Article
Chemistry, Medicinal
Saniya Jawed, C. S. Satish
Summary: The study aims to develop a pulsatile and mucoadhesive drug delivery system for the time-regulated release of an ACE inhibitor Perindopril Erbumine to counteract early morning pathology like hypertension. Matrix tablets were prepared using Eudragit RSPO, Eudragit RLPO, and HPMC K15M. The optimized formulations P1T3 and P2T8 were coated for a lag time with compression coating of HPMC K4M and encapsulated in a Eudracap (TM) capsule to provide gastric resistance. The in-vitro release data showed a pause phase followed by a release of the drug to cope with the early morning rush in blood pressure, and a sustained release afterwards.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Xianwei Yang, Menghan Wang, Ximeng Kang, Fei Mo, Peiru Si, Jia Ma, Peipei Zhang, Shaohua Zheng, Jiyu Li, Yang Wang, Qingqing Li, Jiye Zhang
Summary: Vulvar candidiasis (VVC) is a common and harmful infection in women caused by Candida species. This study focused on the potential of L-Se-methylselenocysteine (L-SeMC) and a mucoadhesive thermogel (NAC-HA thermogel) for the treatment of VVC. The L-SeMC@NAC-HA thermogel showed sustained release and prolonged retention time in vitro, as well as demonstrated good safety and significant anti-VVC effects in vivo. These findings suggest that this thermogel could be a promising therapy for the clinical treatment of VVC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Maisa Santos Fonseca, Daniela Meria Rodrigues, Ana Rita Sokolonski, Danijela Stanisic, Luiz Marcelo Tome, Aristoteles Goes-Neto, Vasco Azevedo, Roberto Meyer, Danilo Barral Araujo, Ljubica Tasic, Ricardo Dias Portela
Summary: This study evaluated the activity of Fusarium oxysporum-based silver nanoparticles (AgNPs) on Candida spp. isolated from denture stomatitis lesions and investigated their interference on biofilm formation and mechanisms of action. The results showed that AgNPs were effective against most Candida spp. and could potentially be a new therapeutic agent against oral candidiasis.
Article
Pharmacology & Pharmacy
Barbara Felin Osmari, Giovana Aime Medeiros, Jessica Brandao Reolon, Vinicius Costa Prado, Natalia Brucker, Leticia Cruz
Summary: This study aimed to develop NIFE-loaded nanocapsules for sublingual administration. The results showed that the nanocapsules exhibited small particle size, good stability, and controlled release, leading to improved bioavailability of NIFE. The nanocapsules were also found to protect NIFE from photodegradation, reduce cytotoxicity, and have no genotoxic or irritant effects. These findings suggest that the developed nanocapsules hold promise as a platform for sublingual administration of NIFE.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Letizia Angiolella
Summary: The antifungal activity of Pelargonium capitatum essential oil (PCEO) and Cymbopogon martini essential oil (CMEO) against C. albicans was evaluated, with PCEO showing higher activity and synergistic effects when used in combination with fluconazole or CMEO. Both essential oils were able to inhibit the major virulence factor of C. albicans. Further studies are needed to confirm these results.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Yu Zhang, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen
Summary: This study aimed to develop anidulafungin-loaded Human Serum Albumin nanoparticles to enhance its solubility and antifungal efficacy. The results showed that the nanoparticles improved water solubility of anidulafungin, exhibited stronger antifungal effects in vitro, and prolonged survival time in a murine model of invasive candidiasis compared to the free drug. The developed nanoparticles have the potential to improve drug administration and therapeutic outcomes for fungal diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ticiane da Rosa Pinheiro, Gabrielle Aguiar Dantas, Jean Lucas Gutknecht da Silva, Daniela Bitencourt Rosa Leal, Ricardo Barreto da Silva, Thiago Augusto de Lima Burgo, Roberto Christ Vianna Santos, Bernardo Almeida Iglesias
Summary: This study evaluated the in vitro activity of cationic porphyrins with platinum(II) complexes against Candida albicans. The results showed that 3PtTPyP exhibited excellent antifungal activity and reduced preformed biofilms effectively.
Article
Polymer Science
Kashaf Bashir, Muhammad Farhan Ali Khan, Aiyeshah Alhodaib, Naveed Ahmed, Iffat Naz, Bushra Mirza, Muhammad Khalid Tipu, Humaira Fatima
Summary: The current study focuses on the extraction and isolation of bergenin from Bergenia ciliata and the fabrication of pH-sensitive Eudragit (R) L100 polymeric nanoparticles. The optimized nanoformulation showed suitable particle size and loading capacity, and exhibited pH-responsive release potential.
Article
Biotechnology & Applied Microbiology
Cecilia Maria Cruz Falcao, Audrey Andrade, Vanderlan Nogueira Holanda, Regina Celia Bressan Queiroz de Figueiredo, Eulalia Azevedo Ximenes, Anderson Stevens Leonidas Gomes
Summary: This study demonstrates the potential of PMAA-AgNPs combined with fluconazole to inhibit fluconazole-resistant Candida albicans strains. The combination also inhibits germ tube formation, an important virulence factor.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abdulrahman Khattar, Jawad A. A. Alghafli, Mohammed A. A. Muheef, Ali M. M. Alsalem, Mohammed A. A. Al-Dubays, Hussain M. M. AlHussain, Hussain M. M. AlShoalah, Soban Q. Q. Khan, Doaa M. M. AlEraky, Mohammed M. Gad
Summary: This study aimed to investigate the antibiofilm activity and surface roughness of a 3D-printed denture base resin modified with different concentrations of zirconium dioxide nanoparticles (ZrO2 NPs). The results showed that low concentrations of ZrO2 NPs did not affect the surface roughness of the 3D-printed resins and significantly reduced Candida albicans adhesion. Therefore, these 3D-printed resins with low concentrations of nanocomposites could be used as possible materials for the prevention and treatment of denture stomatitis, due to their antibiofilm activities.
Article
Biochemistry & Molecular Biology
Ruifang Li, Mengke Tao, Shang Li, Xueqin Wang, Yanhui Yang, Lianfeng Mo, Kaidi Zhang, Ao Wei, Liang Huang
Summary: The antifungal peptide CGA-N12, derived from human chromogranin A, exhibits fungicidal activity and time-dependent inhibition against Candida tropicalis. Its internalization into cells is energy-dependent and related to peptide concentration, with effects on cell membrane integrity being concentration-dependent.
BIOCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Isabela A. P. Farias, Carlos C. L. Santos, Aline L. Xavier, Tatianne M. Batista, Yuri M. Nascimento, Jocianelle M. F. F. Nunes, Patricia M. F. Silva, Raimundo A. Menezes-Junior, Jailson M. Ferreira, Edeltrudes O. Lima, Josean F. Tavares, Marianna Sobral, Dawy Keyson, Fabio C. Sampaio
Summary: Fungal infection poses a public health concern with antifungal resistance being common in Candida albicans. Cerium oxide nanoparticles showed promising antifungal activity against Candida albicans strains without significant antioxidant effects. Acute toxicity studies in mice and brine shrimp did not reveal harmful effects, supporting the potential use of CeNP as an antifungal agent in biotechnology and biomedical applications.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mostafa A. Elbahnasawy, Amr M. Shehabeldine, Abdelrahman M. Khattab, Basma H. Amin, Amr H. Hashem
Summary: This study utilized Rothia endophytica to biosynthesize silver nanoparticles and found it exhibited significant antifungal activity against Candida albicans, disrupting cell walls and reducing cell viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Giovanna Ginestra, Teresa Gervasi, Francesca Mancuso, Federica Bucolo, Laura De Luca, Rosaria Gitto, Davide Barreca, Giuseppina Mandalari
Summary: In this study, a series of arylsulfonamide compounds were screened and the structure-activity relationship was established based on a hit compound. The antifungal activity against various Candida species was tested, and cytotoxicity was evaluated. These findings could contribute to the development of novel topical therapeutics for fungal infections.
Article
Chemistry, Multidisciplinary
Tania Lima, Stefan B. Gunnarsson, Elisabete Coelho, Dmitry Evtuguin, Alexandra Correia, Manuel A. Coimbra, Tommy Cedervall, Manuel Vilanova
Summary: This study developed a method using nanoparticles to modulate the deleterious inflammatory response caused by fungal infection. The results showed that β-Glc-PS nanoparticles can reduce the inflammatory response caused by C. albicans cells and decrease the production of reactive oxygen species. This provides a theoretical basis for the development of targeted therapy for fungal infections.
Article
Chemistry, Physical
Ahmed Alaa Kassem, Amira Mohamed Mohsen, Reham Samir Ahmed, Tamer Mohamed Essam
JOURNAL OF MOLECULAR LIQUIDS
(2016)
Article
Pharmacology & Pharmacy
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A. El-Awdan, Asmaa Badawy Darwish
CURRENT DRUG DELIVERY
(2018)
Article
Multidisciplinary Sciences
Marwa H. Asfour, Amira M. Mohsen
JOURNAL OF ADVANCED RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Aliaa N. ElMeshad, Amira M. Mohsen
Review
Pharmacology & Pharmacy
Amira Mohamed Mohsen
CURRENT DRUG TARGETS
(2019)
Article
Pharmacology & Pharmacy
Amira Mohamed Mohsen, Abeer Salama, Ahmed Alaa Kassem
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Medicinal
Amira Mohamed Mohsen, Mostafa Mohamed Younis, Abeer Salama, Asmaa Badawy Darwish
Summary: This study aimed to develop CoQ10-loaded cubosomes to enhance its oral delivery and hepatoprotective activity. The developed cubosomes showed good drug entrapment efficiency, nanometric dimensions, sustained release of CoQ10, and potential in enhancing the hepatoprotective activity of CoQ10.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Marwa Hasanein Asfour, Abeer A. A. Salama, Amira Mohamed Mohsen
Summary: The study successfully prepared ATRA-loaded CTLHNs, demonstrating better stability and effectiveness in DN treatment, validated through in vitro and in vivo experiments.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ahmed Alaa Kassem, Abeer Salama, Amira Mohamed Mohsen
Summary: The present study successfully developed dorzolamide HCl loaded cationic nanoemulsions (CNEs) for enhanced ocular delivery. The optimized formulation exhibited sustained drug release and enhanced lowering effect of intraocular pressure in animal experiments. The results indicated the potential of this nanoemulsion for successful ocular delivery with improved therapeutic efficacy and safety.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amira Mohamed Mohsen, Yosra Ibrahim Nagy, Amr M. Shehabeldine, Mona M. Okba
Summary: Natural medicines formulated using nanotechnology-based systems, such as thymol-loaded cationic polymeric nanoparticles, have great potential in enhancing wound healing and skin retention. In this study, thymol-loaded cationic polymeric nanoparticles were developed, which showed high entrapment efficiency, small particle size, and positive zeta potential. The incorporation of these nanoparticles into hydrogels further improved skin retention and wound closure. Moreover, the nanoparticles-based hydrogels demonstrated the ability to combat MRSA infection in a murine skin model.
Article
Pharmacology & Pharmacy
Amira Mohamed Mohsen, Abeer A. A. Salama, Marwa Hasanein Asfour
Summary: Lamotrigine (LTG) cubosomes loaded in a thermosensitive in situ gel were developed to enhance drug absorption across the nasal mucosal membrane. The cubosomes exhibited good entrapment efficiency, particle size, and zeta potential. The LTG cubogel showed superior antiepileptic efficacy compared to LTG cubosomes.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Amira Mohamed Mohsen, Mona Mahmoud AbouSamra, Shaimaa Ahmed ElShebiney
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2017)
Article
Pharmacology & Pharmacy
Mohamed S. El-Ridy, Abd-Elhameed A. El-Shamy, A. Ramadan, Rehab F. Abdel-Rahman, Gehanne A. Awad, Ahmed El-Batal, Amira M. Mohsen, Asmaa B. Darwish
BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH
(2015)
Article
Chemistry, Medicinal
Amira Mohamed Mohsen, Marwa Hasanein Asfour, Abeer A. A. Salama
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2017)