期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 96, 期 -, 页码 181-189出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2016.04.023
关键词
Oxidative stress; Fibrinogen; Coagulopathy; Methionine sulfoxide; Hemorrhage; Trauma
资金
- NIH [GM008695-09]
- NHLBI [1F32HL120549-01A1]
- National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) [KL2 TR000421]
Victims of trauma often develop impaired blood clot formation (coagulopathy) that contributes to bleeding and mortality. Fibrin polymerization is one critical component of clot formation that can be impacted by post-translational oxidative modifications of fibrinogen after exposure to oxidants. In vitro evidence suggests that A alpha-C domain methionine sulfoxide formation, in particular, can induce conformational changes that prevent lateral aggregation of fibrin protofibrils during polymerization. We used mass spectrometry of plasma from trauma patients to find that fibrinogen A alpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据