Article
Cardiac & Cardiovascular Systems
Hilal Khan, Amelia Rudd, David T. Gamble, Alice M. Mezincescu, Lesley Cheyne, Graham Horgan, Neeraj Dhaun, David E. Newby, Dana K. Dawson
Summary: This study investigates if the renin-angiotensin and endothelin-1 response pathways in patients with takotsubo cardiomyopathy follow the same pattern of recovery as the left ventricular ejection fraction. It is found that despite the normalization of the left ventricular ejection fraction, there is long-term maladaptive activation of the renin-angiotensin system in patients with takotsubo cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Clinical Neurology
Sabrina Lasini Gruhl, Jun Su, Wei Chong Chua, Kon Voi Tay
Summary: Based on the systematic review, most patients with TC demonstrate a resolution of cardiac function, and neurosurgical intervention can improve the chance of survival.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Stina Ahlstrom, Johan Ahlner, Anna K. Joensson, Henrik Green
Summary: This study evaluates the effects of beta-hydroxybutyrate (BHB) analysis on different causes of death. The results indicate that BHB analysis is instrumental in detecting alcoholic ketoacidosis and acidosis, but does not change the diagnosis of diabetes ketoacidosis and hypothermia.
Article
Biology
Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn P. van den Heuvel, Amy F. D. Howard, Istvan N. Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A. L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars, Karla L. Miller
Summary: The Digital Brain Bank is a data release platform that provides open access to curated, multimodal post-mortem neuroimaging datasets. It includes datasets for detailed neuroanatomical investigations, comparative neuroanatomy, and neuropathology investigations. The platform's first data release includes high-resolution whole-brain diffusion MRI datasets for structural connectivity investigations, making it one of the largest studies in neurodegeneration.
Article
Cardiac & Cardiovascular Systems
Feng Dong, Liya Yin, Hamayak Sisakian, Tatevik Hakobyan, Lacey S. Jeong, Hirva Joshi, Ellianna Hoff, Selena Chandler, Geetika Srivastava, Abdur Rahman Jabir, Kelly Kimball, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, Parisa Shabani, Lindsay Shockling, Thomas Pucci, Karlina Kegecik, Christopher Kolz, Zhenyu Jia, William M. Chilian, Vahagn Ohanyan
Summary: This study found that coronary microvascular dysfunction plays a key role in the development of Takotsubo syndrome, and abnormalities in flow regulation between the left ventricular apex and base contribute to ventricular dysfunction. Normalization of blood flow between these two regions restores ventricular function.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
John E. Madias
Summary: The management of TTS is currently empirical and supportive, with therapies being extrapolated from principles used for other cardiovascular diseases. While the pathophysiology of TTS remains elusive, treatment strategies may be targeted at addressing common consequences shared with coronary artery disease and other cardiovascular disorders. New therapeutic hypotheses are being considered based on animal studies and limited patient applications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Roger Esmel-Vilomara, Lucia Riaza, Paola Dolader, Anna Sabate-Rotes, Ferran Roses-Noguer, Ferran Gran
Summary: This study aimed to investigate the role of cardiac magnetic resonance imaging (CMR) and endomyocardial biopsy (EMB) in detecting inflammatory cardiomyopathies in infants with new-onset heart failure. The findings showed that both CMR and EMB can detect inflammation, but CMR is not effective in differentiating between different etiologies.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Michiaki Nagai, Carola Yvette Foerster, Keigo Dote
Summary: In this review, the role of insular cortex as an important moderator of the human brain-heart axis in association with sex hormones is discussed, and the current knowledge regarding the sex-specific neuroanatomy in Takotsubo syndrome (TTS) is summarized.
Article
Cardiac & Cardiovascular Systems
Albert Topf, Moritz Mirna, Nina Bacher, Vera Paar, Lukas J. Motloch, Bernhard Ohnewein, Robert Larbig, Janine Grueninger, Uta C. Hoppe, Michael Lichtenauer, Rudin Pistulli
Summary: Among patients with diagnosed cardiomyopathy, the differentiation between Takotsubo cardiomyopathy (TTC) and ischemic cardiomyopathy (ICMP) or dilated cardiomyopathy (DCMP) can be challenging. Biomarkers such as sST-2 may play a crucial role in predicting and distinguishing these conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Kenji Rowel Q. Lim, Douglas L. Mann, Tsuneaki Kenzaka, Tomohiro Hayashi
Summary: Takotsubo syndrome (TTS) is characterized by the temporary dysfunction of the heart with abnormal regional wall motion, primarily caused by a sudden increase in catecholamines. Inflammation plays a crucial role in determining patient outcomes and the early pathogenesis of the disorder.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Trisha Singh, Hilal Khan, David T. Gamble, Caroline Scally, David E. Newby, Dana Dawson
Summary: “Takotsubo syndrome is an acute condition with transient dysfunction of the left ventricle, which is challenging to differentiate from acute myocardial infarction. Recent studies have shown that patients with this syndrome have persistent cardiac dysfunction and limiting symptoms. They also have a substantial burden of morbidity and mortality, similar to patients with acute coronary syndrome. The underlying pathophysiology of this condition remains unclear, and further research is needed to inform evidence-based management strategies.”
Review
Cardiac & Cardiovascular Systems
Fawzi Zghyer, W. Savindu Pasan Botheju, Joshua E. Kiss, Erin D. Michos, Mary C. Corretti, Monica Mukherjee, Allison G. Hays
Summary: Stress cardiomyopathy is a reversible syndrome caused by myocardial injury, usually occurring in response to a stressful event. Neurocardiogenic mechanisms may play an important role in its pathophysiology. Although initially considered relatively benign, research has brought attention to its association with cardiovascular complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Estefania Martinez-Barrios, Simone Grassi, Maria Brion, Rocio Toro, Sergi Cesar, Jose Cruzalegui, Monica Coll, Mireia Alcalde, Ramon Brugada, Andrea Greco, Maria Luisa Ortega-Sanchez, Eneko Barberia, Antonio Oliva, Georgia Sarquella-Brugada, Oscar Campuzano
Summary: In the field of forensic medicine, molecular autopsy is a genetic analysis performed after a comprehensive forensic autopsy to uncover the cause of death in cases that remain unexplained. This typically occurs in young individuals and is suspected to originate from an underlying inherited arrhythmogenic syndrome. Next-generation sequencing can identify potentially pathogenic rare genetic variants in up to 25% of sudden death cases in young individuals. Early identification of these pathogenic genetic alterations can help prevent malignant arrhythmias and sudden death in at-risk relatives. However, there are challenges in interpreting and translating genetic findings into clinical practice.
FRONTIERS IN MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Simone Grassi, Oscar Campuzano, Francesca Cazzato, Minica Coll, Alessandra Puggioni, Massimo Zedda, Vincenzo Arena, Anna Iglesias, Georgia Sarquella-Brugada, Vilma Pinchi, Ramon Brugada, Antonio Oliva
Summary: Takotsubo syndrome (TTS) is a cardiac syndrome characterized by transient left ventricular systolic dysfunction in the absence of significant obstructive coronary artery disease. The diagnosis of TTS at autopsy is challenging due to the lack of characteristic macroscopic or microscopic findings. A systematic review of the literature identified recurring but not pathognomonic microscopic features of TTS, such as contraction band necrosis and non-specific inflammatory changes. Careful evaluation of the patient's history, autopsy data, and post-mortem genetic results is necessary to exclude other causes in cases of TTS-related sudden death.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Neurosciences
Yanaika S. Hok-A-Hin, Anke A. Dijkstra, Alberto Rabano, Jeroen J. Hoozemans, Lucia Castillo, Harro Seelaar, John C. van Swieten, Yolande A. L. Pijnenburg, Charlotte E. Teunissen, Marta Del Campo
Summary: This study found increased levels of APOL1 in FTLD post-mortem brain tissue, regardless of the pathological subtypes. APOL1 was mainly expressed in neuronal and glial cells, but did not co-localize with pTau or pTDP-43. However, the levels of APOL1 in CSF were comparable between FTD patients and controls, and between pathological subtypes.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Medicine, Legal
Francesco Paolo Busardo, Luigi Tritapepe, Angelo Montana, Francesca Indorato, Simona Zaami, Guido Romano
FORENSIC SCIENCE INTERNATIONAL
(2015)
Article
Medicine, Legal
Francesca Indorato, Yoshihiro J. Akashi, Carlo Rossitto, Cataldo Raffino, Giovanni Bartoloni
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2015)
Article
Medicine, Legal
Francesca Indorato, Aldo Liberto, Caterina Ledda, Guido Romano, Nunziata Barbera
FORENSIC SCIENCE INTERNATIONAL
(2016)
Article
Medicine, Legal
Nunziata Barbera, Angelo Montana, Francesca Indorato, Nadia Arbouche, Guido Romano
FORENSIC SCIENCE INTERNATIONAL
(2016)
Article
Medicine, Legal
Francesca Indorato, Guido Romano, Nunziata Barbera
FORENSIC SCIENCE INTERNATIONAL
(2016)
Article
Medicine, Legal
Nunziata Barbera, Angelo Montana, Francesca Indorato, Nadia Arbouche, Guido Romano
JOURNAL OF FORENSIC SCIENCES
(2017)
Article
Medicine, Legal
Nunziata Barbera, Francesca Indorato, Angelo Spitaleri, Andrea Bosco, Maurilio Carpinteri, Francesco Paolo Busardo, Guido Romano
AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
(2014)
Article
Medicine, Legal
Nunziata Barbera, Francesco Paolo Busardo, Francesca Indorato, Guido Romano
FORENSIC SCIENCE INTERNATIONAL
(2013)
Article
Medicine, Legal
Francesca Indorato, Cataldo Raffino, Filippa Maria Tropea, Nunziata Barbera, Angela Grieco, Giovanni Bartoloni
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2014)
Article
Medicine, Legal
Nunziata Barbera, Marco Fisichella, Andrea Bosco, Francesca Indorato, Giorgio Spadaro, Guido Romano
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2013)
Article
Medicine, Legal
Edoardo Scalici, Francesca Indorato, Francesca Portelli, Tommaso Savi, Emiliano Maresi, Francesco P. Busardo
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2014)
Article
Pharmacology & Pharmacy
F. P. Busardo, S. Zaami, G. Baglio, F. Indorato, A. Montana, N. Giarratana, C. Kyriakou, E. Marinelli, G. Romano
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2015)
