期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 50, 期 10, 页码 1067-1071出版社
WILEY
DOI: 10.1111/jop.13243
关键词
adenoid ameloblastoma; BRAF; genetics; KRAS; mutations; odontogenic tumors
资金
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Molecular analysis revealed that adenoid ameloblastoma lacks BRAF and KRAS mutations, supporting its distinction from adenomatoid odontogenic tumor and ameloblastoma at the molecular level.
Background Adenoid ameloblastoma is a rare epithelial neoplasm, histologically characterized by the presence of ameloblastoma-like features, duct-like structures, epithelial whorls, and cribriform architecture. Dentinoid material is usually present. Some advocate adenoid ameloblastoma is an ameloblastoma variant. However, there are overlapping features not only with ameloblastoma, but also with adenomatoid odontogenic tumor. Most ameloblastomas are characterized by the presence of BRAF p.V600E mutations and adenomatoid odontogenic tumors harbor signature KRAS mutations. The molecular features of adenoid ameloblastoma remain unknown. Methods Nine adenoid ameloblastoma cases were screened by TaqMan allele-specific qPCR to assess BRAF p.V600E, ameloblastoma signature mutation, and KRAS p.G12V and p.G12R, adenomatoid odontogenic tumor signature mutations. Results BRAF and KRAS mutations were not detected in any of the adenoid ameloblastoma cases. Conclusion The molecular results support adenoid ameloblastoma as an entity distinct from adenomatoid odontogenic tumor and ameloblastoma.
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