期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 143, 期 29, 页码 10902-10909出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c06697
关键词
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资金
- National Natural Science Foundation of China [21971059, 21702056]
- National Program for Thousand Young Talents of China
- Fundamental Research Funds for the Central Universities
- Research Grants Council of Hong Kong [HKUST 16302418]
Researchers reported a catalytic enantioselective hydroboration of silyl enol ethers (SEEs) using two new chiral phosphine ligands, featuring mild reaction conditions and a broad substrate scope.
The asymmetric hydroboration of alkenes has proven to be among the most powerful methods for the synthesis of chiral boron compounds. This protocol is well suitable for activated alkenes such as vinylarenes and alkenes bearing directing groups. However, the catalytic enantioselective hydroboration of 0-substituted alkenes has remained unprecedented. Here we report a R-hcatalyzed enantioselective hydroboration of silyl enol ethers (SEEs) that utilizes two new chiral phosphine ligands we developed. This approach features mild reaction conditions and a broad substrate scope as well as excellent functional group tolerance, and enables highly efficient preparation of synthetically valuable chiral borylethers.
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