Non-Lyn Src Family Kinases Activate SIRPα–SHP-1 to Inhibit PI3K–Akt2 and Dampen Proinflammatory Macrophage Polarization

Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis

(2020) Junhua Xiao et al.   Molecular Medicine Reports

Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ

(2020) Koby Kidder et al.   JOURNAL OF IMMUNOLOGY

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shp2 Deficiency Impairs the Inflammatory Response AgainstHaemophilus influenzaeby Regulating Macrophage Polarization

(2016) Lifang Zhao et al.   JOURNAL OF INFECTIOUS DISEASES

Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells

(2016) Zhen Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α

(2013) Dihan Zhu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

‘Clustering’ SIRPα into the Plasma Membrane Lipid Microdomains Is Required for Activated Monocytes and Macrophages to Mediate Effective Cell Surface Interactions with CD47

(2013) Binh Ha et al.   PLoS One

Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state

(2013) Ke Zen et al.   Nature Communications

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

(2012) Francis J. Alenghat et al.   JOURNAL OF CELL SCIENCE

Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions

(2011) Z. Bian et al.   JOURNAL OF IMMUNOLOGY

The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system

(2011) Maria Lodeiro et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple roles of Lyn kinase in myeloid cell signaling and function

(2009) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions and molecular mechanisms of the CD47–SIRPα signalling pathway

(2009) Takashi Matozaki et al.   TRENDS IN CELL BIOLOGY