期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 15, 页码 10235-10248出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00981
关键词
-
资金
- National Research Foundation of Korea [NRF2018R1A6A1A03023718, NRF-2020R1A2C2005961]
A domino Michael-aldol double elimination route was utilized to synthesize indolizines with two different acyl groups at the C5 and C7 positions, using chromone as a two-carbon unit for the first time. Various analogues were easily obtained in good yields under metal-free and eco-friendly conditions. Manipulation of the resulting products led to the synthesis of novel indolizine-heterocycle adducts that are not easily accessible by other methods.
A domino Michael-aldol double elimination route to indolizines having two different acyl groups at the C5 and C7 positions is described where chromone is employed as a two-carbon unit for the synthesis of a pyridine moiety for the first time. Various analogues were readily accessed in good yields under metal-free and eco-friendly conditions. Further manipulation of the resulting products allowed entry to novel indolizine-heterocycle adducts, which are difficult to access by other methods.
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