Article
Cardiac & Cardiovascular Systems
Eng Leng Saw, Louis Dominic Werner, Payman Zamani, Julio A. Chirinos, Maria Valero-Munoz, Flora Sam
Summary: The study focused on skeletal muscle phenotypic switching in heart failure with preserved ejection fraction (HFpEF) using a pre-clinical model called SAUNA mice. The results showed that the oxidative-predominant soleus muscle in HFpEF mice displayed reductions in oxidative fibers, type-2A fiber atrophy, decreased capillary density, and increased fibrotic area, along with changes in mitochondrial oxidative phosphorylation genes, VEGF-alpha expression, and inflammatory response. These findings suggest that the HFpEF SAUNA model accurately reflects skeletal muscle phenotypic changes seen in HFpEF patients, making it a valuable tool for further research in this field.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew Anderson, Clifton Forrest Parrott, Mark J. Haykowsky, Peter H. Brubaker, Fan Ye, Bharathi Upadhya
Summary: Nearly half of heart failure disease burden is attributed to HF with preserved ejection fraction (HFpEF). Patients with HFpEF suffer from severe exercise intolerance, which is associated with skeletal muscle abnormalities such as reduced muscle mass, decreased oxidative muscle fibers, abnormal fat infiltration, and impaired nitric oxide bioavailability. Exercise training and caloric restriction have shown to improve outcomes in HFpEF patients, emphasizing the importance of targeting skeletal muscle to improve exercise intolerance.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
J. C. Weavil, T. S. Thurston, T. J. Hureau, J. R. Gifford, P. A. Kithas, R. M. Broxterman, A. D. Bledsoe, J. N. Nativi, R. S. Richardson, M. Amann
Summary: HFpEF patients show similar central and peripheral fatigue development as healthy controls during exercise not limited by cardiac output at the same relative intensity. However, HFpEF patients exhibit a greater susceptibility to neuromuscular fatigue during exercise at a given absolute intensity, which impairs functional capacity. The compromised leg blood flow response likely contributes to the attenuated fatigue resistance in HFpEF patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yogesh N. V. Reddy, Glenn M. Stewart, Masaru Obokata, Katlyn E. Koepp, Barry A. Borlaug
Summary: Nitrite treatment improves oxygen transport and utilization during exercise in HFpEF patients by enhancing skeletal muscle oxygen conductance and pulmonary oxygen diffusion.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Multidisciplinary Sciences
Yuki Saito, Masaru Obokata, Tomonari Harada, Kazuki Kagami, Makoto Murata, Hidemi Sorimachi, Toshimitsu Kato, Naoki Wada, Yasuo Okumura, Hideki Ishii
Summary: Cardiopulmonary exercise testing (CPET) has potential value in differentiating HFpEF from NCD, but limited diagnostic ability was found in this study. Lower oxygen consumption (VO2) was observed in HFpEF patients compared to controls and those with NCD, but there was an overlap between HFpEF and NCD. Expired gas analysis data had modest abilities in distinguishing HFpEF from controls, but none of the variables clearly differentiated between HFpEF and NCD (all areas under the curve < 0.61). Expired gas analysis provides objective assessments of exercise capacity, yet its diagnostic value in identifying HFpEF among patients with symptoms of exertional dyspnea was modest.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Payman Zamani, Elizabeth A. Proto, Neil Wilson, Hossein Fazelinia, Hua Ding, Lynn A. Spruce, Antonio Davila, Thomas C. Hanff, Jeremy A. Mazurek, Stuart B. Prenner, Benoit Desjardins, Kenneth B. Margulies, Daniel P. Kelly, Zoltan Arany, Paschalis-Thomas Doulias, John W. Elrod, Mitchell E. Allen, Shana E. McCormack, Gayatri Maria Schur, Kevin D'Aquilla, Dushyant Kumar, Deepa Thakuri, Karthik Prabhakaran, Michael C. Langham, David C. Poole, Steven H. Seeholzer, Ravinder Reddy, Harry Ischiropoulos, Julio A. Chirinos
Summary: Patients with heart failure with preserved ejection fraction demonstrate impaired skeletal muscle oxidative phosphorylation capacity, reductions in the proportions of Type I myofibres, proteins required for OxPhos, and altered phosphorylation signalling in skeletal muscle, which may contribute to exercise intolerance.
Article
Cardiac & Cardiovascular Systems
T. Jake Samuel, Dalane W. Kitzman, Mark J. Haykowsky, Bharathi Upadhya, Peter Brubaker, M. Benjamin Nelson, W. Gregory Hundley, Michael D. Nelson
Summary: The study revealed that LV circumferential early diastolic strain rate was impaired in older obese patients with HFpEF compared to controls, and there was only modest correlation between LV relaxation and reduced peak (V)over dotO(2). On the other hand, it showed a stronger relationship between elevated LV filling pressures and exercise intolerance in determining future therapeutic priorities.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Masaaki Konishi, Nobuyuki Kagiyama, Kentaro Kamiya, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Emi Maekawa, Toshihiro Misumi, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Akihiro Makino, Kazuhiro Oka, Shin-Ichi Momomura, Yuya Matsue
Summary: A multicentre prospective cohort study found that sarcopenia is an independent predictor of 1-year mortality in both HFpEF and HFrEF, with a similar impact on mortality in both patient groups.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Eng Leng Saw, Swetha Ramachandran, Maria Valero-Munoz, Flora Sam
Summary: Skeletal muscle dysfunction contributes to exercise intolerance in patients with HFpEF, with pathophysiological alterations in muscle structure and function identified through recent animal and human studies. Therapeutic interventions targeting skeletal muscle, such as exercise training and novel pharmacological therapies, are proposed for treating HFpEF. Evidence suggests that skeletal muscle dysfunction plays a significant pathophysiological role in HFpEF, but further research is needed for a better understanding of its contribution.
CURRENT OPINION IN CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Kazumasa Manabe, Andrew W. D'Souza, Takuro Washio, Ryosuke Takeda, Sarah L. Hissen, John D. Akins, Qi Fu
Summary: Excessive sympathetic activity during exercise causes reduced oxygen delivery to active muscles, resulting in exercise intolerance. The underlying pathophysiology of exercise intolerance may differ between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). HFpEF patients show predominantly peripheral limitations involving inadequate vasoconstriction, while HFrEF is characterized by cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew K. Burrage, Moritz Hundertmark, Ladislav Valkovic, William D. Watson, Jennifer Rayner, Nikant Sabharwal, Vanessa M. Ferreira, Stefan Neubauer, Jack J. Miller, Oliver J. Rider, Andrew J. M. Lewis
Summary: The study found that HFpEF patients have a myocardial energy deficit, leading to abnormal cardiac function and pulmonary congestion during exercise, supporting an energetic basis for transient pulmonary congestion.
Article
Cardiac & Cardiovascular Systems
Graham H. Bevan, Trevor Jenkins, Richard Josephson, Sanjay Rajagopalan, Sadeer G. Al-Kindi
Summary: Plasma ET-1 levels are significantly associated with lower exercise oxygen consumption both at baseline and longitudinally over 24 weeks in HFpEF patients. Higher ET1 levels are associated with lower pVO2, indicating a negative impact on exercise tolerance in HFpEF. Future studies should explore the potential of Endothelin-1 antagonism in improving exercise tolerance in HFpEF.
Review
Medicine, Research & Experimental
Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao, Leiming Luo
Summary: HFpEF is a leading cause of hospitalizations and mortality in individuals aged 65 and above, with complex pathophysiology and difficulties in diagnosis. While treatment for HF with reduced ejection fraction has progressed rapidly, HFpEF poses a significant challenge due to the failure of current HF drugs to improve outcomes, highlighting the need for further research on the relationships between HFpEF, aging, and comorbidities.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Aysha Amjad, Peter H. Brubaker, Bharathi Upadhya
Summary: HFpEF, the most rapidly increasing form of heart failure, primarily affects older women and is associated with high morbidity, mortality, and healthcare costs. It is now recognized as a systemic disorder influenced by aging processes.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Verwerft, Lucie Soens, Jokke Wynants, Marc Meysman, Siddharth Jogani, Danielle Plein, Sarah Stroobants, Lieven Herbots, Frederik H. Verbrugge
Summary: This study provides a detailed description of hemodynamic and metabolic alterations in heart failure patients with preserved ejection fraction (HFpEF) through systematic assessment using cardiopulmonary exercise testing combined with exercise echocardiography. The study reveals various cardiac alterations and recommends further diagnostic testing and potential treatment changes in the majority of cases.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amit Saha, Kershaw Patel, Colby Ayers, Christie M. Ballantyne, Adolfo Correa, Christopher Defilippi, Michael E. Hall, Robert J. Mentz, Stephen L. Seliger, Wondwosen Yimer, Javed Butler, Jarett D. Berry, James A. De Lemos, Ambarish Pandey
Summary: Among Black adults, persistent or worsening levels of cardiac troponin I (hs-cTnI) are associated with an increased risk of heart failure (HF). Participants with incident, stable or improved, or worsened hs-cTnI elevation had higher HF risk compared to those without elevated hs-cTnI.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Emer Joyce, Colleen K. Mcillvennan, Jill Howie Esquivel, Andrew J. Sauer, Ashish Correa, Vanessa Blumer, Quentin R. Youmans, Jesus Alvarez-Garcia, Helena Chang, Jessica Overbey, Elena Deych, Shashank S. Sinha, Alanna Morris, Ersilia M. Defilippis, Nosheen Reza, Jillianne Code, Alexander G. Hajduczok, Marat Fudim, Brett Rollins, Justin M. Vader, Ileana L. Pina, Jeffrey Teuteberg, Shelley Zieroth, Randall C. Starling, Martha Gulati, Robert J. Mentz, Anuradha Lala
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Anthony E. Peters, William E. Kraus, Robert J. Mentz
Article
Cardiac & Cardiovascular Systems
Stephen J. Greene, Eric J. Velazquez, Kevin M. Anstrom, Robert A. Clare, Tracy A. DeWald, Mitchell P. Psotka, Andrew R. Ambrosy, Gerin J. Stevens, John Rommel, Tamas Alexy, Fassil Ketema, Dong-Yun Kim, Patrice Desvigne-Nickens, Bertram L. Pitt, Eric J. Eisenstein, Robert Mentz, TRANSFORM-HF Investigators
Summary: The TRANSFORM-HF trial compared the effects of torsemide and furosemide on patient-reported outcomes among patients with heart failure. The study found that there was no significant difference in improving symptoms or quality of life between torsemide and furosemide over a period of 12 months.
Article
Cardiac & Cardiovascular Systems
Anthony E. Peters, Robert M. Clare, Karen Chiswell, G. Michael Felker, Anita Kelsey, Robert Mentz, Adam D. DeVore
Summary: Heart failure guidelines recommend assessment of left ventricular ejection fraction (LVEF) to classify patients. However, LVEF alone may be insufficient to characterize patients with mildly reduced or preserved LVEF. Recommendations on additional testing are lacking, and there are limited data on use of echocardiographic features beyond LVEF in these patients.
CIRCULATION-HEART FAILURE
(2023)
Article
Physiology
Kanokwan Bunsawat, Heather L. Clifton, Stephen M. Ratchford, Jennifer R. Vranish, Jeremy K. Alpenglow, Mark J. Haykowsky, Joel D. Trinity, John J. Ryan, Paul J. Fadel, D. Walter Wray
Summary: The study found that patients with HFpEF have a reduced pressor response to static muscle contractions compared to healthy controls, which may be partly due to a blunted muscle metaboreflex. These findings indicate a disease-related dysregulation in neural cardiovascular control during exercise in patients with HFpEF.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Craig J. Beavers, Andrew P. Ambrosy, Javed Butler, Beth T. Davidson, Stormi E. Gale, Ileana L. Pina, Ioannis Mastoris, Nosheen Reza, Robert J. Mentz, Gregory D. Lewis
Summary: Iron deficiency affects approximately 50% of symptomatic heart failure patients and is associated with worse functional capacity, lower quality of life, and increased mortality. This document aims to provide a summary of the definition, epidemiology, pathophysiology of iron deficiency in heart failure, as well as pharmacological considerations for iron repletion strategies. It also highlights the growing body of clinical trial evidence on when, how, and in whom to consider iron repletion.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ersilia M. Defilippis, Robert J. Mentz, Anuradha Lala
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert J. Mentz, Jonathan H. Ward, Adrian F. Hernandez, Serge Lepage, David A. Morrow, Samiha Sarwat, Kavita Sharma, Scott D. Solomon, Randall C. Starling, Eric J. Velazquez, Kristin Williamson, Shelley Zieroth, Eugene Braunwald
Summary: The PARAGON-HF trial evaluated the effects of Sac/Val compared to Val on clinical outcomes in patients with HFpEF or HFmrEF. The PARAGLIDE-HF trial further investigated the use of Sac/Val in patients with recent worsening HF events and in specific populations not well represented in the PARAGON-HF trial, including those with de novo HF, severe obesity, and Black patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Arsalan Hamid, Wondwosen K. Yimer, Adebamike A. Oshunbade, Daisuke Kamimura III, Donald Clark, Ervin R. Fox, Yuan- Min, Paul Muntner, Daichi Shimbo, Ambarish Pandey, Amil M. Shah, Robert J. Mentz, Daniel W. Jones, Alain G. Bertoni, John E. Hall, Adolfo Correa, Javed Butler, Michael E. Hall
Summary: This study aimed to assess the independent effects of diabetes and hypertension on left ventricular (LV) remodeling in Black adults. Through a cross-sectional analysis of Black adults, it was found that diabetes was only associated with changes in LV structure and function when accompanied by hypertension. These findings suggest that hypertension is the main contributor to cardiac structural and functional changes in Black adults with diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Sauyeh K. Zamani, Satyam Sarma, James P. Macnamara, Linda S. Hynan, Mark J. Haykowsky, Christopher M. Hearon, Denis Wakeham, Tiffany Brazile, Benjamin D. Levine, Vlad G. Zaha, Michael D. Nelson
Article
Geriatrics & Gerontology
Jenny L. L. Gonzalez-Armenta, Jaclyn Bergstrom, Jingyun Lee, Cristina M. M. Furdui, Barbara J. J. Nicklas, Anthony J. A. Molina
Summary: This study demonstrates that diluted serum exposure is sufficient to mediate the bioenergetic benefits of behavioral interventions. The bioenergetic changes mediated by serum can differentiate between interventions, recapitulate sex differences, and improve physical function and inflammation. Metabolomics analysis identified circulating factors associated with changes in mitochondrial bioenergetics and intervention effects.
Correction
Cardiac & Cardiovascular Systems
Anthony E. Peters, Jasper Tromp, Sanjiv J. Shah, Carolyn S. P. Lam, Gregory D. Lewis, Barry A. Borlaug, Kavita Sharma, Ambarish Pandey, Nancy K. Sweitzer, Dalane W. Kitzman, Robert J. Mentz
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Robert J. Mentz, Stephen A. Brunton, Janani Rangaswami
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Zaira Aversa, Thomas A. White, Amanda A. Heeren, Cassondra A. Hulshizer, Dominik Saul, Xu Zhang, Anthony J. A. Molina, Leanne M. Redman, Corby K. Martin, Susan B. Racette, Kim M. Huffman, Manjushri Bhapkar, Sundeep Khosla, Sai Krupa Das, Roger A. Fielding, Elizabeth J. Atkinson, Nathan K. Lebrasseur
Summary: This study investigated the effects of calorie restriction (CR) on cellular senescence markers in young-to-middle-aged individuals. The findings showed that CR significantly reduced the concentrations of senescence biomarkers and had predictive effects on metabolic parameters such as insulin resistance and resting metabolic rate. Furthermore, RNA sequencing data indicated a reduction in senescence-related gene expression in response to CR. These results contribute to the understanding of CR's effects on human aging and its association with metabolic health.
