期刊
JOURNAL OF IMMUNOLOGY
卷 207, 期 2, 页码 523-533出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2100011
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资金
- National Institute of Allergy and Infectious Diseases of the National Institute of Health [U19 AI118626]
This study investigated the molecular profile of CD4 T cells in individuals with active tuberculosis, finding that HLA-DR can serve as a marker for recently expanded antigen-specific CD4 T cells.
Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell populations. To address this, we investigated the molecular profile of T cells present in individuals with active tuberculosis (ATB), where we expect Ag encounter and expansion of effector cells to occur at higher frequency in contrast to Mycobacterium tuberculosis-sensitized healthy IGRA(+) individuals. We found that the frequency of HLA-DR+ cells was increased in circulating CD4 T cells of ATB patients, and was dominantly expressed in M. tuberculosis Ag-specific CD4 T cells. We tested and confirmed that HLA-DR is a marker of recently divided CD4 T cells upon M. tuberculosis Ag exposure using an in vitro model examining the response of resting memory T cells from healthy IGRA(+) to Ags. Thus, HLA-DR marks a CD4 T cell population that can be directly detected ex vivo in human peripheral blood, whose frequency is increased during ATB disease and contains recently divided Ag-specific effector T cells. These findings will facilitate the monitoring and study of disease-specific effector T cell responses in the context of ATB and other infections.
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