Opalescence Measurements: Improvements in Fundamental Knowledge, Identifying Sources of Analytical Biases, and Advanced Applications for the Development of Therapeutic Proteins

A single molecular descriptor to predict solution behavior of therapeutic antibodies

(2020) Jonathan S. Kingsbury et al.   Science Advances

Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1

(2019) Yue Hu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of native reversible self-association of a monoclonal antibody mediated by Fab-Fab interaction

(2019) Lorenzo Gentiluomo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Arginine suppresses opalescence and liquid–liquid phase separation in IgG solutions

(2018) Shogo Oki et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis

(2018) Mandi M. Hopkins et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Elucidating the weak protein-protein interaction mechanisms behind the liquid-liquid phase separation of a mAb solution by different types of additives

(2017) Guoliang Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Measurement differences between turbidity instruments, and their implications for suspended sediment concentration and load calculations: A sensor inter-comparison study

(2017) A. Rymszewicz et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

A review of the principles of turbidity measurement

(2017) Ben GB Kitchener et al.   PROGRESS IN PHYSICAL GEOGRAPHY

Limitations of turbidity process probes and formazine as their calibration standard

(2016) Marvin Münzberg et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Trimerization Dictates Solution Opalescence of a Monoclonal Antibody

(2016) Teng-Chieh Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions

(2015) Reza Esfandiary et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Opalescence in Monoclonal Antibody Solutions and Its Correlation with Intermolecular Interactions in Dilute and Concentrated Solutions

(2015) Ashlesha S. Raut et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Liquid–Liquid Phase Separation in a Dual Variable Domain Immunoglobulin Protein Solution: Effect of Formulation Factors and Protein–Protein Interactions

(2015) Ashlesha S. Raut et al.   MOLECULAR PHARMACEUTICS

Prediction of colloidal stability of high concentration protein formulations

(2014) Patrick Garidel et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation

(2011) Bruce D. Mason et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phase Separation of an IgG1 Antibody Solution under a Low Ionic Strength Condition

(2010) Hirotaka Nishi et al.   PHARMACEUTICAL RESEARCH

Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation

(2009) Branden A. Salinas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Shaken, Not Stirred: Mechanical Stress Testing of an IgG1 Antibody

(2008) Sylvia Kiese et al.   JOURNAL OF PHARMACEUTICAL SCIENCES