Specific Interactions and Environment Flexibility Tune Protein Stability under Extreme Crowding

Polyanions Cause Protein Destabilization Similar to That in Live Cells

(2021) Therese Sörensen et al.   BIOCHEMISTRY

Stabilizing or Destabilizing: Simulations of Chymotrypsin Inhibitor 2 under Crowding Reveal Existence of a Crossover Temperature

(2021) Stepan Timr et al.   Journal of Physical Chemistry Letters

Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions

(2021) Xiangfei Song et al.   ACS Chemical Biology

The Unfolding Journey of Superoxide Dismutase 1 Barrels under Crowding: Atomistic Simulations Shed Light on Intermediate States and Their Interactions with Crowders

(2020) Stepan Timr et al.   Journal of Physical Chemistry Letters

Stability Effect of Quinary Interactions Reversed by Single Point Mutations

(2019) David Gnutt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanics of Protein Adaptation to High Temperatures

(2017) Guillaume Stirnemann et al.   Journal of Physical Chemistry Letters

Influence of cosolvents, self-crowding, temperature and pressure on the sub-nanosecond dynamics and folding stability of lysozyme

(2017) S. R. Al-Ayoubi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Critical structural fluctuations of proteins upon thermal unfolding challenge the Lindemann criterion

(2017) Marina Katava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental Fluctuations and Stochastic Resonance in Protein Folding

(2016) Kapil Dave et al.   CHEMPHYSCHEM

Controlled water content for evaluation of denaturation temperature of freeze-dried enzymes

(2016) Luz María Martínez et al.   THERMOCHIMICA ACTA

Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm

(2016) Isseki Yu et al.   eLife

Recovering Protein Thermal Stability Using All-Atom Hamiltonian Replica-Exchange Simulations in Explicit Solvent

(2015) Guillaume Stirnemann et al.   Journal of Chemical Theory and Computation

Hierarchical molecular dynamics of bovine serum albumin in concentrated aqueous solution below and above thermal denaturation

(2015) Marco Grimaldo et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crowding effects on the temperature and pressure dependent structure, stability and folding kinetics of Staphylococcal Nuclease

(2014) M. Erlkamp et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Residue level quantification of protein stability in living cells

(2014) W. B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cosolvent Effects on Protein Stability

(2013) Deepak R. Canchi et al.   Annual Review of Physical Chemistry

Polymer crowders and protein crowders act similarly on protein folding stability

(2013) Huan-Xiang Zhou   FEBS LETTERS

Effect of glycerol–water binary mixtures on the structure and dynamics of protein solutions

(2013) Pavan K. GhattyVenkataKrishna et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Perspective: Reaches of chemical physics in biology

(2013) Martin Gruebele et al.   JOURNAL OF CHEMICAL PHYSICS

Reduced Native State Stability in Crowded Cellular Environment Due to Protein–Protein Interactions

(2013) Ryuhei Harada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impact of reconstituted cytosol on protein stability

(2013) M. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, construction and calibration of a portable multi sample DTA setup

(2013) Luz María Martínez et al.   THERMOCHIMICA ACTA

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

(2011) A. Dhar et al.   BIOPHYSICAL JOURNAL

Variable Interactions between Protein Crowders and Biomolecular Solutes Are Important in Understanding Cellular Crowding

(2011) Michael Feig et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Replica Exchange with Solute Scaling: A More Efficient Version of Replica Exchange with Solute Tempering (REST2)

(2011) Lingle Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein Crowding Tunes Protein Stability

(2011) Andrew C. Miklos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dependence of Protein Folding Stability and Dynamics on the Density and Composition of Macromolecular Crowders

(2010) Jeetain Mittal et al.   BIOPHYSICAL JOURNAL

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm

(2010) Sean R. McGuffee et al.   PLoS Computational Biology

Effect of Dimerization on the Stability and Catalytic Activity of Dihydrofolate Reductase from the HyperthermophileThermotoga maritima

(2009) E. Joel Loveridge et al.   BIOCHEMISTRY

CHARMM Additive All-Atom Force Field for Acyclic Polyalcohols, Acyclic Carbohydrates, and Inositol

(2009) Elizabeth R. Hatcher et al.   Journal of Chemical Theory and Computation

Computing protein stabilities from their chain lengths

(2009) K. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Protein folding in confined and crowded environments

(2007) Huan-Xiang Zhou   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS