Article
Surgery
Andrew A. Angus, Lindsey N. July, Patrick M. McCarthy, Nola D. Shepard, Jason M. Rall, Jason S. Radowsky
Summary: This study aimed to compare the efficacy of a novel silicon dioxide-based hemostatic matrix (HM) with the current military standard Quikclot Combat Gauze (QCG). The results showed that there were no significant differences between the two products in terms of survival rate, hemostasis, blood loss, and arterial patency. The study suggested that this new hemostatic matrix could be used for surgical or topical hemostasis applications and further developed for battlefield trauma implementation.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Critical Care Medicine
Melissa Linskey Dougherty, Jenelle M. Izer, Allen R. Kunselman, John S. Oh, Kai Chi, Caini Chen, Jeffrey M. Catchmark, Scott B. Armen
Summary: This study investigated the use of a novel starch and chitosan hemostatic foam in an animal model. The results showed that the use of this foam for hemostasis significantly improved survival rates and improved trends in hemodynamics and laboratory data.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Engineering, Biomedical
Xiaoli Jia, Chao Hua, Fengbo Yang, Xiaoxiao Li, Peng Zhao, Feifan Zhou, Yichi Lu, Hao Liang, Malcolm Xing, Guozhong Lyu
Summary: Researchers have developed a biocompatible hemostatic system with thermoregulatory properties that can effectively stop bleeding in extreme temperature environments. The system combines a nanosilica aerogel-coated gauze with a layer-by-layer structure. The modified dressing showed significantly reduced hemostatic time and blood loss compared to normal gauze in animal experiments. Additionally, the dressing exhibited dual-functional thermal management in both hot and cold environments. This research has potential applications in both normal and extreme temperature conditions.
BIOACTIVE MATERIALS
(2023)
Article
Emergency Medicine
Yi-jun Jia, Wen-qiong Du, Zhao-wen Zong, Ren-qing Jiang, Xin Zhong, Zhao Ye, Tan-shi Li, Hao-yang Yang, Li-ping Xiao, Jie Fan
Summary: This study observed the hemostatic effects of bio-zeolite gauze (BZG) and QuikClot Combat Gauze (QCG) on major bleeding in rabbits acutely exposed to high altitude. The results showed that BZG and QCG were more effective than ordinary gauze in controlling bleeding at lower altitude. At higher altitude, the hemostatic effects of BZG did not decrease significantly, while those of ordinary gauze and QCG decreased significantly.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Chemistry, Applied
Huaying He, Caixia Sun, Yunxiang Weng, Hongjian Huang, Peng Ni, Yan Fang, Renfeng Xu, Zhengchao Wang, Haiqing Liu
Summary: A novel chitosan-catechol hemostatic gauze with impressive hemostatic performance on rat injuries has been developed through surface modification, demonstrating biodegradability and non-cytotoxicity while integrating three structure and function effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Wenzhao Zhang, Jianzhou Wu, Lisha Yu, Hao Chen, Dan Li, Chaojie Shi, Liping Xiao, Jie Fan
Summary: By modifying the surface of hydrophilic zeolite gauze with a paraffin coating, a hydrophobic dressing, PZ-Gauze, was prepared to reduce adhesion and blood loss without compromising coagulation activity. Unlike traditional gauze procoagulant theories, the hydrophobic modification did not affect the procoagulant performance, demonstrating a new approach to improving wound dressings.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Xiaojie Sun, Na Li, Xiaolei Wang, Yuzhi Mu, Chang Su, Xin Cong, Xiaoye Wang, Feifei Wu, Guangsheng Wu, Xiguang Chen, Chao Feng
Summary: In this study, a hybrid hemostatic gauze (MG-PEG) was prepared by template method for hemorrhage control. It exhibited superior hemostatic performance and wider indications range for practical application.
BIOMATERIALS ADVANCES
(2022)
Article
Critical Care Medicine
Kimberly A. Gerling, Alexander J. Kersey, Alexis L. Lauria, John A. Mares, Justin D. Hutzler, Paul W. White, Biebele Abel, David M. Burmeister, Brandon Propper, Joseph M. White
Summary: This study compared next-generation hemostatic agents with the current military standard hemostatic dressing in a translational swine model of vascular injury and coagulopathy. The results showed that most novel hemostatic agents demonstrated comparable efficacy to the current military standard.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Multidisciplinary Sciences
Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang, Yang Gao, Wei Chen, Wen Zhang, Yunxiang Weng, Zhengchao Wang, Haiqing Liu
Summary: The authors develop a modified cotton gauze with a catechol compound featuring a flexible long hydrophobic alkyl chain, which shows excellent hemostatic performance.
NATURE COMMUNICATIONS
(2022)
Review
Multidisciplinary Sciences
Ruonan Dong, Hualei Zhang, Baolin Guo
Summary: Non-compressible hemorrhage control is a significant challenge in civilian and battlefield situations, leading to a majority of traumatic injury deaths. In recent years, the demand for hemostatic materials for non-compressible hemorrhage control has increased, resulting in the development of commercialized products. However, these products have limitations, and researchers are working on developing more effective materials.
NATIONAL SCIENCE REVIEW
(2022)
Article
Medicine, General & Internal
Hong Du, Dong Zhang, Guodong Song, Xianlei Zong, Xiaolei Jin
Summary: This study evaluated the hemostatic effect of soluble hemostatic gauze in facial contouring surgery, showing significant impact on intraoperative blood loss and total postoperative drainage volume in mandibular angle ostectomy procedures. However, it did not have a significant effect on operation time, 24-hour postoperative drainage volume, and postoperative drainage time.
Article
Nanoscience & Nanotechnology
Lisha Yu, Hongliang Zhang, Liping Xiao, Jie Fan, Tanshi Li
Summary: In this study, a bio-inorganic hybrid hemostat with significant hemostatic performance was designed and validated in an animal model, showing potential applications in battlefield and traffic accident medicine.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Yuting Shi, Xiaoquan Ding, Yufei Cao, Haicun Zhou, Wenwen Yu, Mingsheng Liu, Juanjuan Yin, Hongbin Liu, Jingjing Wang, Congshu Huang, Chenliang Gong, Hua Wei, Guanghui Zhao
Summary: Thrombin, a serine protease used as a local hemostatic agent, faces challenges in clinical applications due to its sensitivity to the environment, instability, easy inactivation, and low bioavailability. In this study, six ion/thrombin hybrid microflowers and two thrombin/MOF were synthesized to explore an efficient technique for biomimetic mineralized thrombin. Among them, Zn-HNFs-G showed good hemostatic effect and maintained high enzymatic activity under high-temperature conditions, while Fe-HNFs-G, Thrombin@ZIF-8-G, and Thrombin@MAF-7-G had negligible enzyme protection.
BIOMATERIALS SCIENCE
(2021)
Article
Engineering, Biomedical
Changchang Kong, Shijunyin Chen, Xianjin Wang, Chengtao Hu, Bing Li, Renjie Fu, Jianfa Zhang
Summary: A novel hemostatic polysaccharide hemoadhican (HD) is screened out by analyzing the rheological properties of screened material mixed blood sludges. HD achieves more effective hemostasis in animal models and exhibits excellent biodegradability and hemocompatibility.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Mateo Pineda, Laura Lorena Cardenas, Javier Navarro, Diana Marcela Sanchez-Palencia, Rocio del Pilar Lopez-Panqueva, Juan Manuel Perez, Juan Carlos Briceno
Summary: The study demonstrated the feasibility and effectiveness of a small intestinal submucosa (SIS) plug to reduce and stop bleeding after percutaneous biopsies in both healthy and coagulopathic in vivo models. The plug showed minimal inflammatory reaction and effectively reduced blood loss, indicating its potential as a safer alternative for patients undergoing biopsies.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Changzheng He, Zhenyu Zou, Shaoyou Xia, Xiaowei Xing, Shidong Hu, Zilong Hu, Yuxuan Li, Songyan Li, Hongliang Zhang, Yu Yang, Yichen Liu, Xiaolei Xu, Boyan Liu, Yufeng Wang, Yingxin Xu, Xiaohui Du
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Genetics & Heredity
Bingzhou Guo, Hongliang Zhang, Jinliang Wang, Rilige Wu, Junyan Zhang, Qiqin Zhang, Lu Xu, Ming Shen, Zhibo Zhang, Fangyan Gu, Weiliang Zeng, Xiaodong Jia, Chengliang Yin
Summary: This study investigated the role of m(6)A RNA methylation regulators and m(6)A-related genes in predicting the prognosis of early lung adenocarcinoma (LUAD). A three-gene signature risk prognostic model was constructed and validated in training and test sets, showing potential as a reliable prognostic indicator for LUAD patients, with YTHDC2 being identified as a crucial gene in the risk score model.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Hongliang Zhang, Lei Zhao, Songyan Li, Jing Wang, Cong Feng, Tanshi Li, Xiaohui Du
Summary: Dysregulation of LncRNA and the tumor microenvironment play a crucial role in colon cancer progression, with the potential to be explored for prognostic biomarkers. A m6A-TME-LM model was constructed using lasso Cox regression analysis, showing promising prognostic efficacy in different subgroups of colon cancer patients. The four lncRNAs identified in the model were associated with overall survival and tumor development, indicating their potential as prognostic markers for colon cancer.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)