Article
Immunology
Jingrong Chen, Feng Huang, Yuluan Hou, Xiaorong Lin, Rongzhen Liang, Xiaojiang Hu, Jun Zhao, Julie Wang, Nancy Olsen, Song Guo Zheng
Summary: This study demonstrated that EVs derived from in vitro TGF-beta-induced Treg cells (iTreg-EVs) efficiently prevented Th17/Treg cells imbalance in a murine model of autoimmune arthritis. By mediating Notch1 expression through miR-449a-5p, iTreg-EVs controlled inflammatory responses of recipient T cells, ameliorated the severity of arthritis, and may offer a potential cell-free strategy for preventing autoimmune arthritis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Tsung-Yen Huang, Masato Hirota, Daiki Sasaki, Rajkumar Singh Kalra, Hsiao-Chiao Chien, Miho Tamai, Shukla Sarkar, Yang Mi, Mio Miyagi, Yu Seto, Hiroki Ishikawa
Summary: Aerobic glycolysis, essential for effector T cell survival and proliferation, regulates Th17 differentiation through the negative regulation of phosphoenolpyruvate (PEP). PEP supplementation or inhibition of downstream glycolytic enzymes increases PEP levels and inhibits IL-17A expression. Mechanistically, PEP binds to JunB and inhibits DNA binding of the JunB/BATF/IRF4 complex, thereby modulating the Th17 transcriptional program. PEP administration inhibits Th17 generation and improves Th17-dependent autoimmune encephalomyelitis.
Article
Multidisciplinary Sciences
Ran Wang, Sean Campbell, Mohammed Amir, Sarah A. Mosure, Molly A. Bassette, Amber Eliason, Mark S. Sundrud, Theodore M. Kamenecka, Laura A. Solt
Summary: The study demonstrates the importance of ROR alpha in the pathogenicity of T(H)17 cells, and its deletion or inhibition with a small molecule antagonist can reduce disease development in EAE and colitis mouse models.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Sadek Amhaz, Batiste Boeda, Mouna Chouchene, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Celine Prunier, Laurence Levy
Summary: UBXN7 interacts with the RING domain of RNF111/RNF165 and TOPORS E3 ubiquitin ligases and regulates their activity by inhibiting E2 binding. The UAS thioredoxin-like domain of UBXN7 plays a key role in this regulation. This study reveals a novel mechanism of E3 ubiquitin ligase regulation through specific docking of a thioredoxin-like domain on RING domains.
Article
Cell Biology
Mary Flokis, Frank J. Lovicu
Summary: FGF-2 and TGF-beta can regulate LEC behavior, with FGF-2 promoting fiber differentiation and TGF-beta inducing EMT. When used together, central LECs undergo EMT while peripheral LECs favor fiber differentiation. This differential regulation is important in the development of lens pathology.
Article
Biology
A. Lorzadeh, C. Hammond, F. Wang, D. J. H. F. Knapp, J. Ch Wong, J. Y. A. Zhu, Q. Cao, A. Heravi-Moussavi, A. Carles, M. Wong, Z. Sharafian, J. Steif, M. Moksa, M. Bilenky, P. M. Lavoie, C. J. Eaves, M. Hirst
Summary: By generating comprehensive reference epigenomes of normal human cord blood, we have identified differences in chromatin modifications between different cell types. Particularly, the repressive H3K27me3 mark is retained in lymphoid cells but lost in monocytes and erythroblasts. Inhibition of polycomb group members also affects the fate decisions of neonatal hematopoietic progenitor cells.
Article
Immunology
Marc Kaethner, Kerstin Epping, Peter Bernthaler, Kilian Rudolf, Irena Thomann, Nadine Leitschuh, Monika Bergmann, Markus Spiliotis, Uriel Koziol, Klaus Brehm
Summary: This study reveals the crucial role of the TGF beta/BMP signaling pathway in anterior pole formation and protoscolex development of Echinococcus. Both host-derived TGF beta/BMP ligands and parasite-derived TGF beta homolog EmACT promote protoscolex development, while inhibition of TGF beta/BMP receptors hinders protoscolex differentiation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zi Zhen (Ginny) Liu, Aftab Taiyab, Judith A. West-Mays
Summary: The study demonstrated that MMP9 deficiency leads to differential regulation of proteins involved in actin polymerization and cell migration, thereby preventing TGF-beta-induced EMT in the lens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Junying Wang, Xingqi Zhao, Yisong Y. Wan
Summary: Balanced immunity is crucial for maintaining health and homeostasis. CD4(+) helper T (Th) cells play a central role in regulating immune tolerance and immune rejection. Regulatory T (Treg) and Th17 cells are important cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. Understanding the regulation of Treg and Th17 cell function by the TGF-beta superfamily and its signaling pathways is of great importance for both health and disease.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Microbiology
Wei He, Qianqian Mu, Lizhu Li, Xiaoqing Sun, Xianmin Fan, Fengjiao Yang, Meichen Liu, Biying Zhou
Summary: Excretory-secretory antigens (ESAs) of Cysticercus cellulosae can directly regulate the proliferation and differentiation of host T regulatory (Treg) cells, thus inhibiting host immune responses. Through proteomics analysis, this study found that C. cellulosae ESAs upregulate the TGF-beta signaling pathway and downregulate Th17 cell differentiation in piglet T cells. The study also discovered that the IL-2/STAT5 signaling pathway affects the downregulation of Th17 cell differentiation. This research provides insights into the molecular mechanism of C. cellulosae-mediated immune evasion.
Article
Immunology
Fanping Wang, Yonghui Yang, Zhixin Li, Yan Wang, Zhenchao Zhang, Wei Zhang, Yonghui Mu, Jingwen Yang, Lili Yu, Mingyong Wang
Summary: This study found that MBL regulates the balance between Th17 and Treg cells to resist Candida albicans infection, possibly through IL-6- and TGF-beta-mediated JAK/STAT and TGF-beta/SMAD signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ravinder K. Bahia, Xiaoguang Hao, Rozina Hassam, Orsolya Cseh, Danielle A. Bozek, H. Artee Luchman, Samuel Weiss
Summary: Histone deacetylases (HDACs) are important regulators in cancer stem cells (CSCs), and HDAC2 is identified as the crucial HDAC for maintaining the growth and self-renewal properties of brain tumor stem cells (BTSCs) in glioblastoma. It interacts with TGF-β pathway proteins, SMAD3 and SKI, to maintain the tumorigenic potential of BTSCs. Inhibition of HDAC2 activity and disrupting the HDAC2-SMAD3-SKI axis are potential therapeutic approaches for targeting BTSCs.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Pierre Marty, Brice Chatelain, Thomas Lihoreau, Marion Tissot, Zelie Dirand, Philippe Humbert, Clemence Senez, Eleonora Secomandi, Ciro Isidoro, Gwenael Rolin
Summary: Keloids are characterized by increased fibrous tissue deposition during abnormal wound healing. Halofuginone (HF) has been shown to inhibit fibrotic processes in keloid fibroblasts, offering a potential therapeutic approach for keloid prevention and management.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Chen Wang, Yuanming Xing, Jiao Zhang, Ming He, Jianjie Dong, Shanshan Chen, Haoyu Wu, Hsi-Yuan Huang, Chih-Hung Chou, Liang Bai, Fangzhou He, Jianqing She, Ailing Su, Youhua Wang, Patricia A. Thistlethwaite, Hsien-Da Huang, Jason X-J Yuan, Zu-Yi Yuan, John Y-J Shyy
Summary: The dysregulated BMP/TGF-beta signaling pathways play a crucial role in pulmonary arterial hypertension (PAH) and pulmonary hypertension (PH). MED1 and KLF4 collaboratively regulate BMPR2, ERG, and TGFBR2, highlighting the importance of their synergistic effect in maintaining pulmonary endothelial function. Dysregulation of MED1 contributes to impaired BMP/TGF-beta signaling and disease progression in PAH and PH.
CIRCULATION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Cong Hu, Yu Zhen, Zhanchuan Ma, Li Zhao, Hao Wu, Chang Shu, Bo Pang, Jinyu Yu, Ying Xu, Xin Zhang, Xiang-yang Wang, Huanfa Yi
Summary: Myeloid-derived suppressor cells (MDSCs) promote Th17 differentiation and aggravate SLE progression by producing arginase-1. However, the metabolic regulators remain unknown. In this study, it was found that MDSC derivative polyamines can promote Th17 differentiation via miR-542-5p in vitro.
Meeting Abstract
Gastroenterology & Hepatology
Henry H. Nguyen, Charlotte D'Mello, Stefan Urbanski, Tyson S. Le, Wagdi Almishri, Mark G. Swain
Editorial Material
Gastroenterology & Hepatology
Henry H. Nguyen, Paul L. Beck
Article
Gastroenterology & Hepatology
Henry H. Nguyen, Abdullah Khathlan, Marvin J. Fritzler, Mark G. Swain
BMC GASTROENTEROLOGY
(2018)
Article
Multidisciplinary Sciences
Henry H. Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J. Urbanski, Andrew L. Mason, Gary L. Norman, Marvin J. Fritzler, Mark G. Swain
Article
Gastroenterology & Hepatology
H. Nguyen, H. Wang, T. Le, W. Ho, K. A. Sharkey, M. G. Swain
NEUROGASTROENTEROLOGY AND MOTILITY
(2008)
Article
Gastroenterology & Hepatology
Abdel-Aziz Shaheen, Henry H. Nguyen, Stephen E. Congly, Gilaad G. Kaplan, Mark G. Swain
LIVER INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
June-Yong Lee, Jason A. Hall, Lina Kroehling, Lin Wu, Tariq Najar, Henry H. Nguyen, Woan-Yu Lin, Stephen T. Yeung, Hernandez Moura Silva, Dayi Li, Ashley Hine, P'ng Loke, David Hudesman, Jerome C. Martin, Ephraim Kenigsberg, Miriam Merad, Kamal M. Khanna, Dan R. Littman
Article
Multidisciplinary Sciences
Jhimmy Talbot, Paul Hahn, Lina Kroehling, Henry Nguyen, Dayi Li, Dan R. Littman
Article
Immunology
Wagdi Almishri, Liam A. Swain, Charlotte D'Mello, Tyson S. Le, Stefan J. Urbanski, Henry H. Nguyen
Summary: Increased expression of ADAM17 is observed in cholestatic liver diseases. Inhibition of ADAM17 activity improves liver injury and associated sickness behavior development, suggesting that ADAM17 inhibition may be a potential therapeutic approach for patients with cholestatic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Liam A. Swain, Anshula Ambasta, Erika Prando Munhoz, Onyebuchi Omodon, Stefan J. Urbanski, Henry H. Nguyen
Summary: This study analyzed liver enzyme levels in patients with COVID-19 and conducted detailed case analyses of two patients. The findings suggest that the Omicron variant of SARS-CoV-2 may result in severe liver injury. Liver biopsy showed the presence of SARS-CoV-2 in the liver with immune cell infiltration. Therefore, the Omicron variant should be considered in the differential diagnosis of severe acute liver injury.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Neurosciences
Henry H. Nguyen, Mark G. Swain
Summary: Symptoms of fatigue, social withdrawal and mood disturbances are common in patients with chronic liver disease. Limited treatment options exist for these symptoms, creating a medical need. This review examines potential mechanisms within the gut-liver-brain axis in chronic liver disease that contribute to the development of these symptoms, focusing on disruptions in immune response, microbiome, neural responses, and metabolite composition and their effects on the central nervous system.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Hassan Azhari, Alexandra D. Frolkis, Abdel Aziz Shaheen, Heidi Israelson, Jacqueline Pinto, Stephen E. Congly, Meredith A. Borman, Alexander A. Aspinall, Laura M. Stinton, Henry H. Nguyen, Mark G. Swain, Kelly W. Burak, Sam S. Lee, Matthew D. Sadler, Carla S. Coffin
Summary: Stopping nucleos(t)ide analogues (NUC) therapy is feasible in HBeAg negative chronic hepatitis B (CHB), but hepatic flares can still occur. Limited NUC therapy can be considered for eligible patients with close monitoring and follow-up in the first six months after stopping NUC therapy.
CANADIAN LIVER JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Henry H. Nguyen, Robert Bechara, William G. Paterson, Lawrence C. Hookey
ENDOSCOPY INTERNATIONAL OPEN
(2018)
Article
Gastroenterology & Hepatology
SM Kerfoot, C D'Mello, H Nguyen, MN Ajuebor, P Kubes, T Le, MG Swain
