Article
Nutrition & Dietetics
Xinli Song, Letao Chen, Senmao Zhang, Yiping Liu, Jianhui Wei, Tingting Wang, Jiabi Qin
Summary: The study found that gestational diabetes mellitus and high maternal triglyceride levels independently increased the risk of macrosomia, and collectively acted as significant mediators in the relationship between pre-pregnancy overweight/obesity and macrosomia.
Article
Endocrinology & Metabolism
Dingyu Cui, Wen Yang, Ping Shao, Jing Li, Peng Wang, Junhong Leng, Shuo Wang, Enqing Liu, Juliana C. N. Chan, Zhijie Yu, Gang Hu, Xilin Yang
Summary: Prepregnancy overweight/obesity was synergistically associated with an increased risk of macrosomia in Chinese women who also engaged in passive smoking during pregnancy, with the majority of the association remaining unchanged by hyperglycemia during pregnancy.
Article
Endocrinology & Metabolism
Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D. Stephen Charnock-Jones, Deborah A. Lawlor, Gordon C. S. Smith
Summary: The study found that a metabolite ratio originally developed for predicting FGR also accurately predicts LGA birth weight and is inversely associated with birth weight across the whole range.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Dan Wu, Jianzheng Zhu, Xiulian Wang, Huiqing Shi, Yanyan Huo, Meiyan Liu, Fanfan Sun, Hongyan Lan, Chong Guo, Honghua Liu, Tingting Li, Lian Jiang, Xiangying Hu, Tianshu Li, Jing Xu, Guoying Yao, Guowei Zhu, Guangjun Yu, Jinjin Chen
Summary: This study found that rapid increase in BMI during early infancy in former SGA newborns leads to a persistent risk of obesity, highlighting the importance of controlling energy intake and closely monitoring BMI changes for optimal management.
FRONTIERS IN PEDIATRICS
(2021)
Article
Acoustics
Jose R. Duncan, Linda Odibo, Elizabeth A. Hoover, Anthony O. Odibo
Summary: The NICHD and FMF standards may increase the detection rate of LGA compared to the Hadlock chart. However, they are poor predictors for adverse neonatal outcomes.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xiaodi Zhao, Nana Li, Runping Jia, Shumin Chen, Ling Wang
Summary: During pregnancy, factors such as gestational diabetes mellitus (GDM), maternal weight gain, and pre-pregnancy body mass index may impact the physical development of newborns. In women with GDM, gestational age is correlated with abnormal physical development in neonates.
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Obstetrics & Gynecology
Nirmala Chandrasekaran
Summary: Fetal macrosomia and large for gestational age (LGA) are associated with adverse outcomes for both mothers and babies, such as increased rates of cesarean section and other complications. While labor induction is suggested as a way to reduce these risks, current guidelines do not recommend routine induction in this population.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Multidisciplinary Sciences
Teresa M. MacDonald, Alice J. Robinson, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Lucy M. Kennedy, Stephen Tong, Susan P. Walker
Summary: The study found that fetuses with accelerated growth velocity between 28-36 weeks of gestation are at higher risk of shoulder dystocia, even if they are not large for gestational age. Accelerated fetal growth velocities may predict shoulder dystocia risk better than the commonly used threshold of 36-week estimated fetal weight >95th centile.
Article
Obstetrics & Gynecology
Duna Trobo, Cecilia Garcia, Marta Martinez, Ines Rodriguez, Maria Rojo, Sonsoles Moreno, Gonzalo Nozaleda, Ana Solis, Laura Perez, Miguel Caballero, Elena Ceballos, Maria T. Navarro, Federico Mariano Perez-Milan
Summary: The transfer of frozen-thawed embryos is associated with an increased risk of large for gestational age (LGA), regardless of other factors.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Julie M. Petersen, Jennifer A. Hutcheon, Lisa M. Bodnar, Samantha E. Parker, Katherine A. Ahrens, Martha M. Werler
Summary: This study investigated the relationship between gestational weight gain (GWG) and the size of infants at birth, and found that weight maintenance during the second and third trimesters may be associated with better birth weight for gestational age. However, it is unclear how this can be achieved (e.g., through diet and exercise interventions) due to the observational design of the study.
Article
Nutrition & Dietetics
Xinli Song, Jing Shu, Senmao Zhang, Letao Chen, Jingyi Diao, Jinqi Li, Yihuan Li, Jianhui Wei, Yiping Liu, Mengting Sun, Tingting Wang, Jiabi Qin
Summary: This study reveals the impact of maternal pre-pregnancy BMI status on the risk of macrosomia and LGA through the mediation of GDM. Being overweight or obese before pregnancy increases the risk of macrosomia and LGA independently as well as partially mediated by GDM.
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Eric O. Ohuma, Chia-Jung Chang, Elizabeth A. Hazel, Judith Yargawa, Yemisrach B. Okwaraji, Ellen Bradley, Adrienne Gordon, Jessica Sexton, Harriet L. S. Lawford, Enny S. Paixao, Ila R. Falcao, Sarka Lisonkova, Qi Wen, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik T. Sorensen, Luule Sakkeus, Lili Abuladze, Khalid A. Yunis, Ayah Al Bizri, Sonia Lopez Alvarez, Lisa Broeders, Aimee E. van Dijk, Fawziya Alyafei, Mai Alqubaisi, Neda Razaz, Jonas Soederling, Lucy K. Smith, Ruth J. Matthews, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Joy E. Lawn, Hannah Blencowe
Summary: In this study, the prevalence and neonatal mortality of large for gestational age (LGA) and macrosomia were compared among live births in 15 countries. The results showed that LGA babies had a lower risk of neonatal mortality compared to babies that were appropriate for gestational age (AGA), while macrosomia babies weighing over 4500 grams had a higher risk of mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Medicine, General & Internal
Sudipta Sarker Mou, Clare Gillies, Jiamiao Hu, Marianna Danielli, Bassel Hamameeh Al Wattar, Kamlesh Khunti, Bee Kang Tan
Summary: Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnancy, and it is associated with maternal and fetal complications. The HbA1c level at 24-28 weeks of pregnancy may predict the development of fetal macrosomia or large for gestational age (LGA) in women with GDM. A systematic review and meta-analysis showed that women with high HbA1c values had a higher risk of giving birth to an LGA baby. Further research is needed to evaluate the utility of HbA1c levels in predicting the delivery of a baby with fetal macrosomia or LGA in pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Xinli Song, Letao Chen, Senmao Zhang, Yiping Liu, Jianhui Wei, Mengting Sun, Jing Shu, Tingting Wang, Jiabi Qin
Summary: This study aimed to investigate the relationship between maternal pre-pregnancy overweight/obesity, high maternal triglyceride levels, and the risk of macrosomia. The results showed that overweight/obesity had a partially mediated effect on macrosomia through high triglyceride levels, with a mediation proportion of 11.1% and 3.8%, respectively.
Article
Nutrition & Dietetics
Marit Navis, Vanesa Muncan, Per Torp Sangild, Line Moller Willumsen, Pim J. Koelink, Manon E. Wildenberg, Evan Abrahamse, Thomas Thymann, Ruurd M. van Elburg, Ingrid B. Renes
Article
Obstetrics & Gynecology
Jorrit F. de Kieviet, Renee Lustenhouwer, Marsh Konigs, Ruurd M. van Elburg, Petra J. W. Pouwels, Jaap Oosterlaan
Summary: This study found that very preterm children have a more segregated network organization in the structural connectome compared to term peers, with higher smallworldness and clustering coefficient. Motor problems are associated with altered organization of the structural connectome in term born children, whereas potential compensational processes are only found for Ball Skills in very preterm children.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Nutrition & Dietetics
Andreas Kakaroukas, Marieke Abrahamse-Berkeveld, Janet E. Berrington, Richard J. Q. McNally, Christopher J. Stewart, Nicholas D. Embleton, Ruurd M. van Elburg
Summary: The FLAMINGO study aims to improve understanding of the longitudinal growth, body composition, nutritional needs, microbiome development, and neurodevelopment of LMPT infants. By recruiting 250 healthy LMPT infants and conducting an RCT, the study will provide insights into the development and feeding characteristics of LMPT infants.
FRONTIERS IN NUTRITION
(2021)
Letter
Allergy
Kim Kamphorst, Arine M. Vlieger, Berthe C. Oosterloo, Susan Waarlo, Ruurd M. van Elburg
Article
Pediatrics
Lisa M. Hortensius, Edith H. van den Hooven, Jeroen Dudink, Maria Luisa Tataranno, Ruurd M. van Elburg, Manon J. N. L. Benders
Summary: This study aims to evaluate the effect of a combination of probiotics, prebiotics, and L-glutamine on brain development in preterm infants, potentially providing new insights and safe treatment possibilities to improve brain development in preterm infants.
Review
Obstetrics & Gynecology
Nora C. Carpay, Andreas Kakaroukas, Nicholas D. Embleton, Ruurd M. van Elburg
Summary: Risk groups for lower breastfeeding rates in MLPIs include mothers with lower socioeconomic status and single-parent households. Providing more information and health care support may help improve breastfeeding rates.
BREASTFEEDING MEDICINE
(2021)
Article
Nutrition & Dietetics
Elise Mank, Eva Kontopodi, Annemieke C. Heijboer, Ruurd M. van Elburg, Kasper Hettinga, Johannes B. van Goudoever, Letty van Toledo
Summary: This study compared the effect of different techniques on the insulin concentration in donor human milk (DHM) and found that thermoultrasonication (TUS), ultraviolet-C irradiation (UV-C), and high-pressure processing (HPP) can preserve insulin in DHM. These new techniques may serve as alternatives to holder pasteurization (HoP).
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Eva Kontopodi, Sertac Arslanoglu, Urszula Bernatowicz-Lojko, Enrico Bertino, Maria Enrica Bettinelli, Rachel Buffin, Tanya Cassidy, Ruurd M. van Elburg, Corina Gebauer, Anne Grovslien, Kasper Hettinga, Ioanna Ioannou, Daniel Klotz, Radmila Mileusnic-Milenovic, Guido E. Moro, Jean-Charles Picaud, Bernd Stahl, Gillian Weaver, Johannes B. van Goudoever, Aleksandra Wesolowska
Summary: The study reveals a wide variability in milk banking practices across Europe, including practices that could further enhance the efficiency of donor human milk banking. The findings could be used as a groundwork for a global discussion on the development of evidence-based guidelines to improve these practices.
Article
Nutrition & Dietetics
Mirjam Vreugdenhil, Marjolijn D. Akkermans, Liandre F. van der Merwe, Ruurd M. van Elburg, Johannes B. van Goudoever, Frank Brus
Summary: This study found a significant prevalence of zinc deficiency among healthy 1-3-year-old children from Western European high-income countries, with no significant differences in socio-economic characteristics and dietary zinc intake between children with and without zinc deficiency.
Article
Nutrition & Dietetics
Lisa M. Hortensius, Els Janson, Pauline E. van Beek, Floris Groenendaal, Nathalie H. P. Claessens, Henriette F. N. Swanenburg de Veye, Maria J. C. Eijsermans, Corine Koopman-Esseboom, Jeroen Dudink, Ruurd M. van Elburg, Manon J. N. L. Benders, Maria Luisa Tataranno, Niek E. van der Aa
Summary: The study found that higher postnatal protein intake is important for white matter development in extremely preterm born infants, but may not necessarily improve long-term cognitive and motor development. While higher protein intake was associated with higher white matter integrity, it was also linked to lower motor scores at 2 years corrected age. However, these differences were not sustained at 5.9 years.
Article
Infectious Diseases
Tania Martins Garcia, Manon van Roest, Jacqueline L. M. Vermeulen, Sander Meisner, Jan Koster, Manon E. Wildenberg, Ruurd M. van Elburg, Vanesa Muncan, Ingrid B. Renes
Summary: This study investigated whether the effects of early life antibiotic use on the gut persist into adulthood and whether there are long-term consequences for gut functioning. The results showed that the majority of the antibiotic-induced gut effects did not persist into adulthood, but early life antibiotic use did impact later life gut functioning.
Article
Pediatrics
Emmy Van Daele, Kim Kamphorst, Arine M. Vlieger, Gerben Hermes, Christian Milani, Marco Ventura, Clara Belzer, Hauke Smidt, Ruurd M. van Elburg, Jan Knol
Summary: Study found that exposure to antibiotics in the first week of life can alter the development of the infant's fecal microbiota, with long-term deviations in relative abundance of certain taxa observed up to 1 year of age. The effects varied based on the mode of delivery.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Jill Wong, Agathe C. Foussat, Steven Ting, Enzo Acerbi, Ruurd M. van Elburg, Chua Mei Chien
Summary: This study explored the usability and feasibility of chatbot technology for collecting real-life conversation data on stress, sleep, and infant feeding from parents with newborn infants. The results showed that parents with preterm infants reported emotional stress more frequently and feeding problems more frequently than parents of term infants. Overall, the chatbot was successfully used to collect real-time conversation data from a group of 45 parents, with positive feedback on user experience.
JMIR PEDIATRICS AND PARENTING
(2021)
Review
Pediatrics
Kim Kamphorst, Emmy Van Daele, Arine M. Vlieger, Joost G. Daams, Jan Knol, Ruurd M. van Elburg
Summary: This systematic review found that the use of antibiotics in early life might increase the risk of gastrointestinal disorders later in childhood in term born children, particularly in inflammatory bowel disease and coeliac disease. Moderate evidence was also found for eosinophilic esophagitis, while no association was found with functional constipation in the first year.
BMJ PAEDIATRICS OPEN
(2021)