期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 110, 期 3, 页码 475-484出版社
OXFORD UNIV PRESS
DOI: 10.1002/JLB.3MA0321-736R
关键词
chemotaxis; Litsea cubeba; neutrophil; periodontitis
资金
- National Nature Science Foundation of China [81991504, 81974149]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201703]
- Beijing Baiqianwan Talents Project [2017A17]
- Beijing Peak Scheme Funding Support [DFL20181501]
- National High -level Talent Special Funding Support
This study found that the isoquinoline alkaloid Litcubanine A (LA) from the Traditional Chinese medicinal plant Litsea cubeba can effectively inhibit neutrophil chemotaxis, reduce tissue destruction in periodontitis, and decrease periodontitis bone loss by regulating neutrophil functions.
Neutrophil plays a critical role in the progression of periodontitis. In general, its chemotaxis and activation are benefit for the host defense of bacterial infection and inflammation. However, previous studies have reported that the hyperactive and reactive neutrophils appear to be one of the reasons for tissue destruction in periodontitis tissues. In this study, we investigated an isoquinoline alkaloid Litcubanine A (LA), which from the Traditional Chinese medicinal plant, Litsea cubeba. We found LA showed significant activity in inhibiting neutrophils chemotaxis in the zebrafish yolk sac microinjection model in vivo and in mouse neutrophils in vitro. Further investigation proved that LA could inhibit the expression levels of neutrophil respiratory burst-related and inflammation-related genes CYBB and NCF2, as well as inhibit the activation of MAPK signaling pathway. Moreover, using LA, we successfully achieved the effect of reducing periodontitis bone loss by regulating neutrophil chemotaxis and related functions in a mouse ligature-induced periodontitis model.
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