C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer

(2021) Reiri Shimazaki et al.   CELLULAR ONCOLOGY

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity

(2020) Alexander H. Morrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features

(2019) Eva Karamitopoulou   BRITISH JOURNAL OF CANCER

Fetal lung C4BPA induces p100 processing in human placenta

(2019) Mayra Cruz Ithier et al.   Scientific Reports

Radiotherapy and CD40 activation separately augment immunity to checkpoint blockade in cancer

(2018) Andrew J Rech et al.   CANCER RESEARCH

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases

(2017) Michael Croft et al.   Nature Reviews Rheumatology

Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags

(2016) Kazuyuki Sogawa et al.   BRITISH JOURNAL OF CANCER

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend

(2016) David Ermert et al.   IMMUNOLOGY LETTERS

Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression

(2016) Y. Wang et al.   Cancer Discovery

CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

(2016) Katelyn T. Byrne et al.   Cell Reports

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

(2015) R. Winograd et al.   Cancer Immunology Research

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

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Agonistic CD40 Antibodies and Cancer Therapy

(2013) R. H. Vonderheide et al.   CLINICAL CANCER RESEARCH

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

(2012) Thomas Hofmeyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Optimized Peptide Vaccines Eliciting Extensive CD8 T-Cell Responses with Therapeutic Antitumor Effects

(2009) H.-I. Cho et al.   CANCER RESEARCH

Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation

(2009) Erica L Carpenter et al.   Journal of Translational Medicine

The role of CD40 and CD154/CD40L in dendritic cells

(2009) Daphne Y. Ma et al.   SEMINARS IN IMMUNOLOGY

Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines

(2008) C. L. Ahonen et al.   BLOOD

Immunosurveillance of pancreatic adenocarcinoma: Insights from genetically engineered mouse models of cancer

(2008) Carolyn E. Clark et al.   CANCER LETTERS

Effective induction of high-titer antibodies by viral vector vaccines

(2008) Simon J Draper et al.   NATURE MEDICINE