Discovery of 8,9-seco-ent-Kaurane Diterpenoids as Potential Leads for the Treatment of Triple-Negative Breast Cancer

Novel Agents for Metastatic Triple-Negative Breast Cancer: Finding the Positive in the Negative

(2021) Neelima Vidula et al.   Journal of the National Comprehensive Cancer Network

Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer

(2020) Hong Yao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

(2020) Antonio Marra et al.   npj Breast Cancer

Dual inhibition of Akt and ERK signaling induces cell senescence in triple-negative breast cancer

(2019) Qiang He et al.   CANCER LETTERS

AKT and ERK dual inhibitors: The way forward?

(2019) Zhe Cao et al.   CANCER LETTERS

Advances in Targeted Therapies for Triple-Negative Breast Cancer

(2019) Kelly E. McCann et al.   DRUGS

Autophagy as a molecular target for cancer treatment

(2019) Nur Mehpare Kocaturk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges

(2019) Mohammad A. Khan et al.   DRUG DISCOVERY TODAY

Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1

(2019) Yuan Xu et al.   ONCOGENE

Distinct functions of AKT isoforms in breast cancer: a comprehensive review

(2019) Nico Hinz et al.   Cell Communication and Signaling

Cytotoxic macrocyclic diterpenoids from Jatropha multifida

(2018) Jun-Sheng Zhang et al.   BIOORGANIC CHEMISTRY

Triple negative breast cancer: Emerging therapeutic modalities and novel combination therapies

(2018) Alice Lee et al.   CANCER TREATMENT REVIEWS

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo

(2018) Lalita Guntuku et al.   ONCOGENE

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway

(2018) Shanshan Qi et al.   Acta Pharmaceutica Sinica B

Nanosoldiers: A promising strategy to combat triple negative breast cancer

(2018) Akshayya Pawar et al.   BIOMEDICINE & PHARMACOTHERAPY

Cytotoxic 8,9-seco-ent-kaurane diterpenoids from Croton kongensis

(2017) Shu-Qin Shi et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

(2017) Xiaoyun Tang et al.   Molecular Cancer

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt

(2017) Bill X. Huang et al.   Scientific Reports

Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure–Activity Relationships and Discovery of Promising MDR Reversal Agents

(2016) Jianyong Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression

(2014) Zhaoqing Wang et al.   DEVELOPMENTAL CELL

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach⊥†

(2010) Kuo-Hsiung Lee   JOURNAL OF NATURAL PRODUCTS

Ki67 in breast cancer: prognostic and predictive potential

(2010) Rinat Yerushalmi et al.   LANCET ONCOLOGY

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Ent-kaurane diterpenes and phenolic compounds from Croton kongensis (Euphorbiaceae)

(2009) Xiao-Dong Yang et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY