Huang, Conglai Zhou, Jiayuan Zhang, Xinru You, Jun Wu
Summary: Chronic diabetic wounds, characterized by long-term high levels of oxidative stress and blood sugar, present the biggest challenge in wound healing research. Edible natural biomaterials rich in terpenes, phenols, and flavonoids have shown potential as efficient antioxidants. Okra extract, selected as the main component of a wound dressing, displayed robust antioxidant properties, reducing reactive oxygen species and promoting wound healing in diabetic rats.
CHINESE CHEMICAL LETTERS
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Ponrasu Thangavel, Hemalatha Kanniyappan, Sudip Chakraborty, Shipra Chaudhary, Aadinath Wallepure, Vignesh Muthuvijayan
Summary: Biomimetic scaffolds were prepared using konjac glucomannan (KGM) and silk fibroin (SF), which were cross-linked with citric acid and lyophilized to obtain fibrous structures. The KGM/SF scaffolds exhibited improved thermal stability, porous morphology, and biodegradable nature. They also showed enhanced compression strength and demonstrated biocompatibility, cell viability, and vascularization efficacy in tissue engineering and biomedical applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Emergency Medicine
Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin
Summary: This article summarizes the potential of cell electrospinning (C-ES) technology, based on the technique of electrospinning (ES), in promoting wound healing. It discusses the advantages of C-ES, the differences between C-ES and traditional ES, suitable parameters for maintaining cytoactivity, material selection and design, and the application of C-ES in biomaterials and cells. It also explores the limitations and improved methods of C-ES.
Article
Biochemistry & Molecular Biology
Leifeng Lyu, Yuanqing Cai, Guangyang Zhang, Zhaopu Jing, Jialin Liang, Rupeng Zhang, Xiaoqian Dang, Chen Zhang
Summary: In this study, exosomes derived from M2 macrophages were found to promote angiogenesis by inhibiting PTEN expression and activating the AKT/mTOR pathway in HUVECs. Furthermore, in a mouse model, M2-EXO was shown to promote angiogenesis and regeneration. These findings suggest that M2-EXO may serve as a promising nanomedicine strategy for skin healing.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Jonathan Klavert, Bram C. J. van der Eerden
Summary: Fibronectin (FN) plays a crucial role in bone fracture repair by guiding the assembly of additional ECM components and regulating cellular behavior. Strategies based on FN show great potential in tissue engineering and regenerative medicine applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Murugan Prasathkumar, Subramaniam Sadhasivam
Summary: Biomaterials play a crucial role in regenerative medicine, enhancing tissue development, repair, angiogenesis, and wound healing. These bioactive compounds derived from natural resources like chitosan, hyaluronic acid, alginate, etc., exhibit significant effects in wound healing and antimicrobial activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Engineering, Biomedical
Shirin Nour, Rana Imani, G. Rasul Chaudhry, Ali Mohammad Sharifi
Summary: This article provides a comprehensive overview of current and emerging angiogenesis induction methods for skin regeneration, aiming to accelerate wound healing. These methods are classified into cell-based, growth factor-based, scaffold-based, and biological/chemical compound-based strategies. The advantages and disadvantages of these angiogenic strategies are discussed along with relevant research examples to demonstrate their potential in wound treatment.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Cell Biology
Ming-Li Zou, Si-Yu Liu, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Ying-Ying Teng, Yi Feng, Feng-Lai Yuan
Summary: The incidence of acute and chronic wound diseases is increasing, causing a significant burden on patients, their families, and society due to their complex pathogenesis, long course, and difficult treatment. Research is focusing on identifying new ideas and methods for treatment, with adipose stem cells potentially playing a key role in wound healing.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Selma Benito-Martinez, Barbara Perez-Kohler, Marta Rodriguez, Jesus Maria Izco, Jose Ignacio Recalde, Gemma Pascual
Summary: This preclinical study compared the effects of a new collagen-based hydrolysate powder to a commercial non-hydrolysate product on wound repair in a murine model. The findings indicate that the new collagen treatment can significantly accelerate wound closure and promote the reparative process.
Review
Physiology
Monica Behara, Steven Goudy
Summary: In 2010, the FDA approved FTY720 as a therapy for relapsing forms of multiple sclerosis because it can sequester pro-inflammatory lymphocytes to prevent central nervous system damage. Current studies are exploring the regenerative impact of FTY720 in wound healing of muscle, bone, and mucosal injuries by harnessing its anti-inflammatory properties. In animal models, local delivery of FTY720 increased immune cell phenotypes, vascularization, cell proliferation, and collagen deposition, leading to enhanced regeneration in bone, muscle, and mucosal tissues.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ahmad Miri Jahromi, Aida Solhjoo, Mehdi Ghasemi, Mohammad Khedri, Reza Maleki, Lobat Tayebi
Summary: The study investigated the impact of COFs on the deformation of coronavirus spike protein structure through molecular dynamics simulation. It was found that COF-78 showed the best performance in preventing spike protein-ACE2 interactions by reducing protein compactness and exhibiting high contact area with aqueous media, which could be utilized for face masks and surface disinfection.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Chemical
Leila Mohammadi Amirabad, Mohammadreza Tahriri, Payam Zarrintaj, Reza Ghaffari, Lobat Tayebi
Summary: This study investigated the effects of a new coating process on the surface characteristics and properties of polymethyl methacrylate (PMMA). The results showed that the coating of titanium dioxide (TiO2) on PMMA improved its surface hydrophilicity without loss of TiO2. Cell attachment, viability, and fungal biofilm attachment were all found to be reduced on TiO2-coated PMMA. Overall, this research suggests a new way to enhance the surface energy of PMMAs for biomedical applications.
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Mohsen Akbarian, Marzieh Bahmani, Shu-Hui Chen, Reza Yousefi, Soliman Mohammadi-Samani, Lobat Tayebi, Farhad Panahi, Fatemeh Farjadian
Summary: In this study, the mechanism of insulin fibrillation and the cytotoxicity of insulin fibrils were investigated using plant derivatives. It was found that analogs with higher hydrophobicity could reduce fibrillation rate and cross-linking degree, and exhibited low toxicity to neural cells. Negatively charged analogs were able to reduce fibrillation in acidic environment but had the opposite effect in neutral environment. Moreover, different compounds could have different effects on surface ligands of neural cells.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Mohsen Akbarian, Luiz E. Bertassoni, Lobat Tayebi
Summary: This article introduces the importance of angiogenesis and factors involved in its control. In tissue engineering and regenerative medicine, angiogenesis is a crucial process for tissue repair.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Biomedical
Daniela S. Masson-Meyers, Fahimeh Tabatabaei, Lane Steinhaus, Jeffrey M. Toth, Lobat Tayebi
Summary: The development of vascularized scaffolds is a major challenge in tissue engineering, and co-culturing with endothelial cells is a possible approach. In this study, human umbilical vein endothelial cells (HUVECs) and fibroblasts were cultured on collagen scaffolds using different culture conditions. The results showed that collagen gel scaffolds supported cell proliferation and viability, while collagen sponge scaffolds were fragile and lacked signs of vascularization. However, under the experimental conditions, the HUVEC/fibroblast-seeded scaffolds were not suitable for generating in vitro prevascularized equivalents.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Chemistry, Physical
Farshid Vahdatinia, Amirarsalan Hooshyarfard, Shokoofeh Jamshidi, Setareh Shojaei, Kishan Patel, Erfan Moeinifard, Rasool Haddadi, Maryam Farhadian, Leila Gholami, Lobat Tayebi
Summary: This study examined the efficacy of a 3D-printed gelatin/elastin/sodium hyaluronate membrane for guided tissue regeneration (GTR) in a critical-size periodontal canine model. The membrane showed the potential to replace collagen membranes for cost-effective GTR therapies.
Review
Chemistry, Multidisciplinary
Reza Abbasi, Ghazal Shineh, Mohammadmahdi Mobaraki, Sarah Doughty, Lobat Tayebi
Summary: The growing interest in using nanoparticles (NPs) for biomedical applications has raised concerns about their safety and toxicity. NPs, compared with bulk materials, are more chemically active and toxic due to their larger surface area and smaller size. Understanding the mechanism of NP toxicity and the factors affecting their behavior in biological environments can aid in the development of NPs with reduced side effects and improved performance. This review discusses the classification, properties, and biomedical applications of NPs, as well as their toxicity mechanisms and interactions with living components.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mahsa Janmohammadi, Mohammad Sadegh Nourbakhsh, Marjan Bahraminasab, Lobat Tayebi
Summary: Polycaprolactone scaffolds with different pore shapes and sizes were 3D-printed and modified with alkaline hydrolysis. The study focused on the effects of pore size, porosity, pore shapes, surface modification, biomineralization, mechanical properties, and biological characteristics on bone ingrowth. Results showed that treated scaffolds had increased surface roughness but decreased structural integrity, especially in scaffolds with small pores and a triangle shape. Scaffolds with triangle shape and smaller pore size exhibited superior mechanical strength similar to cancellous bone. In vitro studies showed increased cell viability in scaffolds with cubic pore shapes and small pore sizes, while mineralization was enhanced in designs with larger pore sizes. This study demonstrated that modified polycaprolactone scaffolds have favorable mechanical and biological properties for bone tissue engineering.
Review
Materials Science, Composites
Fereshte Rezaie, Masoud Farshbaf, Mohammad Dahri, Moein Masjedi, Reza Maleki, Fatemeh Amini, Jonathan Wirth, Keyvan Moharamzadeh, Franz E. Weber, Lobat Tayebi
Summary: Revolutionary fabrication technologies like 3D printing are expected to replace traditional methods in dental structure development due to their ability to create constructs with required properties and detailed structures. This review article explores the recent applications of 3D printing techniques in dental prosthetics manufacturing, including various printing techniques, materials used, and limitations/challenges faced. The article also utilizes major scientific databases to find relevant literature on dental prostheses 3D printing.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Materials Science, Composites
Mahyar Naseri, Aysan Hedayatnazari, Lobat Tayebi
Summary: Infectious diabetic wounds can be severe and even fatal. Creating a biocompatible wound dressing with suitable hydrophilicity and biodegradation rate is challenging. In this study, we used the electrospinning method to create a wound dressing composed of PGS and Gel, and observed improved hydrophilicity and increased cell growth on the scaffolds. Our findings suggest that the PGS/Gel scaffold has potential for wound healing applications.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Review
Engineering, Biomedical
Ghazal Shineh, Kishan Patel, Mohammadmahdi Mobaraki, Lobat Tayebi
Summary: This review discusses the treatment methods for critical-sized bone defects (CSDs) and the importance of vascularization in this process.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Nima Farshidfar, Sahar Assar, Mohammad Amin Amiri, Sarina Sahmeddini, Shahram Hamedani, Moein Zarei, Lobat Tayebi
Summary: Three-dimensional cell culture models have improved the simulation of cell behavior in imitating the body's conditions. Microfluidic tissues/organs-on-chips (TOOCs) provide a method of culturing cells in conditions similar to the body's physiology. While these structures have been developed for various tissues and organs, their application in oral and dental tissues is not widespread. The application of TOOCs for oral tissues can study interactions with dental biomaterials and accurately study the cellular interactions and developmental stages.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Engineering, Biomedical
Mahsa Janmohammadi, Mohammad Sadegh Nourbakhsh, Marjan Bahraminasab, Lobat Tayebi
Summary: Tissue-engineered bone substitutes with favorable physicochemical, mechanical, and biological properties offer a promising alternative for bone defect repair. In this study, we successfully integrated a guest component into a host-guest scaffold model, resulting in enhanced bioactivity and increased strength. The designed scaffolds demonstrated ion release, surface apatite formation, and biodegradation, and exhibited improvements in cell viability, proliferation, and attachment. Furthermore, the multicompartment scaffolds showed remarkable osteogenic properties.
MATERIALS TODAY BIO
(2023)
Review
Materials Science, Biomaterials
Saeid Alipour, Shirin Nour, Seyyed Morteza Attari, Mohammad Mohajeri, Sogol Kianersi, Farzaneh Taromian, Mohammadparsa Khalkhali, George E. Aninwene, Lobat Tayebi
Summary: Bone replacement using personalized titanium alloy implants has great potential in mimicking the complex structure of natural tissue and reducing the risk of implant failure. This review focuses on the most promising methods of fabricating such patient-specific Ti-6Al-4V implants using additive manufacturing, and discusses the optimization of tissue-implant interactions.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)